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James C. Sacchettini

James C. Sacchettini

D-Index & Metrics

Biology and Biochemistry

D-Index
120
Citations
48646
World Ranking
648
National Ranking
413

Overview

James C. Sacchettini is affiliated with Texas A&M University in the United States. Their research contributions focus primarily on the fields of medicine and biochemistry, genetics, and molecular biology.

The core subfields of their work include infectious diseases, molecular biology, and epidemiology. These areas reflect an emphasis on understanding disease mechanisms and biological processes at the molecular level.

James C. Sacchettini's main research topics cover tuberculosis research and epidemiology, RNA and protein synthesis mechanisms, and Pneumocystis jirovecii pneumonia detection and treatment. These topics indicate a concentration on infectious disease pathogenesis and therapeutic strategies.

The scientist has published in the following venues:

  • Cell

Their recent publication is titled "Discovery of natural-product-derived sequanamycins as potent oral anti-tuberculosis agents", published in 2023 in the journal Cell. This work has been cited in the academic literature 21 times.

Frequent co-authors collaborating with James C. Sacchettini include:

  • Jidong Zhang
  • Christine Lair
  • Christine Roubert
  • Kwame Amaning
  • María Belén Pascual Barrio

Best Publications

  • PHENIX: building new software for automated crystallographic structure determination

    Paul D Adams;Ralf W Grosse-Kunstleve;Li Wei Hung;Thomas R Ioerger

  • Persistence of Mycobacterium tuberculosis in macrophages and mice requires the glyoxylate shunt enzyme isocitrate lyase

    John D. McKinney;John D. McKinney;John D. McKinney;Kerstin Höner Zu Bentrup;Kerstin Höner Zu Bentrup;Kerstin Höner Zu Bentrup;Ernesto J. Muñoz-Elias;Andras Miczak;Andras Miczak

  • Crystal structure of a plant catechol oxidase containing a dicopper center.

    Thomas Klabunde;Christoph Eicken;James C. Sacchettini;Bernt Krebs

  • Modification of the NADH of the Isoniazid Target (InhA) from Mycobacterium tuberculosis

    Denise A. Rozwarski;Gregory A. Grant;Derek H. R. Barton;William R. Jacobs

  • Creating Isoprenoid Diversity

    James C. Sacchettini;C. Dale Poulter

  • Automated Structure Solution with the PHENIX Suite

    Peter H. Zwart;Pavel V. Afonine;Ralf W. Grosse-Kunstleve;Li-Wei Hung

  • Sterilization of granulomas is common in active and latent tuberculosis despite within-host variability in bacterial killing

    Philana Ling Lin;Christopher B Ford;Christopher B Ford;M Teresa Coleman;Amy J Myers

  • Crystal structure and function of the isoniazid target of Mycobacterium tuberculosis.

    Andrea Dessen;Annaik Quemard;John S. Blanchard;William R. Jacobs

  • Crystal structure of recombinant farnesyl diphosphate synthase at 2.6-A resolution.

    L.C Tarshis;M Yan;C.D Poulter;J.C. Sacchettini

  • Use of whole genome sequencing to estimate the mutation rate of Mycobacterium tuberculosis during latent infection

    Christopher B Ford;Philana Ling Lin;Michael R Chase;Rupal R Shah

  • Enzymatic characterization of the target for isoniazid in Mycobacterium tuberculosis.

    Annaiek Quemard;James C. Sacchettini;Andrea Dessen;Catherine Vilcheze

  • Crystal structure of rat intestinal fatty-acid-binding protein. Refinement and analysis of the Escherichia coli-derived protein with bound palmitate.

    James C. Sacchettini;Jeffrey I. Gordon;Leonard J. Banaszak

  • An amino acid substitution in the human intestinal fatty acid binding protein is associated with increased fatty acid binding, increased fat oxidation, and insulin resistance.

    L J Baier;J C Sacchettini;W C Knowler;J Eads

  • Rational design of potent human transthyretin amyloid disease inhibitors.

    T. Klabunde;H.M. Petrassi;V.B. Oza;P. Raman

  • Regulation of product chain length by isoprenyl diphosphate synthases.

    L.C Tarshis;P.J Proteau;B.A Kellogg;J.C Sacchettini

  • Recent developments in the PHENIX software for automated crystallographic structure determination

    Paul D. Adams;Kreshna Gopal;Ralf W. Grosse-Kunstleve;Li-Wei Hung

  • Multivalent protein-carbohydrate interactions. A new paradigm for supermolecular assembly and signal transduction.

    J C Sacchettini;L G Baum;C F Brewer

  • Crystal structure of the major histocompatibility complex class I H-2Kb molecule containing a single viral peptide: implications for peptide binding and T-cell receptor recognition.

    Weiguo Zhang;Aideen C. M. Young;Monica Imarai;Stanley G. Nathenson

  • Transfer of a point mutation in Mycobacterium tuberculosis inhA resolves the target of isoniazid.

    Catherine Vilchèze;Feng Wang;Masayoshi Arai;Manzour Hernando Hazbón

  • Therapeutic strategies for human amyloid diseases

    James C. Sacchettini;Jeffery W. Kelly

Frequent Co-Authors

Thomas R. Ioerger
Thomas R. Ioerger Texas A&M University
William R. Jacobs
William R. Jacobs Albert Einstein College of Medicine
Eric J. Rubin
Eric J. Rubin Harvard University
Tanya Parish
Tanya Parish Seattle Children's Hospital
Jeffrey I. Gordon
Jeffrey I. Gordon Washington University in St. Louis
Catherine Vilchèze
Catherine Vilchèze Albert Einstein College of Medicine
Laurent Kremer
Laurent Kremer Institut de Recherche en Infectiologie de Montpellier
Giovanna Scapin
Giovanna Scapin MSD (United States)
Kyu Y. Rhee
Kyu Y. Rhee Cornell University
Gurdyal S. Besra
Gurdyal S. Besra University of Birmingham

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