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Biology and Biochemistry

D-Index
53
Citations
9272
World Ranking
16248
National Ranking
6729

Overview

Marcus R. Clark is affiliated with the University of Chicago in the United States. Their research spans multiple intersecting fields with a focus on immunology and microbiology, medicine, and biochemistry, genetics, and molecular biology. The scientist has published extensively in these areas, contributing to the advancement of knowledge in immune cell function, systemic lupus erythematosus, and related biomedical topics.

Their main fields of study include:

  • Immunology and Microbiology
  • Medicine
  • Biochemistry, Genetics and Molecular Biology

Clark's research delves deeply into subfields such as immunology, molecular biology, rheumatology, radiology, nuclear medicine and imaging, and transplantation. This diverse expertise supports their wide-ranging studies on immune responses and tissue pathology.

Key subfields of study are:

  • Immunology
  • Molecular Biology
  • Rheumatology
  • Radiology, Nuclear Medicine and Imaging
  • Transplantation

Their research topics focus notably on T-cell and B-cell immunology, immune system therapies, inflammation mechanisms, and specific diseases such as lupus nephritis and cardiovascular diseases. Clark also investigates genomics, chromatin dynamics, and outcomes related to renal transplantation.

Main topics of work include:

  • T-cell and B-cell Immunology
  • Immunotherapy and Immune Responses
  • Immune Cell Function and Interaction
  • Systemic Lupus Erythematosus Research
  • Atherosclerosis and Cardiovascular Diseases
  • Genomics and Chromatin Dynamics
  • Renal Transplantation Outcomes and Treatments

Several frequent co-authors have collaborated extensively with Clark, reflecting longstanding research partnerships. These include Margaret Veselits, Junting Ai, Madeleine S. Durkee, Maryellen L. Giger, and Malay Mandal. The number of joint publications ranges from 11 to 18 with these colleagues.

Frequent co-authors:

  • Margaret Veselits
  • Junting Ai
  • Madeleine S. Durkee
  • Maryellen L. Giger
  • Malay Mandal

Clark's work appears in notable academic journals, often in immunology and biomedical sciences venues. The most common places of publication include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Immunology
  • Journal of Clinical Investigation
  • The Journal of Immunology
  • Cell Reports

Recent papers showcase a range of their research interests and publication years:

  • "Control of Early B Cell Development by the RNA N6-Methyladenosine Methylation" (2020) published in Cell Reports
  • "Kidney tissue hypoxia dictates T cell-mediated injury in murine lupus nephritis" (2020) published in Science Translational Medicine
  • "Novel specialized cell state and spatial compartments within the germinal center" (2020) published in Nature Immunology
  • "Artificial Intelligence and Cellular Segmentation in Tissue Microscopy Images" (2021) published in American Journal Of Pathology
  • "Specific in situ inflammatory states associate with progression to renal failure in lupus nephritis" (2022) published in Journal of Clinical Investigation

Best Publications

  • Signal Transduction by the B Cell Antigen Receptor and its Coreceptors

    J C Cambier;C M Pleiman;M R Clark

  • REGULATION OF SURFACE AND INTRACELLULAR EXPRESSION OF CTLA4 ON MOUSE T CELLS

    M L Alegre;P J Noel;B J Eisfelder;E Chuang

  • The B cell antigen receptor complex: association of Ig-alpha and Ig-beta with distinct cytoplasmic effectors

    Marcus R. Clark;Kerry S. Campbell;Andrius Kazlauskas;Sara A. Johnson

  • In Situ B Cell-Mediated Immune Responses and Tubulointerstitial Inflammation in Human Lupus Nephritis

    Anthony Chang;Scott G. Henderson;Daniel Brandt;Ni Liu

  • Orchestrating B cell lymphopoiesis through interplay of IL-7 receptor and pre-B cell receptor signalling

    Marcus R. Clark;Malay Mandal;Kyoko Ochiai;Harinder Singh

  • Predicting outcomes of lupus nephritis with tubulointerstitial inflammation and scarring

    Christine Hsieh;Anthony Chang;Daniel Brandt;Riteesha Guttikonda

  • Nonmitogenic Anti-CD3 Monoclonal Antibodies Deliver a Partial T Cell Receptor Signal and Induce Clonal Anergy

    Judith A. Smith;J. Yun Tso;Marcus R. Clark;Michael S. Cole

  • HS1 functions as an essential actin-regulatory adaptor protein at the immune synapse.

