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Immunology

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9621
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National Ranking
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Overview

Michael C. Keefer is affiliated with the University of Rochester in the United States. Their research primarily focuses on immunology, microbiology, and medicine, with substantial contributions to the fields of virology, immunology, infectious diseases, molecular biology, and epidemiology.

The scientist's work covers multiple main topics, including:

  • HIV Research and Treatment
  • Immune Cell Function and Interaction
  • Vaccines and Immunoinformatics Approaches
  • T-cell and B-cell Immunology
  • HIV/AIDS Drug Development and Treatment
  • HIV/AIDS Research and Interventions
  • Hepatitis C Virus Research

Michael C. Keefer has published numerous papers in reputable venues. Frequent publication sources include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • The Journal of Infectious Diseases
  • The Lancet HIV
  • JCI Insight
  • Cell Reports Medicine

Recent papers authored or co-authored by Keefer span important topics related to infectious diseases and vaccine development. Notable recent publications are:

  • Safety and immunogenicity of SARS-CoV-2 recombinant protein vaccine formulations in healthy adults: interim results of a randomised, placebo-controlled, phase 1-2, dose-ranging study (2021) in The Lancet Infectious Diseases
  • Safety and immunogenicity of two heterologous HIV vaccine regimens in healthy, HIV-uninfected adults (TRAVERSE): a randomised, parallel-group, placebo-controlled, double-blind, phase 1/2a study (2020) in The Lancet HIV
  • Time to Viral Rebound After Interruption of Modern Antiretroviral Therapies (2021) in Clinical Infectious Diseases
  • Assessment of Coronary Artery Disease With Computed Tomography Angiography and Inflammatory and Immune Activation Biomarkers Among Adults With HIV Eligible for Primary Cardiovascular Prevention (2021) in JAMA Network Open
  • Robust antibody and cellular responses induced by DNA-only vaccination for HIV (2020) in JCI Insight

The scientist frequently collaborates with other researchers. Their most frequent co-authors include:

  • Georgia D. Tomaras
  • M. Juliana McElrath
  • Lawrence Corey
  • Paul Goepfert
  • Ian Frank

Best Publications

  • Efficacy Trial of a DNA/rAd5 HIV-1 Preventive Vaccine

    Scott M. Hammer;Magdalena E. Sobieszczyk;Holly Janes;Shelly T. Karuna

  • Immunization with Envelope Subunit Vaccine Products Elicits Neutralizing Antibodies against Laboratory-Adapted but Not Primary Isolates of Human Immunodeficiency Virus Type 1

    J R Mascola;S W Snyder;O S Weislow;S M Belay

  • Phase 3 Safety and Efficacy of AZD1222 (ChAdOx1 nCoV-19) Covid-19 Vaccine.

    Ann R Falsey;Magdalena E Sobieszczyk;Ian Hirsch;Stephanie Sproule

  • Immune Responses to Human Immunodeficiency Virus (HIV) Type 1 Induced by Canarypox Expressing HIV-1MN gp120, HIV-1SF2 Recombinant gp120, or Both Vaccines in Seronegative Adults

    Mary Lou Clements-Mann;Kent Weinhold;Thomas J. Matthews;Barney S. Graham

  • A Canarypox Vaccine Expressing Multiple Human Immunodeficiency Virus Type 1 Genes Given Alone or with Rgp120 Elicits Broad and Durable CD8+ Cytotoxic T Lymphocyte Responses in Seronegative Volunteers

    Thomas G. Evans;Michael C. Keefer;Kent J. Weinhold;Mark Wolff

  • Safety and Comparative Immunogenicity of an HIV-1 DNA Vaccine in Combination with Plasmid Interleukin 12 and Impact of Intramuscular Electroporation for Delivery

    Spyros A. Kalams;Scott D. Parker;Marnie Elizaga;Barbara Metch

  • Induction of immune responses to HIV-1 by canarypox virus (ALVAC) HIV-1 and gp120 SF-2 recombinant vaccines in uninfected volunteers. NIAID AIDS Vaccine Evaluation Group.

