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D-Index & Metrics

Biology and Biochemistry

D-Index
62
Citations
14091
World Ranking
10773
National Ranking
775

Overview

Edgar Serfling is affiliated with the University of Würzburg in Germany and has contributed to research across several interrelated disciplines including Biochemistry, Genetics and Molecular Biology, Immunology and Microbiology, and Medicine. Their work spans a variety of subfields such as Immunology, Molecular Biology, Dermatology, Cell Biology, and Surgery.

The main thematic focus of Serfling's research involves signaling pathways in disease and immune cell function and interaction. Additional topics covered include Aldose Reductase and Taurine, Ubiquitin and proteasome pathways, Macrophage Migration Inhibitory Factor, IL-33, ST2, and ILC pathways, and Eosinophilic Esophagitis.

Among the recent papers authored or co-authored by Serfling are:

  • Lack of NFATc1 SUMOylation prevents autoimmunity and alloreactivity, 2020, The Journal of Experimental Medicine
  • ATP/IL-33-triggered hyperactivation of mast cells results in an amplified production of pro-inflammatory cytokines and eicosanoids, 2021, Immunology
  • Biallelic NFATC1 mutations cause an inborn error of immunity with impaired CD8+ T-cell function and perturbed glycolysis, 2023, Blood
  • NFATc1 Fosters Allergic Contact Dermatitis Responses by Enhancing the Induction of IL-17-Producing CD8 Cells, 2024, Journal of Investigative Dermatology
  • NFATc1 deficiency in B cells ameliorates atopic dermatitis, 2025, Scientific Reports

Frequent collaborators in their research include Stefan Klein-Heßling, Khalid Muhammad, Matthias Klein, Tobias Bopp, and Muhammad Azeem. The studies conducted with these co-authors have contributed to the broader understanding of immune system regulation and dermatological immune responses.

Serfling's work has been published in several peer-reviewed venues illustrating diverse research interests, including The Journal of Experimental Medicine, Immunology, Journal of Investigative Dermatology, Blood, and Scientific Reports.

Best Publications

  • Epigenetic Control of the foxp3 Locus in Regulatory T Cells

    Stefan Floess;Jennifer Freyer;Christiane Siewert;Udo Baron

  • Autoamplification of NFATc1 expression determines its essential role in bone homeostasis.

    Masataka Asagiri;Kojiro Sato;Takako Usami;Sae Ochi

  • Cyclic adenosine monophosphate is a key component of regulatory T cell–mediated suppression

    Tobias Bopp;Christian Becker;Matthias Klein;Stefan Klein-Heßling

  • The architecture of the interleukin-2 promoter: a reflection of T lymphocyte activation.

    Edgar Serfling;Andris Avots;Manfred Neumann

  • The role of NF-AT transcription factors in T cell activation and differentiation

    Edgar Serfling;Friederike Berberich-Siebelt;Sergei Chuvpilo;Eriks Jankevics

  • Store-Operated Ca2+ Entry Controls Clonal Expansion of T Cells through Metabolic Reprogramming

    Martin Vaeth;Mate Maus;Stefan Klein-Hessling;Elizaveta Freinkman

  • Multiple closely-linked NFAT/octamer and HMG I(Y) binding sites are part of the interleukin-4 promoter.

    S Chuvpilo;C Schomberg;R Gerwig;A Heinfling

  • RelA/p65 is a molecular target for the immunosuppressive action of protein kinase A.

    M Neumann;T Grieshammer;S Chuvpilo;B Kneitz

  • Differential expression of Rel/NF-κB and octamer factors is a hallmark of the generation and maturation of dendritic cells

    M. Neumann;H.-W. Fries;C. Scheicher;P. Keikavoussi

  • Induction of NFATc2 Expression by Interleukin 6 Promotes T Helper Type 2 Differentiation

    Sean Diehl;Chi Wing Chow;Linda Weiss;Alois Palmetshofer

  • Autoregulation of NFATc1/A Expression Facilitates Effector T Cells to Escape from Rapid Apoptosis

    Sergei Chuvpilo;Eriks Jankevics;Dimitri Tyrsin;Askar Akimzhanov

  • Alternative polyadenylation events contribute to the induction of NF-ATc in effector T cells.

    Sergei Chuvpilo;Michael Zimmer;Andreas Kerstan;Judith Glöckner

  • Transforming growth factor beta and cyclosporin A inhibit the inducible activity of the interleukin-2 gene in T cells through a noncanonical octamer-binding site.

    Thomas Brabletz;Isolde Pfeuffer;Elke Schorr;Friederike Siebelt

  • IL-9 and IL-13 production by activated mast cells is strongly enhanced in the presence of lipopolysaccharide: NF-kappa B is decisively involved in the expression of IL-9.

    Michael Stassen;Christian Müller;Martina Arnold;Lothar Hültner

  • NFATc1 controls the cytotoxicity of CD8+ T cells

    Stefan Klein-Hessling;Khalid Muhammad;Matthias Klein;Tobias Pusch

  • RelB Forms Transcriptionally Inactive Complexes with RelA/p65 *

    Ralf B. Marienfeld;Michael J. May;Ingolf Berberich;Edgar Serfling

  • NFATc2 and NFATc3 transcription factors play a crucial role in suppression of CD4+ T lymphocytes by CD4+ CD25+ regulatory T cells.

    Tobias Bopp;Alois Palmetshofer;Edgar Serfling;Valeska Heib

  • CBP/p300 Integrates Raf/Rac-Signaling Pathways in the Transcriptional Induction of NF-ATc during T Cell Activation

    Andris Avots;Mathias Buttmann;Sergei Chuvpilo;Cornelia Escher

  • Current Developments in the Immunology of Psoriasis.

    Franziska Grän;Andreas Kerstan;Edgar Serfling;Matthias Goebeler

  • Follicular regulatory T cells control humoral autoimmunity via NFAT2-regulated CXCR5 expression

    Martin Vaeth;Gerd Müller;Dennis Stauss;Lena Dietz

Frequent Co-Authors

Tobias Bopp
Tobias Bopp Johannes Gutenberg University of Mainz
Edgar Schmitt
Edgar Schmitt Johannes Gutenberg University of Mainz
Hansjörg Schild
Hansjörg Schild Johannes Gutenberg University of Mainz
Matthias Goebeler
Matthias Goebeler University of Würzburg
Albert Sickmann
Albert Sickmann Leibniz Institute for Neurobiology
Andreas Rosenwald
Andreas Rosenwald University of Würzburg
Thomas Wirth
Thomas Wirth University of Ulm
Min Li-Weber
Min Li-Weber German Cancer Research Center
Helmut Jonuleit
Helmut Jonuleit Johannes Gutenberg University of Mainz
Ulf R. Rapp
Ulf R. Rapp Max Planck Society

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