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Biology and Biochemistry

D-Index
49
Citations
19618
World Ranking
17822
National Ranking
1230

Overview

Helmut Jonuleit is affiliated with Johannes Gutenberg University of Mainz in Germany. Their research primarily spans the fields of Immunology and Microbiology, Biochemistry, Genetics and Molecular Biology, and Medicine. Within these broader areas, their work focuses on Immunology, Molecular Biology, and Oncology.

The main topics explored in Jonuleit's research include Immunotherapy and Immune Responses, Melanoma and MAPK Pathways, Immune Cell Function and Interaction, T-cell and B-cell Immunology, Protein Kinase Regulation and GTPase Signaling, Protein Tyrosine Phosphatases, and Cancer Cells and Metastasis.

Jonuleit has collaborated frequently with several coauthors, including:

  • Andrea Tuettenberg
  • Krishnaraj Rajalingam
  • K. Satoh
  • Yoichi Kobayashi
  • Kaori Fujimaki

Their publications have appeared repeatedly in journals such as:

  • Cancer Gene Therapy
  • International Immunology
  • Cell Death and Disease
  • International Journal of Molecular Sciences
  • Cancer Research

Significant papers authored or co-authored by Jonuleit include:

  • Novel anti-GARP antibody DS-1055a augments anti-tumor immunity by depleting highly suppressive GARP+ regulatory T cells, 2021, International Immunology
  • ERK5 modulates IL-6 secretion and contributes to tumor-induced immune suppression, 2021, Cell Death and Disease
  • ERK3/MAPK6 is required for KRAS-mediated NSCLC tumorigenesis, 2020, Cancer Gene Therapy
  • In-Depth Immune-Oncology Studies of the Tumor Microenvironment in a Humanized Melanoma Mouse Model, 2021, International Journal of Molecular Sciences
  • Abstract 1847: Anti-GARP antibody DS-1055a augments antitumor immunity by depleting highly suppressive GARP+ regulatory T cells, 2021, Cancer Research

Best Publications

  • Induction of Interleukin 10–Producing, Nonproliferating Cd4+ T Cells with Regulatory Properties by Repetitive Stimulation with Allogeneic Immature Human Dendritic Cells

    Helmut Jonuleit;Edgar Schmitt;Gerold Schuler;Jürgen Knop

  • Vaccination with Mage-3a1 Peptide–Pulsed Mature, Monocyte-Derived Dendritic Cells Expands Specific Cytotoxic T Cells and Induces Regression of Some Metastases in Advanced Stage IV Melanoma

    Beatrice Thurner;Ina Haendle;Claudia Röder;Detlef Dieckmann

  • Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral blood

    Helmut Jonuleit;Edgar Schmitt;Michael Stassen;Andrea Tuettenberg

  • Pro‐inflammatory cytokines and prostaglandins induce maturation of potent immunostimulatory dendritic cells under fetal calf serum‐free conditions

    Helmut Jonuleit;Ulrich Kühn;Gabriele Müller;Kerstin Steinbrink

  • Cyclic adenosine monophosphate is a key component of regulatory T cell–mediated suppression

    Tobias Bopp;Christian Becker;Matthias Klein;Stefan Klein-Heßling

  • Infectious Tolerance: Human CD25+ Regulatory T Cells Convey Suppressor Activity to Conventional CD4+ T Helper Cells

    Helmut Jonuleit;Edgar Schmitt;Hacer Kakirman;Michael Stassen

  • Dendritic cells as a tool to induce anergic and regulatory T cells.

    Helmut Jonuleit;Edgar Schmitt;Kerstin Steinbrink;Alexander H Enk

  • Dacarbazine (DTIC) versus vaccination with autologous peptide-pulsed dendritic cells (DC) in first-line treatment of patients with metastatic melanoma: a randomized phase III trial of the DC study group of the DeCOG

    D. Schadendorf;S. Ugurel;B. Schuler-Thurner;F.O. Nestle

  • The Regulatory T Cell Family: Distinct Subsets and their Interrelations

    Helmut Jonuleit;Edgar Schmitt

  • Immature, but not inactive: the tolerogenic function of immature dendritic cells

    Karsten Mahnke;Edgar Schmitt;Laura Bonifaz;Alexander H Enk

  • Dendritic cells as mediators of tumor‐induced tolerance in metastatic melanoma

    Alexander H. Enk;Helmut Jonuleit;Joachim Saloga;Jürgen Knop

  • A comparison of two types of dendritic cell as adjuvants for the induction of melanoma-specific T-cell responses in humans following intranodal injection.

    Helmut Jonuleit;Andrea Giesecke‐Tuettenberg;Thomas Tüting;Beatrice Thurner‐Schuler

  • Production of functional IL-18 by different subtypes of murine and human dendritic cells (DC): DC- derived IL-18 enhances IL-12-dependent Th1 development

    Sabine Stoll;Helmut Jonuleit;Edgar Schmitt;Gabriele Müller

  • Mage-3 and influenza-matrix peptide-specific cytotoxic T cells are inducible in terminal stage HLA-A2.1+ melanoma patients by mature monocyte-derived dendritic cells.

    B Schuler-Thurner;D Dieckmann;P Keikavoussi;A Bender

  • Costimulatory Molecules on Immunogenic Versus Tolerogenic Human Dendritic Cells

    Mario Hubo;Bettina Trinschek;Fanny Kryczanowsky;Andrea Tuettenberg

  • Human CD4+CD25+ regulatory T cells: proteome analysis identifies galectin-10 as a novel marker essential for their anergy and suppressive function.

    Jan Kubach;Petra Lutter;Tobias Bopp;Sabine Stoll

  • Human CD25+ regulatory T cells: two subsets defined by the integrins α4β7 or α4β1 confer distinct suppressive properties upon CD4+ T helper cells

    Michael Stassen;Sabine Fondel;Tobias Bopp;Christoph Richter

  • Different efficiency of heat shock proteins (HSP) to activate human monocytes and dendritic cells: superiority of HSP60.

    Karen Bethke;Frank Staib;Martin Distler;Ute Schmitt

  • Induction of IL-15 messenger RNA and protein in human blood-derived dendritic cells: a role for IL-15 in attraction of T cells.

    H Jonuleit;K Wiedemann;G Müller;J Degwert

  • ICOS and CD28 reversely regulate IL-10 on re-activation of human effector T cells with mature dendritic cells

    Esther J. Witsch;Matthias Peiser;Andreas Hutloff;Kerstin Büchner

Frequent Co-Authors

Alexander Enk
Alexander Enk Heidelberg University
Edgar Schmitt
Edgar Schmitt Johannes Gutenberg University of Mainz
Jürgen Knop
Jürgen Knop Johannes Gutenberg University of Mainz
Tobias Bopp
Tobias Bopp Johannes Gutenberg University of Mainz
John Wijdenes
John Wijdenes Grenoble Alpes University
Stephan Grabbe
Stephan Grabbe Johannes Gutenberg University of Mainz
Ari Waisman
Ari Waisman Johannes Gutenberg University of Mainz
Hansjörg Schild
Hansjörg Schild Johannes Gutenberg University of Mainz
Andreas Daiber
Andreas Daiber Johannes Gutenberg University of Mainz
Frauke Zipp
Frauke Zipp Johannes Gutenberg University of Mainz

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