World's Best Scientists 2026 revealed!

D-Index & Metrics

Microbiology

D-Index
80
Citations
32525
World Ranking
1135
National Ranking
69

Medicine

D-Index
87
Citations
40378
World Ranking
13419
National Ranking
718

Overview

Alexander Enk is affiliated with Heidelberg University in Germany and specializes in medical research, with a primary focus on oncology and dermatology. Their scholarly output includes 246 publications in medicine, with significant contributions to subfields such as oncology, dermatology, epidemiology, immunology, and genetics.

The scientist's research covers multiple topics related to skin diseases and cancer, including:

  • Cutaneous Melanoma Detection and Management
  • Autoimmune Bullous Skin Diseases
  • Nonmelanoma Skin Cancer Studies
  • Cutaneous lymphoproliferative disorders research
  • AI in cancer detection
  • Psoriasis: Treatment and Pathogenesis
  • Dermatology and Skin Diseases

Frequent publishing venues for their work include:

  • JDDG Journal der Deutschen Dermatologischen Gesellschaft (25 publications)
  • European Journal of Cancer (14 publications)
  • Journal of Investigative Dermatology (13 publications)
  • Der Hautarzt (12 publications)
  • The Journal of Dermatology (9 publications)

Alexander Enk's recent papers illustrate research interest in diagnostic performance, immunotherapy, and melanoma. Notable publications are:

  • "Man against machine reloaded: performance of a market-approved convolutional neural network in classifying a broad spectrum of skin lesions in comparison with 96 dermatologists working under less artificial conditions," 2020, Annals of Oncology
  • "Assessment of Diagnostic Performance of Dermatologists Cooperating With a Convolutional Neural Network in a Prospective Clinical Study," 2023, JAMA Dermatology
  • "Programmed cell death protein 1 inhibitors in advanced cutaneous squamous cell carcinoma: real-world data of a retrospective, multicenter study," 2020, European Journal of Cancer
  • "Soluble immune checkpoints and T-cell subsets in blood as biomarkers for resistance to immunotherapy in melanoma patients," 2021, OncoImmunology
  • "Male fertility during and after immune checkpoint inhibitor therapy: A cross-sectional pilot study," 2021, European Journal of Cancer

Frequent collaborators include Ferdinand Toberer, Holger A. Haenssle, Julia K. Winkler, Christine Fink, and Ines Bertlich, contributing to numerous joint publications.

Best Publications

  • Induction of Interleukin 10–Producing, Nonproliferating Cd4+ T Cells with Regulatory Properties by Repetitive Stimulation with Allogeneic Immature Human Dendritic Cells

    Helmut Jonuleit;Edgar Schmitt;Gerold Schuler;Jürgen Knop

  • Vaccination with Mage-3a1 Peptide–Pulsed Mature, Monocyte-Derived Dendritic Cells Expands Specific Cytotoxic T Cells and Induces Regression of Some Metastases in Advanced Stage IV Melanoma

    Beatrice Thurner;Ina Haendle;Claudia Röder;Detlef Dieckmann

  • Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral blood

    Helmut Jonuleit;Edgar Schmitt;Michael Stassen;Andrea Tuettenberg

  • Induction of tolerance by IL-10-treated dendritic cells.

    K Steinbrink;M Wölfl;H Jonuleit;J Knop

  • Man against machine: diagnostic performance of a deep learning convolutional neural network for dermoscopic melanoma recognition in comparison to 58 dermatologists.

    H.A. Haenssle;C. Fink;R. Schneiderbauer;F. Toberer

  • Pro‐inflammatory cytokines and prostaglandins induce maturation of potent immunostimulatory dendritic cells under fetal calf serum‐free conditions

    Helmut Jonuleit;Ulrich Kühn;Gabriele Müller;Kerstin Steinbrink

  • Interleukin-12 is produced by dendritic cells and mediates T helper 1 development as well as interferon-gamma production by T helper 1 cells.

