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Biology and Biochemistry

D-Index
60
Citations
24864
World Ranking
11676
National Ranking
5023

Overview

Deborah T. Hung is affiliated with the Broad Institute in the United States. Their research spans several areas within biochemistry, genetics, molecular biology, and medicine. Hung has contributed extensively to the fields of molecular biology and infectious diseases, with particular focus on molecular medicine and genetics.

The scientist's work extensively covers key topics such as antibiotic resistance in bacteria, SARS-CoV-2 and COVID-19 research, and detection and testing related to SARS-CoV-2. Additional areas of specialization include tuberculosis research and epidemiology, CRISPR and genetic engineering, bacterial genetics and biotechnology, as well as Mycobacterium research and diagnosis.

Frequently collaborating with other researchers, Deborah T. Hung has significant coauthorship connections with Lisa A. Cosimi, James Gomez, Roby P. Bhattacharyya, Peijun Ma, and Paul C. Blainey. These frequent collaborations indicate a broad and interdisciplinary research network.

Their publications appear in a range of venues, with a marked presence in bioRxiv (Cold Spring Harbor Laboratory) with 29 publications, followed by Nature Medicine and ACS Infectious Diseases, each with 5 publications. Additional frequent venues include Nature Communications with 4 publications and the Proceedings of the National Academy of Sciences with 3 publications.

Representative papers authored or coauthored by Deborah T. Hung include:

  • COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets, 2021, Nature
  • Massively multiplexed nucleic acid detection with Cas13, 2020, Nature
  • Detection of SARS-CoV-2 with SHERLOCK One-Pot Testing, 2020, New England Journal of Medicine
  • An immune-cell signature of bacterial sepsis, 2020, Nature Medicine
  • Multiplexed CRISPR-based microfluidic platform for clinical testing of respiratory viruses and identification of SARS-CoV-2 variants, 2022, Nature Medicine

Best Publications

  • SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues.

    Carly G.K. Ziegler;Samuel J. Allon;Sarah K. Nyquist;Ian M. Mbano

  • Targeting virulence: a new paradigm for antimicrobial therapy

    Anne E Clatworthy;Emily Pierson;Deborah T Hung

  • Definitions and guidelines for research on antibiotic persistence

    Naomi N.Q. Balaban;Sophie Helaine;Kim Lewis;Martin Ackermann;Martin Ackermann

  • HLA-A2-peptide complexes: refolding and crystallization of molecules expressed in Escherichia coli and complexed with single antigenic peptides.

    David N. Garboczi;Deborah T. Hung;Don C. Wiley

  • Detection of SARS-CoV-2 with SHERLOCK One-Pot Testing.

    Julia Joung;Alim Ladha;Makoto Saito;Nam Gyun Kim

  • COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets.

    Toni M. Delorey;Carly G. K. Ziegler;Graham Heimberg;Rachelly Normand

  • Massively multiplexed nucleic acid detection with Cas13.

    Cheri M. Ackerman;Cameron Myhrvold;Cameron Myhrvold;Sri Gowtham Thakku;Sri Gowtham Thakku;Catherine A. Freije;Catherine A. Freije

  • An immune-cell signature of bacterial sepsis

    Miguel Reyes;Michael R. Filbin;Roby P. Bhattacharyya;Kianna Billman

  • Tethered ligand agonist peptides. Structural requirements for thrombin receptor activation reveal mechanism of proteolytic unmasking of agonist function.

    R. M. Scarborough;M. A. Naughton;W. Teng;D. T. Hung

  • Persistent bacterial infections, antibiotic tolerance, and the oxidative stress response

    Sarah Schmidt Grant;Deborah T. Hung

  • Characterization of a functional thrombin receptor. Issues and opportunities.

    S. R. Coughlin;T.-K. H. Vu;D. T. Hung;V. I. Wheaton

  • Identification of the immunophilins capable of mediating inhibition of signal transduction by cyclosporin A and FK506: roles of calcineurin binding and cellular location.

    Richard J. Bram;Deborah T. Hung;Patrick K. Martin;Stuart L. Schreiber

  • The cloned platelet thrombin receptor couples to at least two distinct effectors to stimulate phosphoinositide hydrolysis and inhibit adenylyl cyclase.

    D.T. Hung;Yung Hou Wong;T-Kh Vu;S.R. Coughlin

  • Genomic epidemiology of the Escherichia coli O104:H4 outbreaks in Europe, 2011

    Yonatan H. Grad;Marc Lipsitch;Marc Lipsitch;Michael Feldgarden;Harindra M. Arachchi

  • Eradication of bacterial persisters with antibiotic-generated hydroxyl radicals.

    Sarah Schmidt Grant;Benjamin B. Kaufmann;Nikhilesh S. Chand;Nathan Haseley

  • Pathogen Cell-to-Cell Variability Drives Heterogeneity in Host Immune Responses

    Roi Avraham;Nathan Haseley;Nathan Haseley;Douglas Brown;Cristina Penaranda

  • Identification of Novel Inhibitors of M. tuberculosis Growth Using Whole Cell Based High-Throughput Screening

    Sarah A. Stanley;Sarah Schmidt Grant;Sarah Schmidt Grant;Tomohiko Kawate;Tomohiko Kawate;Noriaki Iwase

  • UNDERSTANDING AND CONTROLLING THE CELL CYCLE WITH NATURAL PRODUCTS

    Deborah T. Hung;Timothy F. Jamison;Stuart L. Schreiber

  • Simultaneous generation of many RNA-seq libraries in a single reaction

    Alexander A Shishkin;Georgia Giannoukos;Alper Kucukural;Dawn Ciulla

  • Cloned platelet thrombin receptor is necessary for thrombin-induced platelet activation.

    D. T. Hung;T.-K. H. Vu;V. I. Wheaton;K. Ishii

Frequent Co-Authors

Jonathan Livny
Jonathan Livny Broad Institute
Eric S. Lander
Eric S. Lander Broad Institute
Stuart L. Schreiber
Stuart L. Schreiber Harvard University
Nir Hacohen
Nir Hacohen Harvard University
Ashlee M. Earl
Ashlee M. Earl Broad Institute
Aviv Regev
Aviv Regev Genentech
Eric J. Rubin
Eric J. Rubin Harvard University
Pardis C. Sabeti
Pardis C. Sabeti Harvard University

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