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Kent J. Weinhold

Kent J. Weinhold

D-Index & Metrics

Immunology

D-Index
78
Citations
23493
World Ranking
1747
National Ranking
860

Medicine

D-Index
78
Citations
23493
World Ranking
18002
National Ranking
8974

Overview

Kent J. Weinhold is affiliated with Duke University in the United States and has a research focus spanning medicine, immunology, and microbiology. Their work includes a significant body of publications related to oncology, immunology, molecular biology, genetics, and surgery. Weinhold's contributions primarily explore cancer immunotherapy and biomarkers, immune cell function and interaction, as well as immunotherapy and immune responses.

Their research encompasses several important topics, notably:

  • Cancer Immunotherapy and Biomarkers
  • Immune Cell Function and Interaction
  • Immunotherapy and Immune Responses
  • CAR-T cell therapy research
  • Lung Cancer Research Studies
  • Chronic Lymphocytic Leukemia Research
  • Glioma Diagnosis and Treatment

Weinhold has published in a range of scientific journals, with frequent appearances in the following venues:

  • Journal of Clinical Oncology
  • UNC Libraries
  • Frontiers in Immunology
  • Clinical Cancer Research
  • Journal for ImmunoTherapy of Cancer

Collaborations are a notable aspect of Weinhold's research, working repeatedly with several co-authors:

  • Janet Staats
  • John H. Sampson
  • Scott Antonia
  • Jennifer Enzor
  • Simon G. Gregory

Among recent papers, Weinhold's publication record includes studies focused on immunotherapy and cancer treatment methodologies:

  • Safety and efficacy of pembrolizumab, radiation therapy, and surgery versus radiation therapy and surgery for stage III soft tissue sarcoma of the extremity (SU2C-SARC032): an open-label, randomised clinical trial (2024, The Lancet)
  • FlowKit: A Python Toolkit for Integrated Manual and Automated Cytometry Analysis Workflows (2021, Frontiers in Immunology)
  • A randomized phase 2 trial of pembrolizumab versus pembrolizumab and acalabrutinib in patients with platinum-resistant metastatic urothelial cancer (2020, Cancer)
  • A phase 2 trial of avelumab in men with aggressive-variant or neuroendocrine prostate cancer (2022, Prostate Cancer and Prostatic Diseases)
  • Wnt activation promotes memory T cell polyfunctionality via epigenetic regulator PRMT1 (2022, Journal of Clinical Investigation)

The breadth of Weinhold's work is anchored in therapeutic strategies within oncology and immune system modulation, integrating clinical trials and bioinformatics tools. Their studies often involve novel combinations of immunotherapeutic agents and provide insights into the immune mechanisms relevant to cancer treatment.

Best Publications

  • 3'-Azido-3'-deoxythymidine (BW A509U): an antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy-associated virus in vitro.

    H Mitsuya;K J Weinhold;P A Furman;M H St Clair

  • Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase.

    P A Furman;J A Fyfe;M H St Clair;K Weinhold

  • ADMINISTRATION OF 3'-AZIDO-3'-DEOXYTHYMIDINE, AN INHIBITOR OF HTLV-III/LAV REPLICATION, TO PATIENTS WITH AIDS OR AIDS-RELATED COMPLEX

    Robert Yarchoan;Kent J. Weinhold;H. Kim Lyerly;Edward Gelmann

  • Initial B-Cell Responses to Transmitted Human Immunodeficiency Virus Type 1: Virion-Binding Immunoglobulin M (IgM) and IgG Antibodies Followed by Plasma Anti-gp41 Antibodies with Ineffective Control of Initial Viremia

    Georgia D. Tomaras;Nicole L. Yates;Pinghuang Liu;Li Qin

  • Conserved sequence and structural elements in the HIV-1 principal neutralizing determinant.

    G J LaRosa;J P Davide;K Weinhold;J A Waterbury

  • The first T cell response to transmitted/founder virus contributes to the control of acute viremia in HIV-1 infection

    Nilu Goonetilleke;Michael K.P. Liu;Jesus F. Salazar-Gonzalez;Guido Ferrari

  • Type-specific neutralization of the human immunodeficiency virus with antibodies to env-encoded synthetic peptides

    Thomas J. Palker;Michael E. Clark;Alphonse J. Langlois;Thomas J. Matthews

  • T-Cell Exhaustion Signatures Vary with Tumor Type and Are Severe in Glioblastoma

    Karolina Woroniecka;Pakawat Chongsathidkiet;Kristen Rhodin;Hanna Kemeny

  • HTLV-III/LAV-neutralizing antibodies to an E. coli-produced fragment of the virus envelope

    SD Putney;TJ Matthews;WG Robey;DL Lynn

  • A controlled trial of early versus late treatment with zidovudine in symptomatic human immunodeficiency virus infection. Results of the Veterans Affairs Cooperative Study.

