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Biology and Biochemistry

D-Index
104
Citations
30964
World Ranking
1281
National Ranking
752

Overview

Erika L.F. Holzbaur is affiliated with the University of Pennsylvania in the United States. Their research focuses primarily on biochemistry, genetics, and molecular biology, with significant work also in medicine. Their scholarly output encompasses various subfields, including cell biology, molecular biology, epidemiology, cellular and molecular neuroscience, and neurology.

Their research covers several key topics, including autophagy in disease and therapy, microtubule and mitosis dynamics, cellular transport and secretion, mitochondrial function and pathology, Parkinson's disease mechanisms and treatments, endoplasmic reticulum stress and disease, and genetic neurodegenerative diseases.

Recent notable publications by Holzbaur and collaborators include the following:

  • A reference human induced pluripotent stem cell line for large-scale collaborative studies, 2022, Cell Stem Cell
  • Actin cables and comet tails organize mitochondrial networks in mitosis, 2021, Nature
  • Increased LRRK2 kinase activity alters neuronal autophagy by disrupting the axonal transport of autophagosomes, 2021, Current Biology
  • Selective motor activation in organelle transport along axons, 2022, Nature Reviews Molecular Cell Biology
  • Degradation of engulfed mitochondria is rate-limiting in Optineurin-mediated mitophagy in neurons, 2020, eLife

Holzbaur frequently collaborates with a number of coauthors, including:

  • C. Alexander Boecker
  • Sydney E. Cason
  • Dan Dou
  • Chantell S. Evans
  • Juliet Goldsmith

Their work has been published in several prominent scientific venues, with the highest counts in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Zenodo (CERN European Organization for Nuclear Research)
  • Trends in Cell Biology
  • Nature Communications
  • Autophagy

Best Publications

  • Mutant dynactin in motor neuron disease.

    Imke Puls;Catherine Jonnakuty;Bernadette H. LaMonte;Erika L.F. Holzbaur

  • Differential regulation of dynein and kinesin motor proteins by tau.

    Ram Dixit;Jennifer L. Ross;Yale E. Goldman;Erika L. F. Holzbaur

  • Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation

    Yvette C. Wong;Erika L. F. Holzbaur

  • Autophagosomes initiate distally and mature during transport toward the cell soma in primary neurons.

    Sandra Maday;Karen E. Wallace;Erika L.F. Holzbaur

  • AXONAL TRANSPORT: CARGO-SPECIFIC MECHANISMS OF MOTILITY AND REGULATION

    Sandra Maday;Alison E. Twelvetrees;Armen J. Moughamian;Erika L.F. Holzbaur

  • Disruption of dynein/dynactin inhibits axonal transport in motor neurons causing late-onset progressive degeneration.

    Bernadette H LaMonte;Karen E Wallace;Beth A Holloway;Spencer S Shelly

  • Cytoplasmic dynein and dynactin in cell division and intracellular transport.

    Sher Karki;Erika Lf Holzbaur

  • Axonal transport and neurodegenerative disease.

    Erica Chevalier-Larsen;Erika L.F. Holzbaur

  • Motor Coordination via a Tug-of-War Mechanism Drives Bidirectional Vesicle Transport

    Adam G. Hendricks;Eran Perlson;Jennifer L. Ross;Harry W. Schroeder

  • Dyneins: Molecular Structure and Cellular Function

    E. L. F. Holzbaur;R. B. Vallee

  • Affinity Chromatography Demonstrates a Direct Binding between Cytoplasmic Dynein and the Dynactin Complex

    Sher Karki;Erika L.F. Holzbaur

  • Autophagosome biogenesis in primary neurons follows an ordered and spatially regulated pathway

    Sandra Maday;Erika L.F. Holzbaur

  • Huntingtin-associated protein 1 (HAP1) interacts with the p150Glued subunit of dynactin.

    Simone Engelender;Alan H. Sharp;Veronica Colomer;Mariko K. Tokito

  • Retrograde axonal transport: pathways to cell death?

    Eran Perlson;Sandra Maday;Meng-meng Fu;Armen J. Moughamian

  • The Regulation of Autophagosome Dynamics by Huntingtin and HAP1 Is Disrupted by Expression of Mutant Huntingtin, Leading to Defective Cargo Degradation

    Yvette C. Wong;Erika L. F. Holzbaur

  • The p150Glued component of the dynactin complex binds to both microtubules and the actin-related protein centractin (Arp-1).

    Clare M. Waterman-Storer;Sher Karki;Erika L. F. Holzbaur

  • Microtubule motors at the intersection of trafficking and transport

    Juliane P. Caviston;Erika L.F. Holzbaur

  • Dynein binds to β-catenin and may tether microtubules at adherens junctions

    Lee A. Ligon;Sher Karki;Mariko Tokito;Erika L. F. Holzbaur

  • Huntingtin facilitates dynein/dynactin-mediated vesicle transport

    Juliane P. Caviston;Jennifer L. Ross;Sheila M. Antony;Mariko Tokito

  • Compartment-Specific Regulation of Autophagy in Primary Neurons.

    Sandra Maday;Erika L. F. Holzbaur

Frequent Co-Authors

Yale E. Goldman
Yale E. Goldman University of Pennsylvania
Roberto Dominguez
Roberto Dominguez University of Pennsylvania
Harry W. Schroeder
Harry W. Schroeder University of Alabama at Birmingham
Carsten Janke
Carsten Janke Institute Curie
Michaela Schweizer
Michaela Schweizer Universität Hamburg
Kenneth H. Fischbeck
Kenneth H. Fischbeck National Institutes of Health
John H. Wolfe
John H. Wolfe University of Pennsylvania
Richard B. Vallee
Richard B. Vallee Columbia University
Clare M. Waterman-Storer
Clare M. Waterman-Storer National Institutes of Health
Christopher B. Murray
Christopher B. Murray University of Pennsylvania

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