    Timothy S. Gomez;Sean D. McCarney;Esteban Carrizosa;Christine M. Labno

  • Mapping of sites on the Src family protein tyrosine kinases p55blk, p59fyn, and p56lyn which interact with the effector molecules phospholipase C-gamma 2, microtubule-associated protein kinase, GTPase-activating protein, and phosphatidylinositol 3-kinase.

    C. M. Pleiman;M. R. Clark;L. K. T. Gauen;S. Winitz

  • Cell Distance Mapping Identifies Functional T Follicular Helper Cells in Inflamed Human Renal Tissue

    Vladimir M. Liarski;Natalya Kaverina;Anthony Chang;Daniel Brandt

  • Epigenetic repression of the Igk locus by STAT5-mediated recruitment of the histone methyltransferase Ezh2.

    Malay Mandal;Sarah E Powers;Mark Maienschein-Cline;Elizabeth T Bartom

  • Therapeutic Targeting of the Cyclin D3:CDK4/6 Complex in T Cell Leukemia

    Catherine M. Sawai;Jacquelyn Freund;Philmo Oh;Delphine Ndiaye-Lobry

  • Analysis of Ig-alpha-tyrosine kinase interaction reveals two levels of binding specificity and tyrosine phosphorylated Ig-alpha stimulation of Fyn activity.

    M.R. Clark;S.A. Johnson;J.C. Cambier

  • Self-reactive IgE exacerbates interferon responses associated with autoimmunity

    Jill Henault;Jeffrey M Riggs;Jodi L Karnell;Vladimir M Liarski

  • A self-reinforcing regulatory network triggered by limiting IL-7 activates pre-BCR signaling and differentiation

    Kyoko Ochiai;Mark Maienschein-Cline;Malay Mandal;Joseph R Triggs

  • The Direct Recruitment of BLNK to Immunoglobulin α Couples the B-Cell Antigen Receptor to Distal Signaling Pathways

    Shara Kabak;Brian J. Skaggs;Michael R. Gold;Michael Affolter

  • Ikaros and Aiolos Inhibit Pre-B-Cell Proliferation by Directly Suppressing c-Myc Expression

    Shibin Ma;Simanta Pathak;Malay Mandal;Long Trinh

  • Modified anti-CD3 therapy in psoriatic arthritis: a phase I/II clinical trial.

    Tammy O. Utset;Julie A. Auger;Donna Peace;Robert A. Zivin

  • Cutting Edge: Signals from the B Lymphocyte Antigen Receptor Regulate MHC Class II Containing Late Endosomes

    Karyn Siemasko;Bartholomew J. Eisfelder;Edward Williamson;Shara Kabak

  • A unique function for cyclin D3 in early B cell development.

    A Byron Cooper;Catherine M Sawai;Ewa Sicinska;Sarah E Powers

Frequent Co-Authors

Maryellen L. Giger
Maryellen L. Giger University of Chicago
John C. Cambier
John C. Cambier University of Colorado Anschutz Medical Campus
Patrick C. Wilson
Patrick C. Wilson Cornell University
Iannis Aifantis
Iannis Aifantis New York University
Ronald Herbst
Ronald Herbst Biolojic Design
Jeffrey A. Bluestone
Jeffrey A. Bluestone University of California, San Francisco
M. Celeste Simon
M. Celeste Simon University of Pennsylvania
Harinder Singh
Harinder Singh University of Pittsburgh
David G. Schatz
David G. Schatz Yale University
Jane A. Skok
Jane A. Skok New York University

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