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Gerald R. Crabtree

Gerald R. Crabtree

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Molecular Biology
USA
2026

D-Index & Metrics

Molecular Biology

D-Index
149
Citations
84481
World Ranking
87
National Ranking
55

Research.com Recognitions

  • 2026 - Research.com Molecular Biology in United States Leader Award
  • 2025 - Research.com Molecular Biology in United States Leader Award
  • 2023 - Research.com Molecular Biology in United States Leader Award
  • 1998 - Fellow of the American Academy of Microbiology Immunology
  • 1997 - Member of the National Academy of Sciences

Overview

Gerald R. Crabtree is affiliated with Stanford University in the United States and has contributed extensively to research within biochemistry, genetics, and molecular biology, with a specific emphasis on molecular biology. Their work spans several subfields, including immunology, pathology and forensic medicine, cellular and molecular neuroscience, and genetics.

The scientist's research covers key topics such as chromatin remodeling and cancer, protein degradation and inhibitors, cancer mechanisms and therapy, ubiquitin and proteasome pathways, genomics and chromatin dynamics, neuroscience and neuropharmacology research, and genetics and neurodevelopmental disorders.

Gerald R. Crabtree has published numerous papers, including the following recent works:

  • Rewiring cancer drivers to activate apoptosis (2023), published in Nature
  • mSWI/SNF promotes Polycomb repression both directly and through genome-wide redistribution (2021), published in Nature Structural & Molecular Biology
  • Context-specific functions of chromatin remodellers in development and disease (2023), published in Nature Reviews Genetics
  • LSH mediates gene repression through macroH2A deposition (2020), published in Nature Communications
  • Relocalizing transcriptional kinases to activate apoptosis (2024), published in Science

The scientist collaborates frequently with several coauthors, including Sai Gourisankar, A. Krokhotin, Wendy Wenderski, Tinghu Zhang, and Nathanael S. Gray.

Gerald R. Crabtree has published regularly in venues such as BioRxiv (Cold Spring Harbor Laboratory), Nature, Nature Communications, eLife, and Nature Immunology.

Among recognitions earned by this researcher are the Fellow of the American Academy of Microbiology award in 1998 for work related to immunology, and they were named a Member of the National Academy of Sciences in 1997.

Best Publications

  • The mechanism of action of cyclosporin A and FK506

    Stuart L Schreiber;Gerald R Crabtree

  • Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation

    Neil A. Clipstone;Gerald R. Crabtree

  • NFAT Signaling: Choreographing the Social Lives of Cells

    Gerald R Crabtree;Eric N Olson

  • Contingent genetic regulatory events in T lymphocyte activation

    Gerald R. Crabtree

  • Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases.

    Jongkyeong Chung;Calvin J. Kuo;Gerald R. Crabtree;John Blenis

  • Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A.

    W. Michael Flanagan;Blaise Corthésy;Richard J. Bram;Gerald R. Crabtree

  • Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy

    Cigall Kadoch;Diana C Hargreaves;Courtney Hodges;Laura Elias

  • Chromatin remodelling during development

    Lena Ho;Gerald R. Crabtree

  • Identification of a putative regulator of early T cell activation genes

    Jeng-Pyng Shaw;P. J. Utz;D. B. Durand;J. J. Toole

  • Interleukin-2-mediated elimination of the p27Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin.

    Jamison Nourse;Eduardo Firpo;W. Michael Flanagan;Steve Coats

  • MicroRNA-mediated conversion of human fibroblasts to neurons

    Andrew S. Yoo;Alfred X. Sun;Li Li;Aleksandr Shcheglovitov

  • Controlling signal transduction with synthetic ligands

    David M. Spencer;Thomas J. Wandless;Stuart L. Schreiber;Gerald R. Crabtree

  • Molecular cloning and expression of cDNAs for the human interleukin-2 receptor

    Warren J. Leonard;Joel M. Depper;Gerald R. Crabtree;Stuart Rudikoff

  • Nuclear Export of NF-ATc Enhanced by Glycogen Synthase Kinase-3

    Chan R. Beals;Colleen M. Sheridan;Christoph W. Turck;Phyllis Gardner

  • Purification and biochemical heterogeneity of the mammalian SWI-SNF complex.

    Weidong Wang;Jacques Côté;Yutong Xue;Sharleen Zhou

  • Diversity and specialization of mammalian SWI/SNF complexes.

    Weidong Wang;Yutong Xue;Sharleen Zhou;Ann Kuo

  • ATP-dependent chromatin remodeling: genetics, genomics and mechanisms

    Diana C Hargreaves;Gerald R Crabtree

  • Generic Signals and Specific Outcomes: Signaling through Ca2+, Calcineurin, and NF-AT

    Gerald R Crabtree

  • A Brg1 null mutation in the mouse reveals functional differences among mammalian SWI/SNF complexes.

    Scott Bultman;Tom Gebuhr;Della Yee;Christian La Mantia

  • The mechanism of action of cyclosporin A and FK506.

    Steffan Ho;Neil Clipstone;Luika Timmermann;Jeffrey Northrop

Frequent Co-Authors

Thomas J. Wandless
Thomas J. Wandless Stanford University
Stuart L. Schreiber
Stuart L. Schreiber Harvard University
Jason E. Gestwicki
Jason E. Gestwicki University of California, San Francisco
Keji Zhao
Keji Zhao National Institutes of Health
David M. Spencer
David M. Spencer Baylor College of Medicine
Kendall A. Smith
Kendall A. Smith Cornell University
Calvin J. Kuo
Calvin J. Kuo Stanford University
Paul A. Khavari
Paul A. Khavari Stanford University
Weidong Wang
Weidong Wang National Institutes of Health
Uta Francke
Uta Francke Stanford University

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