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Biology and Biochemistry

D-Index
59
Citations
10094
World Ranking
12781
National Ranking
5449

Overview

Kyu Y. Rhee is affiliated with Cornell University in the United States and has made contributions primarily in the fields of medicine and biochemistry, genetics, and molecular biology.

Their research focuses extensively on molecular biology, infectious diseases, epidemiology, public health, environmental and occupational health, and molecular medicine. Key topics within their work include tuberculosis research and epidemiology, Mycobacterium research and diagnosis, biochemical and molecular research, antibiotic resistance in bacteria, bacterial genetics and biotechnology, bacteriophages and microbial interactions, and enzyme structure and function.

Rhee's frequent co-authors include Dirk Schnappinger, Adrián Jinich, Sabine Ehrt, Vijay Soni, and Robert S. Jansen. This indicates ongoing collaborations within microbial and infectious disease research domains.

The scientist has published extensively in several venues, with the highest number of publications appearing in bioRxiv (Cold Spring Harbor Laboratory). Other notable publication venues include Nature Communications, mBio, JCI Insight, and the Proceedings of the National Academy of Sciences.

Among the recent papers by Kyu Y. Rhee are the following:

  • Engineering tumor-colonizing E. coli Nissle 1917 for detection and treatment of colorectal neoplasia, 2024, Nature Communications
  • Dietary fructose improves intestinal cell survival and nutrient absorption, 2021, Nature
  • Growth of Mycobacterium tuberculosis at acidic pH depends on lipid assimilation and is accompanied by reduced GAPDH activity, 2021, Proceedings of the National Academy of Sciences
  • The membrane protein ANKH is crucial for bone mechanical performance by mediating cellular export of citrate and ATP, 2020, PLoS Genetics
  • Dissociation of Adaptive Thermogenesis from Glucose Homeostasis in Microbiome-Deficient Mice, 2020, Cell Metabolism

Best Publications

  • Gluconeogenic carbon flow of tricarboxylic acid cycle intermediates is critical for Mycobacterium tuberculosis to establish and maintain infection

    Joeli Marrero;Kyu Y. Rhee;Dirk Schnappinger;Kevin Pethe

  • Metabolomics of Mycobacterium tuberculosis Reveals Compartmentalized Co-Catabolism of Carbon Substrates

    Luiz Pedro S. de Carvalho;Steven M. Fischer;Joeli Marrero;Carl Nathan

  • A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy

    Kevin Pethe;Patricia C. Sequeira;Sanjay Agarwalla;Kyu Rhee

  • Metabolic principles of persistence and pathogenicity in Mycobacterium tuberculosis

    Sabine Ehrt;Dirk Schnappinger;Kyu Y. Rhee

  • High-fructose corn syrup enhances intestinal tumor growth in mice.

    Marcus D. Goncalves;Changyuan Lu;Jordan Tutnauer;Travis E. Hartman

  • Multifunctional essentiality of succinate metabolism in adaptation to hypoxia in Mycobacterium tuberculosis

    Hyungjin Eoh;Kyu Y. Rhee

  • Isocitrate lyase mediates broad antibiotic tolerance in Mycobacterium tuberculosis

    Madhumitha Nandakumar;Carl Nathan;Kyu Y. Rhee

  • Para-Aminosalicylic Acid Acts as an Alternative Substrate of Folate Metabolism in Mycobacterium tuberculosis

    Sumit Chakraborty;Todd Gruber;Clifton E. Barry;Helena I. Boshoff

  • Selective killing of nonreplicating mycobacteria.

    Ruslana Bryk;Benjamin Gold;Aditya Venugopal;Jasbir Singh

  • Depletion of antibiotic targets has widely varying effects on growth

    Jun-Rong Wei;Vidhya Krishnamoorthy;Kenan Murphy;Jee-Hyun Kim

  • S-nitroso proteome of Mycobacterium tuberculosis: Enzymes of intermediary metabolism and antioxidant defense.

    Kyu Y. Rhee;Hediye Erdjument-Bromage;Paul Tempst;Carl F. Nathan

  • Central carbon metabolism in Mycobacterium tuberculosis: an unexpected frontier

    Kyu Y. Rhee;Luiz Pedro Sorio de Carvalho;Ruslana Bryk;Sabine Ehrt

  • Dietary fructose improves intestinal cell survival and nutrient absorption

    Samuel R Taylor;Shakti Ramsamooj;Roger J Liang;Alyna Katti

  • Methylcitrate cycle defines the bactericidal essentiality of isocitrate lyase for survival of Mycobacterium tuberculosis on fatty acids

    Hyungjin Eoh;Kyu Y. Rhee

  • Ergothioneine Maintains Redox and Bioenergetic Homeostasis Essential for Drug Susceptibility and Virulence of Mycobacterium tuberculosis

    Vikram Saini;Bridgette M. Cumming;Loni Guidry;Dirk A. Lamprecht

  • Evaluating the sensitivity of Mycobacterium tuberculosis to biotin deprivation using regulated gene expression.

    Sae Woong Park;Marcus Klotzsche;Daniel J. Wilson;Helena I. Boshoff

  • A genetic strategy to identify targets for the development of drugs that prevent bacterial persistence

    Jee Hyun Kim;Kathryn M. O'Brien;Ritu Sharma;Helena I.M. Boshoff

  • Virulence of Mycobacterium tuberculosis Depends on Lipoamide Dehydrogenase, a Member of Three Multienzyme Complexes

    Aditya Venugopal;Ruslana Bryk;Shuangping Shi;Kyu Rhee

  • Nitazoxanide Disrupts Membrane Potential and Intrabacterial pH Homeostasis of Mycobacterium tuberculosis

    Luiz Pedro S. de Carvalho;Crystal M. Darby;Kyu Y. Rhee;Carl Nathan

  • Glucose phosphorylation is required for Mycobacterium tuberculosis persistence in mice.

    Joeli Marrero;Carolina Trujillo;Kyu Y. Rhee;Sabine Ehrt

Frequent Co-Authors

Sabine Ehrt
Sabine Ehrt Cornell University
Dirk Schnappinger
Dirk Schnappinger Cornell University
Clifton E. Barry
Clifton E. Barry National Institute of Allergy and Infectious Diseases
Carl Nathan
Carl Nathan Cornell University
James C. Sacchettini
James C. Sacchettini Texas A&M University
Helena I. Boshoff
Helena I. Boshoff National Institutes of Health
Thomas R. Ioerger
Thomas R. Ioerger Texas A&M University
Véronique Dartois
Véronique Dartois Rutgers, The State University of New Jersey
Lisa Saiman
Lisa Saiman Columbia University
Eric J. Rubin
Eric J. Rubin Harvard University

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