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Biology and Biochemistry

D-Index
60
Citations
13640
World Ranking
11903
National Ranking
5111

Overview

Roberto Dominguez is affiliated with the University of Pennsylvania in the United States and has contributed extensively to the field of Biochemistry, Genetics and Molecular Biology. Their research spans numerous subfields including Molecular Biology, Cell Biology, Cardiology and Cardiovascular Medicine, Biophysics, and Structural Biology.

Their work addresses a range of topics, notably:

  • Cellular Mechanics and Interactions
  • Cardiomyopathy and Myosin Studies
  • Advanced Electron Microscopy Techniques and Applications
  • Advanced Fluorescence Microscopy Techniques
  • Muscle Physiology and Disorders
  • Force Microscopy Techniques and Applications
  • Heat shock proteins research

Recent publications by Dominguez include:

  • "Structures of the free and capped ends of the actin filament," 2023, Science
  • "Nucleation, stabilization, and disassembly of branched actin networks," 2021, Trends in Cell Biology
  • "Sequential dynein effectors regulate axonal autophagosome motility in a maturation-dependent pathway," 2021, The Journal of Cell Biology
  • "Cryo-EM structure of NPF-bound human Arp2/3 complex and activation mechanism," 2020, Science Advances
  • "A tunable LIC1-adaptor interaction modulates dynein activity in a cargo-specific manner," 2020, Nature Communications

Dominguez frequently publishes in several venues, with multiple contributions found in:

  • EMPIAR dataset
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Science Advances
  • Journal of Biological Chemistry

Collaborators who have co-authored numerous papers with Dominguez include:

  • Grzegorz Rębowski
  • Małgorzata Boczkowska
  • Peter J. Carman
  • Kyle R. Barrie
  • E. Michael Ostap

In addition to journal articles, Dominguez has contributed to book publications, including a title published by Springer International Publishing: EU Foreign Policy Towards Latin America (2024).

Best Publications

  • Actin structure and function.

    Roberto Dominguez;Kenneth C. Holmes

  • Crystal structure of a vertebrate smooth muscle myosin motor domain and its complex with the essential light chain: visualization of the pre-power stroke state.

    Roberto Dominguez;Yelena Freyzon;Kathleen M Trybus;Carolyn Cohen

  • The crystal structure of uncomplexed actin in the ADP state.

    Ludovic R. Otterbein;Philip Graceffa;Roberto Dominguez

  • Structural basis of protein phosphatase 1 regulation

    Mohammed Terrak;Frederic Kerff;Knut Langsetmo;Terence Tao

  • Regulation of actin cytoskeleton dynamics in cells

    Sung Haeng Lee;Roberto Dominguez

  • Actin-bound structures of Wiskott–Aldrich syndrome protein (WASP)-homology domain 2 and the implications for filament assembly

    David Chereau;Frederic Kerff;Philip Graceffa;Zenon Grabarek

  • Actin-binding proteins--a unifying hypothesis.

    Roberto Dominguez

  • DECIPHERING THE DESIGN OF THE TROPOMYOSIN MOLECULE.

    Jerry H. Brown;Kyoung Hee Kim;Gyo Jun;Gyo Jun;Norma J. Greenfield

  • Structural basis for the recruitment of profilin–actin complexes during filament elongation by Ena/VASP

    François Ferron;Grzegorz Rebowski;Sung Haeng Lee;Roberto Dominguez

  • Capping protein regulators fine-tune actin assembly dynamics

    Marc Edwards;Adam Zwolak;Dorothy A. Schafer;David Sept

  • Crystal Structure of Monomeric Actin in the ATP State STRUCTURAL BASIS OF NUCLEOTIDE-DEPENDENT ACTIN DYNAMICS

    Philip Graceffa;Roberto Dominguez

  • Leiomodin Is an Actin Filament Nucleator in Muscle Cells

    David Chereau;Malgorzata Boczkowska;Aneta Skwarek-Maruszewska;Ikuko Fujiwara

  • The Cytoskeleton–Autophagy Connection

    David J. Kast;Roberto Dominguez

  • The crystal structure of endoglucanase CelA, a family 8 glycosyl hydrolase from Clostridium thermocellum.

    Pedro M Alzari;Hélè ne Souchon;Roberto Dominguez

  • A common protein fold and similar active site in two distinct families of beta-glycanases.

    Roberto Dominguez;Hélène Souchon;Silvia Spinelli;Zbigniew Dauter

  • Mechanism of actin filament bundling by fascin.

    Silvia Jansen;Agnieszka Collins;Changsong Yang;Grzegorz Rebowski

  • Structures of four Ca2+-bound troponin C at 2.0 A resolution: further insights into the Ca2+-switch in the calmodulin superfamily.

    Anne Houdusse;Michael L Love;Roberto Dominguez;Zenon Grabarek

  • Crystal structures of the vitamin D-binding protein and its complex with actin: structural basis of the actin-scavenger system.

    Ludovic R. Otterbein;Christophe Cosio;Philip Graceffa;Roberto Dominguez

  • Structural Basis for the Actin-Binding Function of Missing-in-Metastasis

    Sung Haeng Lee;Frederic Kerff;David Chereau;François Ferron

  • Actin filament nucleation and elongation factors--structure-function relationships.

    Roberto Dominguez

Frequent Co-Authors

Erika L.F. Holzbaur
Erika L.F. Holzbaur University of Pennsylvania
Tatyana Svitkina
Tatyana Svitkina University of Pennsylvania
Thomas Arnesen
Thomas Arnesen University of Bergen
Pekka Lappalainen
Pekka Lappalainen University of Helsinki
David R. Kovar
David R. Kovar University of Chicago
Michael J. Greenberg
Michael J. Greenberg Washington University in St. Louis
Pedro M. Alzari
Pedro M. Alzari Institut Pasteur
William Lehman
William Lehman Boston University
Kathleen G. Morgan
Kathleen G. Morgan Boston University
David A. Weitz
David A. Weitz Harvard University

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