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D-Index & Metrics

Biology and Biochemistry

D-Index
68
Citations
20978
World Ranking
7676
National Ranking
3499

Overview

Wei Guo is affiliated with the University of Pennsylvania in the United States and has a research focus spanning biochemistry, genetics, molecular biology, and medicine. Their work is highly interdisciplinary, integrating molecular biology, oncology, immunology, cell biology, and biomedical engineering.

Wei Guo's primary research topics include:

  • Extracellular vesicles in disease
  • Immunotherapy and immune responses
  • CAR-T cell therapy research
  • Cancer immunotherapy and biomarkers
  • Cellular mechanics and interactions
  • Immune cell function and interaction
  • MicroRNA in disease regulation

Recent publications by Wei Guo cover several areas of cancer biology and cellular interactions. Notable papers include:

  • "Epigenetic regulation of ferroptosis via ETS1/miR-23a-3p/ACSL4 axis mediates sorafenib resistance in human hepatocellular carcinoma," 2022, Journal of Experimental & Clinical Cancer Research
  • "Stiff matrix induces exosome secretion to promote tumour growth," 2023, Nature Cell Biology
  • "Desmoplastic stroma restricts T cell extravasation and mediates immune exclusion and immunosuppression in solid tumors," 2023, Nature Communications
  • "ICAM-1-mediated adhesion is a prerequisite for exosome-induced T cell suppression," 2022, Developmental Cell
  • "HRS phosphorylation drives immunosuppressive exosome secretion and restricts CD8+ T-cell infiltration into tumors," 2022, Nature Communications

Wei Guo has contributed frequently to leading journals and publication venues such as:

  • Nature Communications (4 publications)
  • bioRxiv (Cold Spring Harbor Laboratory) (4 publications)
  • Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature (4 publications)
  • Cell Reports (3 publications)
  • Nature Cell Biology (2 publications)

Collaboration is a significant aspect of Guo's scientific work. Frequent co-authors include Xiaowei Xu, Meenhard Herlyn, Wenqun Zhong, Ziyan Yu, and Jingbo Yang. These collaborations reflect Guo's integrated approach to complex biomedical problems.

Best Publications

  • Exosomal PD-L1 Contributes to Immunosuppression and is Associated with anti-PD-1 Response

    Gang Chen;Alexander C. Huang;Wei Zhang;Wei Zhang;Gao Zhang

  • Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells

    Ömer H. Yilmaz;Riccardo Valdez;Brian K. Theisen;Wei Guo

  • T2Rs function as bitter taste receptors.

    Jayaram Chandrashekar;Ken L Mueller;Mark A Hoon;Elliot Adler

  • Both the Establishment and the Maintenance of Neuronal Polarity Require Active Mechanisms: Critical Roles of GSK-3β and Its Upstream Regulators

    Hui Jiang;Wei Guo;Xinhua Liang;Yi Rao;Yi Rao

  • The exocyst complex in polarized exocytosis.

    Bing He;Wei Guo

  • The locust genome provides insight into swarm formation and long-distance flight

    Xianhui Wang;Xiaodong Fang;Pengcheng Yang;Xuanting Jiang

  • Coordination of Rab8 and Rab11 in primary ciliogenesis

    Andreas Knödler;Shanshan Feng;Jian Zhang;Xiaoyu Zhang

  • Spatial regulation of the exocyst complex by Rho1 GTPase

    Wei Guo;Wei Guo;Fuyuhiko Tamanoi;Peter Novick

  • Exo70 interacts with phospholipids and mediates the targeting of the exocyst to the plasma membrane

    Bing He;Fengong Xi;Xiaoyu Zhang;Jian Zhang

  • An ESRP‐regulated splicing programme is abrogated during the epithelial–mesenchymal transition

    Claude C Warzecha;Peng Jiang;Karine Amirikian;Kimberly A Dittmar

  • A protein interaction map for cell polarity development

    Becky L. Drees;Bryan Sundin;Elizabeth Brazeau;Juliane P. Caviston

  • Cdc42 interacts with the exocyst and regulates polarized secretion.

    Xiaoyu Zhang;Erfei Bi;Peter Novick;Lilin Du

  • Acquired cancer stem cell phenotypes through Oct4-mediated dedifferentiation

    Suresh M. Kumar;Shujing Liu;Hezhe Lu;Hongtao Zhang

  • The Exocyst Complex in Polarized Exocytosis

    Shu-Chan Hsu;Daniel TerBush;Mathew Abraham;Wei Guo

  • Membrane association and functional regulation of Sec3 by phospholipids and Cdc42.

    Xiaoyu Zhang;Kelly Orlando;Bing He;Fengong Xi

  • CSP and Takeout Genes Modulate the Switch between Attraction and Repulsion during Behavioral Phase Change in the Migratory Locust

    Wei-Feng Guo;Xianhui Wang;Zongyuan Ma;Liang Xue

  • Phosphatidylinositol 4,5-Bisphosphate Mediates the Targeting of the Exocyst to the Plasma Membrane for Exocytosis in Mammalian Cells

    Jianglan Liu;Xiaofeng Zuo;Peng Yue;Wei Guo

  • The Exocyst at a Glance

    Bin Wu;Wei Guo

  • Exo70 interacts with the Arp2/3 complex and regulates cell migration

    Xiaofeng Zuo;Jian Zhang;Ying Zhang;Shu-Chan Hsu

  • Genome-wide Association Analysis of Blood-Pressure Traits in African-Ancestry Individuals Reveals Common Associated Genes in African and Non-African Populations

    Nora Franceschini;Ervin Fox;Zhaogong Zhang;Zhaogong Zhang;Todd L. Edwards

Frequent Co-Authors

Xiaowei Xu
Xiaowei Xu University of Pennsylvania
Gordon B. Mills
Gordon B. Mills Oregon Health & Science University
Peter Novick
Peter Novick University of California, San Diego
Yiling Lu
Yiling Lu The University of Texas MD Anderson Cancer Center
Lynn M. Schuchter
Lynn M. Schuchter University of Pennsylvania
Meenhard Herlyn
Meenhard Herlyn The Wistar Institute
Paul I. W. de Bakker
Paul I. W. de Bakker Vertex Pharmaceuticals (United Kingdom)
Nilesh J. Samani
Nilesh J. Samani University of Leicester
Daniel I. Chasman
Daniel I. Chasman Brigham and Women's Hospital
Eric Boerwinkle
Eric Boerwinkle The University of Texas Health Science Center at Houston

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