World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
72
Citations
17192
World Ranking
6359
National Ranking
2975

Research.com Recognitions

  • 2016 - ACM Gordon Bell Prize For 10M-Core Scalable Fully-Implicit Solver for Nonhydrostatic Atmospheric Dynamics
  • 2007 - Hellman Fellow

Overview

Li Gan is affiliated with Cornell University in the United States and has contributed extensively to research in medicine, biochemistry, genetics, molecular biology, and neuroscience. Their work intersects several subfields, notably molecular biology, neurology, physiology, immunology, and epidemiology.

The primary research topics Li Gan focuses on include neuroinflammation and neurodegeneration mechanisms, Alzheimer's disease research and treatments, interferon and immune responses, autophagy in disease and therapy, immune cells in cancer, single-cell and spatial transcriptomics, and neurological disease mechanisms and treatments.

Li Gan has published numerous papers in prominent scientific journals. Some recent examples include:

  • Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration, 2022, Cell
  • Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy, 2022, Nature Communications
  • Tau activation of microglial cGAS-IFN reduces MEF2C-mediated cognitive resilience, 2023, Nature Neuroscience
  • A CRISPRi/a platform in human iPSC-derived microglia uncovers regulators of disease states, 2022, Nature Neuroscience
  • Mechanisms of sex differences in Alzheimer's disease, 2024, Neuron

Frequent publication venues for Li Gan include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Molecular Neurodegeneration
  • Cell
  • Alzheimer's & Dementia
  • Zenodo (CERN European Organization for Nuclear Research)

Regular collaborators in Li Gan's research include Wenjie Luo, Man Ying Wong, Li Fan, Sue-Ann Mok, and Gillian Carling.

Li Gan has been recognized with awards such as the ACM Gordon Bell Prize in 2016 for work on a 10M-Core Scalable Fully-Implicit Solver for Nonhydrostatic Atmospheric Dynamics and held a Hellman Fellowship in 2007.

Best Publications

  • Acetylation of Tau Inhibits Its Degradation and Contributes to Tauopathy

    Sang Won Min;Seo Hyun Cho;Yungui Zhou;Sebastian Schroeder

  • SIRT1 Protects against Microglia-dependent Amyloid-β Toxicity through Inhibiting NF-κB Signaling

    Jennifer Chen;Yungui Zhou;Sarah Mueller-Steiner;Lin Feng Chen

  • Converging pathways in neurodegeneration, from genetics to mechanisms.

    Li Gan;Li Gan;Mark R. Cookson;Leonard Petrucelli;Albert R. La Spada

  • Antiamyloidogenic and Neuroprotective Functions of Cathepsin B: Implications for Alzheimer's Disease

    Sarah Mueller-Steiner;Yungui Zhou;Hideaki Arai;Hideaki Arai;Erik D. Roberson

  • Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits

    Sang-Won Min;Xu Chen;Tara E Tracy;Yaqiao Li

  • Phospholipase A2 reduction ameliorates cognitive deficits in a mouse model of Alzheimer's disease

    Rene O. Sanchez-Mejia;John W. Newman;Sandy Toh;Gui Qiu Yu

  • Contribution of the Kv3.1 potassium channel to high‐frequency firing in mouse auditory neurones

    Lu-Yang Wang;Li Gan;Ian D. Forsythe;Leonard K. Kaczmarek

  • New non-viral method for gene transfer into primary cells.

    Oliver Gresch;Felix B Engel;Dobrila Nesic;Thi Thai Tran

  • Scalable Production of iPSC-Derived Human Neurons to Identify Tau-Lowering Compounds by High-Content Screening

    Chao Wang;Michael E. Ward;Michael E. Ward;Robert Chen;Kai Liu

  • Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury.

    Lauren Herl Martens;Jiasheng Zhang;Jiasheng Zhang;Sami J. Barmada;Sami J. Barmada;Ping Zhou

  • Oxidative damage and the Nrf2-ARE pathway in neurodegenerative diseases.

    Li Gan;Jeffrey A. Johnson

  • Transcription Factor-Mediated Differentiation of Human iPSCs into Neurons.

    Michael S. Fernandopulle;Ryan Prestil;Christopher Grunseich;Chao Wang

  • CX3CR1 Protein Signaling Modulates Microglial Activation and Protects against Plaque-independent Cognitive Deficits in a Mouse Model of Alzheimer Disease

    Seo Hyun Cho;Binggui Sun;Binggui Sun;Yungui Zhou;Tiina M. Kauppinen

  • SIRT1 Deficiency in Microglia Contributes to Cognitive Decline in Aging and Neurodegeneration via Epigenetic Regulation of IL-1β

    Seo-Hyun Cho;Jason A. Chen;Faten Sayed;Michael E. Ward

  • Localization of the Slack potassium channel in the rat central nervous system.

    Arin Bhattacharjee;Li Gan;Leonard K. Kaczmarek

  • Cystatin C-cathepsin B axis regulates amyloid beta levels and associated neuronal deficits in an animal model of Alzheimer's disease.

    Binggui Sun;Yungui Zhou;Brian Halabisky;Iris Lo

  • Paths of Convergence: Sirtuins in Aging and Neurodegeneration

    Li Gan;Lennart Mucke

  • Imbalance between GABAergic and Glutamatergic Transmission Impairs Adult Neurogenesis in an Animal Model of Alzheimer's Disease.

    Binggui Sun;Brian Halabisky;Yungui Zhou;Jorge J. Palop

  • Progranulin protects against amyloid β deposition and toxicity in Alzheimer's disease mouse models

    S Sakura Minami;Sang-Won Min;Grietje Krabbe;Chao Wang

  • Erratum to Acetylation of tau inhibits its degradation and contributes to tauopathy

    Sang Won Min;Seo Hyun Cho;Yungui Zhou;Sebastian Schroeder

Frequent Co-Authors

Lennart Mucke
Lennart Mucke University of California, San Francisco
William W. Seeley
William W. Seeley University of California, San Francisco
Lea T. Grinberg
Lea T. Grinberg University of California, San Francisco
Bruce L. Miller
Bruce L. Miller University of California, San Francisco
Jason E. Gestwicki
Jason E. Gestwicki University of California, San Francisco
Giovanni Coppola
Giovanni Coppola University of California, Los Angeles
Leonard K. Kaczmarek
Leonard K. Kaczmarek Yale University
Eric J. Huang
Eric J. Huang University of California, San Francisco
Robert V. Farese
Robert V. Farese Harvard University
Nevan J. Krogan
Nevan J. Krogan University of California, San Francisco

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