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Chemistry

D-Index
50
Citations
8154
World Ranking
14479
National Ranking
2249

Overview

Hequan Yao is affiliated with China Pharmaceutical University in China and primarily works in the field of Chemistry. Their research focuses heavily on Organic Chemistry, with additional contributions in Molecular Biology, Materials Chemistry, Pharmacology, and Inorganic Chemistry.

The main topics of Hequan Yao's work include catalytic C-H functionalization methods, asymmetric synthesis and catalysis, asymmetric hydrogenation and catalysis, computational drug discovery methods, crystallization and solubility studies, X-ray diffraction in crystallography, and catalytic alkyne reactions.

Frequent venues for their research publications are:

  • Organic Letters
  • The Cambridge Structural Database
  • Angewandte Chemie International Edition
  • Angewandte Chemie
  • Nature Communications

Key recent papers authored under Hequan Yao's name include:

  • Ligand-Controlled, Palladium-Catalyzed Asymmetric [4+4] and [2+4] Cycloadditions, 2021, Organic Letters
  • Constructing chiral bicyclo[3.2.1]octanes via palladium-catalyzed asymmetric tandem Heck/carbonylation desymmetrization of cyclopentenes, 2020, Nature Communications
  • Palladium-Catalyzed Asymmetric Sequential Hydroamination of 1,3-Enynes: Enantioselective Syntheses of Chiral Imidazolidinones, 2022, Journal of the American Chemical Society
  • Chemical space exploration based on recurrent neural networks: applications in discovering kinase inhibitors, 2020, Journal of Cheminformatics
  • Identification of a Potent Oridonin Analogue for Treatment of Triple-Negative Breast Cancer, 2020, Journal of Medicinal Chemistry

Hequan Yao collaborates regularly with several researchers, including:

  • Aijun Lin
  • Qiuyu Li
  • Xuanyi Li
  • Kejiang Lin
  • Shang Gao

Their research outputs demonstrate a focus on several specialized areas within organic and medicinal chemistry and employ advanced catalytic processes. The integration of computational drug discovery approaches also marks a multidisciplinary aspect of their work.

Best Publications

  • Fluorescence imaging in vivo: recent advances.

    Jianghong Rao;Anca Dragulescu-Andrasi;Hequan Yao

  • Quantum Dot/Bioluminescence Resonance Energy Transfer Based Highly Sensitive Detection of Proteases†

    Hequan Yao;Yan Zhang;Yan Zhang;Fei Xiao;Zuyong Xia

  • HaloTag protein-mediated site-specific conjugation of bioluminescent proteins to quantum dots.

    Yan Zhang;Min-kyung So;Andreas M. Loening;Hequan Yao

  • Imaging tuberculosis with endogenous β-lactamase reporter enzyme fluorescence in live mice

    Ying Kong;Hequan Yao;Hongjun Ren;Selvakumar Subbian;Selvakumar Subbian

  • Organocatalyzed Asymmetric 1,6-Conjugate Addition of para-Quinone Methides with Dicyanoolefins.

    Xuanyi Li;Xiuyan Xu;Weiwei Wei;Aijun Lin

  • Bifunctional Organo/Metal Cooperatively Catalyzed [3 + 2] Annulation of para-Quinone Methides with Vinylcyclopropanes: Approach to Spiro[4.5]deca-6,9-diene-8-ones.

    Zhenbo Yuan;Weiwei Wei;Aijun Lin;Hequan Yao

  • 1,6-Conjugated Addition-Mediated [2+1] Annulation: Approach to Spiro[2.5]octa-4,7-dien-6-one.

    Zhenbo Yuan;Xinxin Fang;Xuanyi Li;Jie Wu

  • Insights into drug discovery from natural products through structural modification.

    Jichao Chen;Wenlong Li;Hequan Yao;Jinyi Xu

  • Efficient Construction of Fused Indolines with a 2-Quaternary Center via an Intramolecular Heck Reaction with a Low Catalyst Loading

    Lei Zhao;Ziyuan Li;Lin Chang;Jinyi Xu

  • Synthesis of spiro[2.5]octa-4,7-dien-6-one with consecutive quaternary centers via 1,6-conjugate addition induced dearomatization of para-quinone methides

    Kuo Gai;Xinxin Fang;Xuanyi Li;Jinyi Xu

  • Controllable Rh(III)-Catalyzed Annulation between Salicylaldehydes and Diazo Compounds: Divergent Synthesis of Chromones and Benzofurans.

