World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
65
Citations
11698
World Ranking
9389
National Ranking
4139

Overview

Janis K. Burkhardt is affiliated with the University of Pennsylvania in the United States. Their research spans multiple areas within immunology, medicine, and molecular biology, reflecting a diverse engagement with the biomedical sciences. The main fields of study for Burkhardt include Immunology and Microbiology, Medicine, and Biochemistry, Genetics and Molecular Biology. Within these broad fields, subfields of study focus on Immunology, Molecular Biology, Immunology and Allergy, Cell Biology, and Hematology.

Burkhardt's scientific work covers numerous topics, notably:

  • Cell Adhesion Molecules Research
  • T-cell and B-cell Immunology
  • Cellular Mechanics and Interactions
  • Immunotherapy and Immune Responses
  • Immunodeficiency and Autoimmune Disorders
  • Immune Cell Function and Interaction
  • CAR-T cell therapy research

Recent publications by Janis K. Burkhardt illustrate a focus on immune cell behavior, cellular mechanics, and immunotherapy. Notable papers include:

  • Antigen-independent activation enhances the efficacy of 4-1BB-costimulated CD22 CAR T cells (2021, Nature Medicine)
  • Mouse T cell priming is enhanced by maturation-dependent stiffening of the dendritic cell cortex (2020, eLife)
  • HEM1 deficiency disrupts mTORC2 and F-actin control in inherited immunodysregulatory disease (2020, Science)
  • Multiple actin networks coordinate mechanotransduction at the immunological synapse (2020, The Journal of Cell Biology)
  • Cryptosporidium rhoptry effector protein ROP1 injected during invasion targets the host cytoskeletal modulator LMO7 (2021, Cell Host & Microbe)

Frequent collaborators in their research include:

  • Nathan H. Roy
  • Daniel Blumenthal
  • Tanner F. Robertson
  • Ivan Maillard
  • Daniela Gómez

Janis K. Burkhardt has published extensively in several scientific journals and preprint archives. The most frequent publication venues are:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • The Journal of Cell Biology
  • Journal of Clinical Investigation
  • Blood
  • Molecular Immunology

Best Publications

  • Overexpression of the Dynamitin (p50) Subunit of the Dynactin Complex Disrupts Dynein-dependent Maintenance of Membrane Organelle Distribution

    Janis K. Burkhardt;Christophe J. Echeverri;Tommy Nilsson;Richard B. Vallee

  • Molecular ordering of the initial signaling events of CD95

    Alicia Algeciras-Schimnich;Le Shen;Bryan C. Barnhart;Andrea E. Murmann

  • The actin cytoskeleton in T cell activation.

    Janis K. Burkhardt;Esteban Carrizosa;Meredith H. Shaffer

  • ERM-dependent movement of CD43 defines a novel protein complex distal to the immunological synapse.

    Eric J. Allenspach;Patrick Cullinan;Jiankun Tong;Qizhi Tang

  • Molecular Requirements for Bi-directional Movement of Phagosomes Along Microtubules

    Ariel Blocker;Fedor F. Severin;Janis K. Burkhardt;James B. Bingham

  • The WAVE2 Complex Regulates Actin Cytoskeletal Reorganization and CRAC-Mediated Calcium Entry during T Cell Activation

    Jeffrey C. Nolz;Timothy S. Gomez;Peimin Zhu;Shuixing Li

  • Membrane biogenesis during B cell differentiation: most endoplasmic reticulum proteins are expressed coordinately.

    David L. Wiest;Janis K. Burkhardt;Susan Hester;Michael Hortsch

  • HS1 functions as an essential actin-regulatory adaptor protein at the immune synapse.

    Timothy S. Gomez;Sean D. McCarney;Esteban Carrizosa;Christine M. Labno

  • Spatial organization of signal transduction molecules in the NK cell immune synapses during MHC class I-regulated noncytolytic and cytolytic interactions.

    Yatin M. Vyas;Kamini M. Mehta;Margaret Morgan;Hina Maniar

  • F-actin polymerization and retrograde flow drive sustained PLCγ1 signaling during T cell activation

    Alexander Babich;Shuixing Li;Roddy S. O'Connor;Michael C. Milone

  • Involvement of microtubule motors in basolateral and apical transport in kidney cells

    Frank Lafont;Janis K. Burkhardt;Kai Simons

  • SLP-76 Coordinates Nck-Dependent Wiskott-Aldrich Syndrome Protein Recruitment with Vav-1/Cdc42-Dependent Wiskott-Aldrich Syndrome Protein Activation at the T Cell-APC Contact Site

    Rong Zeng;Judy L. Cannon;Robert T. Abraham;Michael Way

  • The lytic granules of natural killer cells are dual-function organelles combining secretory and pre-lysosomal compartments.

    J K Burkhardt;S Hester;C K Lapham;Y Argon

  • F-actin flow drives affinity maturation and spatial organization of LFA-1 at the immunological synapse

    William A. Comrie;Alexander Babich;Janis K. Burkhardt

  • Actin foci facilitate activation of the phospholipase C-γ in primary T lymphocytes via the WASP pathway

    Sudha Kumari;David Depoil;David Depoil;Roberta Martinelli;Edward Judokusumo

  • The dendritic cell cytoskeleton promotes T cell adhesion and activation by constraining ICAM-1 mobility

    William A. Comrie;Shuixing Li;Sarah Boyle;Janis K. Burkhardt

  • WASP Recruitment to the T Cell:APC Contact Site Occurs Independently of Cdc42 Activation

    Judy L Cannon;Christine M Labno;Gerra Bosco;Abhinav Seth

  • Dynamin 2 regulates T cell activation by controlling actin polymerization at the immunological synapse

    Timothy S Gomez;Michael J Hamann;Sean McCarney;Doris N Savoy

  • A standard for calibration and shading correction of a fluorescence microscope.

    Michael A. Model;Janis K. Burkhardt

  • Kinase-Independent Functions for Itk in TCR-Induced Regulation of Vav and the Actin Cytoskeleton

    Derek Dombroski;Richard A. Houghtling;Christine M. Labno;Patricia Precht

Frequent Co-Authors

Yair Argon
Yair Argon Children's Hospital of Philadelphia
Daniel A. Hammer
Daniel A. Hammer University of Pennsylvania
Gareth Griffiths
Gareth Griffiths University of Oslo
Anne I. Sperling
Anne I. Sperling University of Virginia
Richard A. Gibbs
Richard A. Gibbs Baylor College of Medicine
Pamela L. Schwartzberg
Pamela L. Schwartzberg National Institutes of Health
Michael L. Dustin
Michael L. Dustin University of Oxford
Shalini N. Jhangiani
Shalini N. Jhangiani Baylor College of Medicine
Donna M. Muzny
Donna M. Muzny Baylor College of Medicine

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Best Scientists Citing Janis K. Burkhardt

Trending Scientists