World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
90
Citations
42937
World Ranking
2389
National Ranking
1270

Research.com Recognitions

  • 2012 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Jason E. Gestwicki is affiliated with the University of California, San Francisco in the United States. Their research focuses predominantly within the field of Biochemistry, Genetics, and Molecular Biology, with a substantial number of publications totaling 182. Within this broad field, their work also spans several subfields including Molecular Biology, Cell Biology, Physiology, Neurology, and Materials Chemistry.

Themainscientific topics covered in Gestwicki's research encompass multiple areas, notably:

  • Heat shock proteins research
  • Protein Structure and Dynamics
  • Endoplasmic Reticulum Stress and Disease
  • Alzheimer's disease research and treatments
  • Ubiquitin and proteasome pathways
  • Enzyme Structure and Function
  • Computational Drug Discovery Methods

Their publication record includes frequent contributions to several venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Zenodo (CERN European Organization for Nuclear Research)
  • Nature Communications
  • Cell chemical biology
  • Cell Stress and Chaperones

Recent notable papers authored or co-authored by Gestwicki include:

  • Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy, 2022, Nature Communications
  • Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice, 2021, Nature Communications
  • Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking, 2021, Science Advances
  • Adhesion-mediated mechanosignaling forces mitohormesis, 2021, Cell Metabolism
  • Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 macrodomain of SARS-CoV-2, 2023, Proceedings of the National Academy of Sciences

Frequent collaborators in their research include:

  • Hao Shao
  • Taiasean Wu
  • Aye C. Thwin
  • Emma C. Carroll
  • Cory M. Nadel

Throughout their career, Gestwicki has been recognized as a Fellow of the American Association for the Advancement of Science (AAAS) in 2012.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy

    Daniel J. Klionsky;Fabio C. Abdalla;Hagai Abeliovich;Robert T. Abraham

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Potential therapeutic applications of autophagy.

    David C. Rubinsztein;Jason E. Gestwicki;Leon O. Murphy;Daniel J. Klionsky

  • Synthetic Multivalent Ligands as Probes of Signal Transduction

    Laura L. Kiessling;Jason E. Gestwicki;Jason E. Gestwicki;Laura E. Strong

  • Influencing Receptor−Ligand Binding Mechanisms with Multivalent Ligand Architecture

    Jason E. Gestwicki;Christopher W. Cairo;Laura E. Strong;Karolyn A. Oetjen

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Synthetic multivalent ligands in the exploration of cell-surface interactions.

    Laura L. Kiessling;Jason E Gestwicki;Laura E Strong

  • Solution conformation of wild-type E. coli Hsp70 (DnaK) chaperone complexed with ADP and substrate.

    Eric B. Bertelsen;Lyra Chang;Jason E. Gestwicki;Erik R. P. Zuiderweg

  • Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits

    Sang-Won Min;Xu Chen;Tara E Tracy;Yaqiao Li

  • Heat Shock Proteins 70 and 90 Inhibit Early Stages of Amyloid β-(1–42) Aggregation in Vitro

    Christopher G. Evans;Susanne Wisén;Jason E. Gestwicki

  • Control of Multivalent Interactions by Binding Epitope Density

    Christopher W Cairo;Jason E Gestwicki;Motomu Kanai;Laura L Kiessling

  • Heat shock protein 70 (hsp70) as an emerging drug target.

    Christopher G. Evans;Lyra Chang;Jason E. Gestwicki

  • Structure-activity relationships of amyloid beta-aggregation inhibitors based on curcumin: influence of linker length and flexibility.

    Ashley A. Reinke;Jason E. Gestwicki

  • A Field of Myocardial-Endocardial NFAT Signaling Underlies Heart Valve Morphogenesis

    Ching Pin Chang;Joel R. Neilson;J. Henri Bayle;Jason E. Gestwicki

  • Inter-receptor communication through arrays of bacterial chemoreceptors

    Jason E. Gestwicki;Laura L. Kiessling

  • Methylthioninium chloride (methylene blue) induces autophagy and attenuates tauopathy in vitro and in vivo

    Erin E. Congdon;Jessica W. Wu;Natura Myeku;Yvette H. Figueroa

  • Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Defining Hsp70 Subnetworks in Dengue Virus Replication Reveals Key Vulnerability in Flavivirus Infection

    Shuhei Taguwa;Kevin Maringer;Kevin Maringer;Xiaokai Li;Dabeiba Bernal-Rubio

  • Features of protein-protein interactions that translate into potent inhibitors: topology, surface area and affinity

    Matthew C. Smith;Jason E. Gestwicki

  • Chemical Manipulation of Hsp70 ATPase Activity Regulates Tau Stability

    Umesh K. Jinwal;Yoshinari Miyata;John Koren;Jeffrey R. Jones

Frequent Co-Authors

Chad A. Dickey
Chad A. Dickey University of South Florida
Erik R. P. Zuiderweg
Erik R. P. Zuiderweg University of Michigan–Ann Arbor
Gerald R. Crabtree
Gerald R. Crabtree Stanford University
Li Gan
Li Gan Cornell University
Heather A. Carlson
Heather A. Carlson University of Michigan–Ann Arbor
Andrew P. Lieberman
Andrew P. Lieberman University of Michigan–Ann Arbor
Jeffrey L. Brodsky
Jeffrey L. Brodsky University of Pittsburgh
Martin Kampmann
Martin Kampmann University of California, San Francisco
Ana Maria Cuervo
Ana Maria Cuervo Albert Einstein College of Medicine

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Exploring Biology and Biochemistry often opens doors to dynamic careers in healthcare, management, and nutrition. Today, online degrees make it easier than ever to diversify or advance your career in related fields. If you are interested in healthcare leadership, there are fastest online master's in healthcare management options designed to accelerate your studies and get you into a leadership role quickly.

Psychology and mental health also have strong ties to biochemistry and biology. Fast-track your entry into this growing field with a fastest pmhnp program and help address mental health needs in various populations.

If nutrition interests you, especially from a biochemical or health sciences perspective, you’ll find several fastest nutrition degree online programs that can launch your career in wellness or public health nutrition.

For those looking at the business side of healthcare, consider an affordable online mba healthcare management to sharpen your administrative skills and take on strategic roles within health organizations.

Best Scientists Citing Jason E. Gestwicki

Trending Scientists

Recently Published Articles