    Peng Sun;Shang Gao;Chi Yang;Songjin Guo

  • Rh(III)-Catalyzed Redox-Neutral Annulation of Primary Benzamides with Diazo Compounds: Approach to Isoquinolinones

    Youzhi Wu;Peng Sun;Kaifan Zhang;Tie Yang

  • 1,6‐Addition Arylation of para‐Quinone Methides: An Approach to Unsymmetrical Triarylmethanes

    Shang Gao;Xiuyan Xu;Zhenbo Yuan;Haipin Zhou

  • A Bioluminogenic Substrate for In Vivo Imaging of β‐Lactamase Activity

    Hequan Yao;Min-kyung So;Jianghong Rao

  • Discovery of Novel Quinoline–Chalcone Derivatives as Potent Antitumor Agents with Microtubule Polymerization Inhibitory Activity

    Wenlong Li;Feijie Xu;Wen Shuai;Honghao Sun

  • Solvent-Controlled Switchable C–H Alkenylation of 4-Aryl-1H-pyrrole-3-carboxylates: Application to the Total Synthesis of (±)-Rhazinilam

    Youla Su;Haipin Zhou;Jiaxuan Chen;Jinyi Xu

  • 1,6-Conjugated addition-mediated [4 + 1] annulation: an approach to 2,3-dihydrobenzofurans

    Lina Liu;Zhenbo Yuan;Rui Pan;Yuye Zeng

  • [3 + 3] Cycloaddition of in Situ Formed Azaoxyallyl Cations with 2-Alkenylindoles: An Approach to Tetrahydro-β-carbolinones

    Kaifan Zhang;Xiaoying Xu;Jiuan Zheng;Hequan Yao

  • Discovery of novel hybrids of diaryl-1,2,4-triazoles and caffeic acid as dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase for cancer therapy.

    Hao Cai;Xiaojing Huang;Shengtao Xu;Hao Shen

  • Synthesis and biological evaluation of ticagrelor derivatives as novel antiplatelet agents

    Hao Zhang;Jun Liu;Luyong Zhang;Lingyi Kong

  • A Novel Potent Anticancer Compound Optimized from a Natural Oridonin Scaffold Induces Apoptosis and Cell Cycle Arrest through the Mitochondrial Pathway

    Shengtao Xu;Hong Yao;Shanshan Luo;Yun-Kai Zhang

  • Multiple Roles of the Pyrimidyl Group in the Rhodium-Catalyzed Regioselective Synthesis and Functionalization of Indole-3-carboxylic Acid Esters

    Hui Jiang;Shang Gao;Jinyi Xu;Xiaoming Wu

  • Multifunctional tacrine-flavonoid hybrids with cholinergic, β-amyloid-reducing, and metal chelating properties for the treatment of Alzheimer's disease.

    Su-Yi Li;Xiao-Bing Wang;Sai-Sai Xie;Neng Jiang

  • Cascade Radical 1,6-Addition/Cyclization of para-Quinone Methides: Leading to Spiro[4.5]deca-6,9-dien-8-ones.

    Rui Pan;Lingyin Hu;Chunhua Han;Aijun Lin

  • [3 + 2] Cycloaddition Reaction of in Situ Formed Azaoxyallyl Cations with Aldehydes: An Approach to Oxazolidin-4-ones

    Kaifan Zhang;Chi Yang;Hequan Yao;Aijun Lin

Frequent Co-Authors

Jinyi Xu
Jinyi Xu China Pharmaceutical University
Ling-Yi Kong
Ling-Yi Kong China Pharmaceutical University
Jianghong Rao
Jianghong Rao Stanford University
Zhe-Sheng Chen
Zhe-Sheng Chen St. John's University
Wen-Cai Ye
Wen-Cai Ye Jinan University
Osamu Muraoka
Osamu Muraoka Kindai University
Qinglong Guo
Qinglong Guo China Pharmaceutical University
Jun O. Liu
Jun O. Liu Johns Hopkins University School of Medicine
James C. Sacchettini
James C. Sacchettini Texas A&M University
Sanjiv S. Gambhir
Sanjiv S. Gambhir Stanford University

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