    Christine Heufler;Franz Koch;Ursula Stanzl;Gerda Topar

  • Infectious Tolerance: Human CD25+ Regulatory T Cells Convey Suppressor Activity to Conventional CD4+ T Helper Cells

    Helmut Jonuleit;Edgar Schmitt;Hacer Kakirman;Michael Stassen

  • Early molecular events in the induction phase of contact sensitivity

    Alexander H. Enk;Stephen I. Katz

  • Inhibition of Langerhans cell antigen-presenting function by IL-10. A role for IL-10 in induction of tolerance.

    A H Enk;V L Angeloni;M C Udey;S I Katz

  • Interleukin-10-treated human dendritic cells induce a melanoma-antigen-specific anergy in CD8(+) T cells resulting in a failure to lyse tumor cells.

    Kerstin Steinbrink;Helmut Jonuleit;Helmut Jonuleit;Gabriele Müller;Gabriele Müller;Gerold Schuler;Gerold Schuler

  • Dendritic cells as a tool to induce anergic and regulatory T cells.

    Helmut Jonuleit;Edgar Schmitt;Kerstin Steinbrink;Alexander H Enk

  • Dacarbazine (DTIC) versus vaccination with autologous peptide-pulsed dendritic cells (DC) in first-line treatment of patients with metastatic melanoma: a randomized phase III trial of the DC study group of the DeCOG

    D. Schadendorf;S. Ugurel;B. Schuler-Thurner;F.O. Nestle

  • CD4(+) and CD8(+) anergic T cells induced by interleukin-10-treated human dendritic cells display antigen-specific suppressor activity.

    Kerstin Steinbrink;Edith Graulich;Sebastian Kubsch;Jürgen Knop

  • An essential role for Langerhans cell-derived IL-1 beta in the initiation of primary immune responses in skin.

    A H Enk;V L Angeloni;M C Udey;S I Katz

  • Deep learning outperformed 136 of 157 dermatologists in a head-to-head dermoscopic melanoma image classification task

    Titus J. Brinker;Titus J. Brinker;Achim Hekler;Alexander H. Enk;Joachim Klode

  • Immature, but not inactive: the tolerogenic function of immature dendritic cells

    Karsten Mahnke;Edgar Schmitt;Laura Bonifaz;Alexander H Enk

  • Dendritic cells as mediators of tumor‐induced tolerance in metastatic melanoma

    Alexander H. Enk;Helmut Jonuleit;Joachim Saloga;Jürgen Knop

  • Induction of CD4+/CD25+ regulatory T cells by targeting of antigens to immature dendritic cells

    Karsten Mahnke;Yingjie Qian;Juergen Knop;Alexander H Enk

  • A comparison of two types of dendritic cell as adjuvants for the induction of melanoma-specific T-cell responses in humans following intranodal injection.

    Helmut Jonuleit;Andrea Giesecke‐Tuettenberg;Thomas Tüting;Beatrice Thurner‐Schuler

  • RAGE signaling sustains inflammation and promotes tumor development

    Christoffer Gebhardt;Astrid Riehl;Moritz Durchdewald;Julia Németh

Frequent Co-Authors

Jürgen Knop
Jürgen Knop Johannes Gutenberg University of Mainz
Karsten Mahnke
Karsten Mahnke Heidelberg University
Helmut Jonuleit
Helmut Jonuleit Johannes Gutenberg University of Mainz
Jochen Utikal
Jochen Utikal German Cancer Research Center
Dirk Schadendorf
Dirk Schadendorf University of Duisburg-Essen
Christof von Kalle
Christof von Kalle Charité - University Medicine Berlin
Axel Hauschild
Axel Hauschild Kiel University
Claus Garbe
Claus Garbe University of Tübingen
Gerold Schuler
Gerold Schuler University of Erlangen-Nuremberg
Edgar Schmitt
Edgar Schmitt Johannes Gutenberg University of Mainz

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