    Hamilton Jd;Hartigan Pm;Simberkoff Ms;Day Pl

  • 3'-azido-3'-deoxythymidine triphosphate as an inhibitor and substrate of purified human immunodeficiency virus reverse transcriptase

    M H St Clair;C A Richards;T Spector;K J Weinhold

  • Human T-cell lymphotropic virus IIIB glycoprotein (gp120) bound to CD4 determinants on normal lymphocytes and expressed by infected cells serves as target for immune attack

    H K Lyerly;T J Matthews;A J Langlois;D P Bolognesi

  • Interaction between the human T-cell lymphotropic virus type IIIB envelope glycoprotein gp120 and the surface antigen CD4: role of carbohydrate in binding and cell fusion

    T J Matthews;K J Weinhold;H K Lyerly;A J Langlois

  • Clade B-Based HIV-1 Vaccines Elicit Cross-Clade Cytotoxic T Lymphocyte Reactivities in Uninfected Volunteers

    Guido Ferrari;Will Humphrey;M. Juliana McElrath;Jean–Louis Excler

  • Immune Responses to Human Immunodeficiency Virus (HIV) Type 1 Induced by Canarypox Expressing HIV-1MN gp120, HIV-1SF2 Recombinant gp120, or Both Vaccines in Seronegative Adults

    Mary Lou Clements-Mann;Kent Weinhold;Thomas J. Matthews;Barney S. Graham

  • Standardization of cytokine flow cytometry assays

    Holden T Maecker;Aline Rinfret;Patricia D'Souza;Janice Darden

  • HIV-1 GP120-mediated immune suppression and lymphocyte destruction in the absence of viral infection.

    K J Weinhold;H K Lyerly;S D Stanley;A A Austin

  • High-throughput quantitative analysis of HIV-1 and SIV-specific ADCC-mediating antibody responses.

    Justin Pollara;Lydia Hart;Faraha Brewer;Joy Pickeral

  • A Canarypox Vaccine Expressing Multiple Human Immunodeficiency Virus Type 1 Genes Given Alone or with Rgp120 Elicits Broad and Durable CD8+ Cytotoxic T Lymphocyte Responses in Seronegative Volunteers

    Thomas G. Evans;Michael C. Keefer;Kent J. Weinhold;Mark Wolff

  • Induction of immune responses to HIV-1 by canarypox virus (ALVAC) HIV-1 and gp120 SF-2 recombinant vaccines in uninfected volunteers. NIAID AIDS Vaccine Evaluation Group.

    Robert B. Belshe;Geoffrey J. Gorse;Mark J. Mulligan;Thomas G. Evans

  • Analysis of the adult thymus in reconstitution of T lymphocytes in HIV-1 infection

    Barton F. Haynes;Laura P. Hale;Kent J. Weinhold;Dhavalkumar D. Patel

  • Human Immunodeficiency Virus Type 1 gp41 Antibodies That Mask Membrane Proximal Region Epitopes: Antibody Binding Kinetics, Induction, and Potential for Regulation in Acute Infection

    S. Munir Alam;Richard M. Scearce;Robert J. Parks;Kelly Plonk

  • Safety and immunogenicity of a canarypox-vectored human immunodeficiency virus Type 1 vaccine with or without gp120: a phase 2 study in higher- and lower-risk volunteers.

    Robert B. Belshe;Cladd Stevens;Geoffrey J. Gorse;Susan Buchbinder

  • Characterization of functional and phenotypic changes in anti-Gag vaccine-induced T cell responses and their role in protection after HIV-1 infection

    Michael R. Betts;Barbara Exley;David A. Price;Anju Bansal

  • QS-21 promotes an adjuvant effect allowing for reduced antigen dose during HIV-1 envelope subunit immmunization in humans

    Thomas G. Evans;M.Juliana McElrath;Tom Matthews;David Montefiori

Frequent Co-Authors

Dani P. Bolognesi
Dani P. Bolognesi Duke University
Guido Ferrari
Guido Ferrari Duke University
Barton F. Haynes
Barton F. Haynes Duke University
Georgia D. Tomaras
Georgia D. Tomaras Duke University
Michael C. Keefer
Michael C. Keefer University of Rochester
M. Juliana McElrath
M. Juliana McElrath University of Washington
David C. Montefiori
David C. Montefiori Duke University
John Bartlett
John Bartlett Duke University
Barney S. Graham
Barney S. Graham Morehouse School of Medicine
Thomas J. Matthews
Thomas J. Matthews University of Birmingham

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