    Robert B. Belshe;Geoffrey J. Gorse;Mark J. Mulligan;Thomas G. Evans

  • Augmentation of Human Immunodeficiency Virus Type 1 Neutralizing Antibody by Priming with gp160 Recombinant Vaccinia and Boosting with gp160 in Vaccinia-Naive Adults

    Barney S. Graham;Thomas J. Matthews;Robert B. Belshe;Mary Lou Clements

  • Diversion of HIV-1 vaccine–induced immunity by gp41-microbiota cross-reactive antibodies

    Wilton B. Williams;Hua Xin Liao;M. Anthony Moody;Thomas B. Kepler

  • Safety and immunogenicity of a canarypox-vectored human immunodeficiency virus Type 1 vaccine with or without gp120: a phase 2 study in higher- and lower-risk volunteers.

    Robert B. Belshe;Cladd Stevens;Geoffrey J. Gorse;Susan Buchbinder

  • Vaccination of vaccinia-naive adults with human immunodeficiency virus type 1 gp160 recombinant vaccinia virus in a blinded, controlled, randomized clinical trial. The AIDS Vaccine Clinical Trials Network.

    Graham Bs;Belshe Rb;Clements Ml;Dolin R

  • A Phase IIA Randomized Clinical Trial of a Multiclade HIV-1 DNA Prime Followed by a Multiclade rAd5 HIV-1 Vaccine Boost in Healthy Adults (HVTN204)

    Gavin J. Churchyard;Cecilia Morgan;Elizabeth Adams;John Hural

  • QS-21 promotes an adjuvant effect allowing for reduced antigen dose during HIV-1 envelope subunit immmunization in humans

    Thomas G. Evans;M.Juliana McElrath;Tom Matthews;David Montefiori

  • The Emperor's New Clothes: PRospective Observational Evaluation of the Association Between Initial VancomycIn Exposure and Failure Rates Among ADult HospitalizEd Patients With Methicillin-resistant Staphylococcus aureus Bloodstream Infections (PROVIDE).

    Thomas P Lodise;Susan L Rosenkranz;Matthew Finnemeyer;Scott Evans

  • Phase 2 Study of an HIV-1 Canarypox Vaccine (vCP1452) Alone and in Combination With rgp120: Negative Results Fail to Trigger a Phase 3 Correlates Trial

    Nina D. Russell;Nina D. Russell;Nina D. Russell;Barney S. Graham;Michael C. Keefer;M. Juliana McElrath;M. Juliana McElrath

  • Neutralizing Antibodies to HIV-1 in Seronegative Volunteers Immunized With Recombinant gp 120 From the MN Strain of HIV-1

    Robert B. Belshe;Barney S. Graham;Michael C. Keefer;Geoffrey J. Gorse

  • Safety and immunogenicity of a high-titered canarypox vaccine in combination with rgp120 in a diverse population of HIV-1-uninfected adults: AIDS Vaccine Evaluation Group Protocol 022A.

    Kalpana Gupta;Michael Hudgens;Lawrence Corey;M. Juliana McElrath

  • Neutralizing antibodies to HIV-1 in seronegative volunteers immunized with recombinant gp120 from the MN strain of HIV-1. NIAID AIDS Vaccine Clinical Trials Network.

    Belshe Rb;Graham Bs;Keefer Mc;Gorse Gj

  • Safety and Immunogenicity of a Fully Glycosylated Recombinant gp160 Human Immunodeficiency Virus Type 1 Vaccine in Subjects at Low Risk of Infection

    Robert B. Belshe;Mary Lou Clements;Raphael Dolin;Barney S. Graham

  • High Titer HIV-1 V3-Specific Antibodies with Broad Reactivity but Low Neutralizing Potency in Acute Infection and Following Vaccination

    Katie L. Davis;Elin S. Gray;Penny L. Moore;Julie M. Decker

Frequent Co-Authors

Barney S. Graham
Barney S. Graham Morehouse School of Medicine
M. Juliana McElrath
M. Juliana McElrath University of Washington
David C. Montefiori
David C. Montefiori Duke University
Lawrence Corey
Lawrence Corey Fred Hutchinson Cancer Research Center
Georgia D. Tomaras
Georgia D. Tomaras Duke University
Kent J. Weinhold
Kent J. Weinhold Duke University
Raphael Dolin
Raphael Dolin Beth Israel Deaconess Medical Center
Robert B. Belshe
Robert B. Belshe Saint Louis University
Peter B. Gilbert
Peter B. Gilbert Fred Hutchinson Cancer Research Center
Lindsey R. Baden
Lindsey R. Baden Brigham and Women's Hospital

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