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Biology and Biochemistry

D-Index
66
Citations
20597
World Ranking
8506
National Ranking
3825

Overview

Tatyana Svitkina is a researcher affiliated with the University of Pennsylvania in the United States. Their academic work primarily spans biochemistry, genetics, molecular biology, and medicine. Within these broad fields, they focus especially on cell biology, molecular biology, immunology, allergy, cardiology, cardiovascular medicine, and biomedical engineering.

The main research topics covered by Svitkina include cellular mechanics and interactions, cell adhesion molecules, microtubule and mitosis dynamics, cardiomyopathy and myosin studies, cellular transport and secretion, 3D printing in biomedical research, and fungal and yeast genetics research.

Key recent publications by Svitkina and their colleagues are:

  • Actin Cell Cortex: Structure and Molecular Organization (2020) in Trends in Cell Biology
  • Dynamin regulates the dynamics and mechanical strength of the actin cytoskeleton as a multifilament actin-bundling protein (2020) in Nature Cell Biology
  • HRS phosphorylation drives immunosuppressive exosome secretion and restricts CD8+ T-cell infiltration into tumors (2022) in Nature Communications
  • A phosphoinositide switch mediates exocyst recruitment to multivesicular endosomes for exosome secretion (2023) in Nature Communications
  • Branched actin networks are assembled on microtubules by adenomatous polyposis coli for targeted membrane protrusion (2020) in The Journal of Cell Biology

Their frequent coauthors include Changsong Yang, Ruihui Zhang, Delgermaa Luvsanjav, Pratima Pandey, and Benjamin Ravaux. These collaborations highlight a research network with a focus on cytoskeletal dynamics and cellular processes.

Svitkina's work is regularly published in several venues, with multiple contributions to Nature Communications and bioRxiv (Cold Spring Harbor Laboratory). Other frequent publication venues include Nature Cell Biology, Current Biology, and Molecular Biology of the Cell.

Best Publications

  • Arp2/3 complex and actin depolymerizing factor/cofilin in dendritic organization and treadmilling of actin filament array in lamellipodia.

    Tatyana M. Svitkina;Gary G. Borisy

  • Visualization of the intracellular behavior of HIV in living cells

    David McDonald;Marie A. Vodicka;Ginger Lucero;Tatyana M. Svitkina

  • Antagonism between Ena/VASP Proteins and Actin Filament Capping Regulates Fibroblast Motility

    James E. Bear;Tatyana M. Svitkina;Matthias Krause;Dorothy A. Schafer

  • Mechanism of filopodia initiation by reorganization of a dendritic network

    Tatyana M. Svitkina;Elena A. Bulanova;Oleg Y. Chaga;Danijela M. Vignjevic

  • Analysis of the Actin–Myosin II System in Fish Epidermal Keratocytes: Mechanism of Cell Body Translocation

    Tatyana M. Svitkina;Alexander B. Verkhovsky;Kyle M. McQuade;Gary G. Borisy

  • The Actin Cytoskeleton and Actin-Based Motility

    Tatyana Svitkina

  • Actin machinery: pushing the envelope.

    Gary G Borisy;Tatyana M Svitkina

  • Self-polarization and directional motility of cytoplasm

    Alexander B. Verkhovsky;Tatyana M. Svitkina;Gary G. Borisy

  • Role of fascin in filopodial protrusion

    Danijela Vignjevic;Shin Ichiro Kojima;Yvonne Aratyn;Oana Danciu

  • Molecular Architecture of Synaptic Actin Cytoskeleton in Hippocampal Neurons Reveals a Mechanism of Dendritic Spine Morphogenesis

    Farida Korobova;Tatyana M. Svitkina

  • Lamellipodial versus filopodial mode of the actin nanomachinery: pivotal role of the filament barbed end.

    Marisan R. Mejillano;Shin-ichiro Kojima;Derek Anthony Applewhite;Frank B. Gertler

  • Plectin sidearms mediate interaction of intermediate filaments with microtubules and other components of the cytoskeleton.

    T M Svitkina;A B Verkhovsky;G G Borisy

  • Myosin II filament assemblies in the active lamella of fibroblasts: their morphogenesis and role in the formation of actin filament bundles.

    A B Verkhovsky;T M Svitkina;G G Borisy

  • Novel Roles of Formin mDia2 in Lamellipodia and Filopodia Formation in Motile Cells

    Changsong Yang;Lubov Czech;Silke Gerboth;Shin-ichiro Kojima

  • Critical Role of Ena/VASP Proteins for Filopodia Formation in Neurons and in Function Downstream of Netrin-1

    Cecile Lebrand;Erik W Dent;Geraldine A Strasser;Lorene M Lanier

  • Arp2/3 Complex Is Important for Filopodia Formation, Growth Cone Motility, and Neuritogenesis in Neuronal Cells

    Farida Korobova;Tatyana Svitkina

  • Formation of filopodia-like bundles in vitro from a dendritic network.

    Danijela Vignjevic;Defne Yarar;Matthew D. Welch;John Peloquin

  • Natural Killer Cell Lytic Granule Secretion Occurs through a Pervasive Actin Network at the Immune Synapse

    Gregory D. Rak;Emily M. Mace;Pinaki P. Banerjee;Tatyana Svitkina

  • Ena/VASP Proteins Have an Anti-Capping Independent Function in Filopodia Formation

    Derek A. Applewhite;Melanie Barzik;Shin-ichiro Kojima;Tatyana M. Svitkina

  • Structural Organization of the Actin Cytoskeleton at Sites of Clathrin-Mediated Endocytosis

    Agnieszka Collins;Anthony Warrington;Kenneth A. Taylor;Tatyana Svitkina

Frequent Co-Authors

Gary G. Borisy
Gary G. Borisy ADA Forsyth Institute
Roberto Dominguez
Roberto Dominguez University of Pennsylvania
Erfei Bi
Erfei Bi University of Pennsylvania
Richard A. Flavell
Richard A. Flavell Yale University
Giorgio Scita
Giorgio Scita FIRC Institute of Molecular Oncology
James E. Bear
James E. Bear University of North Carolina at Chapel Hill
Gianluca Gallo
Gianluca Gallo Temple University
Wei Guo
Wei Guo University of Pennsylvania
Paul A. Janmey
Paul A. Janmey University of Pennsylvania

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