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D-Index & Metrics

Biology and Biochemistry

D-Index
58
Citations
46313
World Ranking
12864
National Ranking
5474

Overview

Ashlee M. Earl is a researcher affiliated with the Broad Institute in the United States. Their work spans multiple domains within biochemistry, genetics, molecular biology, and medicine, with a particular emphasis on molecular biology and molecular medicine.

They have contributed extensively to the study of antibiotic resistance in bacteria, gut microbiota and health, and genomics and phylogenetic studies. Additional areas of research include bacterial identification and susceptibility testing, Escherichia coli research studies, urinary tract infections management, and antibiotic use and resistance.

Frequent co-authors collaborating with Ashlee M. Earl include:

  • Abigail L. Manson
  • Colin J. Worby
  • Regina C. LaRocque
  • Scott J. Hultgren
  • Thomas Abeel

Their publications appear regularly in several key academic venues. The most commonly featured publication platforms are:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Microbiology
  • Open Forum Infectious Diseases
  • Nature Communications
  • mBio

Notable recent papers authored or co-authored by Ashlee M. Earl include:

  • "Clinically relevant mutations in core metabolic genes confer antibiotic resistance," 2021, Science
  • "Questioning the fetal microbiome illustrates pitfalls of low-biomass microbial studies," 2023, Nature
  • "Discovery of a structural class of antibiotics with explainable deep learning," 2023, Nature
  • "Adaptive evolution of virulence and persistence in carbapenem-resistant Klebsiella pneumoniae," 2020, Nature Medicine
  • "Benchmarking AlphaFold-enabled molecular docking predictions for antibiotic discovery," 2022, Molecular Systems Biology

Within their fields, Ashlee M. Earl's research focuses on infectious diseases and epidemiology alongside the primary disciplines of molecular biology and medicine. Their contributions involve molecular and genomic approaches to understanding pathogen resistance, antibiotic development, and microbial community dynamics.

Best Publications

  • Structure, function and diversity of the healthy human microbiome

    Curtis Huttenhower;Curtis Huttenhower;Dirk Gevers;Rob Knight;Rob Knight;Sahar Abubucker

  • Pilon: An Integrated Tool for Comprehensive Microbial Variant Detection and Genome Assembly Improvement

    Bruce J. Walker;Thomas Abeel;Terrance Shea;Margaret Priest

  • Chimeric 16S rRNA sequence formation and detection in Sanger and 454-pyrosequenced PCR amplicons

    Brian J. Haas;Dirk Gevers;Ashlee M. Earl;Mike Feldgarden

  • A framework for human microbiome research

    Barbara A. Methé;Karen E. Nelson;Mihai Pop;Heather H. Creasy

  • Genomic analysis identifies association of Fusobacterium with colorectal carcinoma

    Aleksandar D. Kostic;Dirk Gevers;Chandra Sekhar Pedamallu;Chandra Sekhar Pedamallu;Monia Michaud

  • Individual intestinal symbionts induce a distinct population of RORγ+ regulatory T cells

    Esen Sefik;Naama Geva-Zatorsky;Sungwhan Oh;Liza Konnikova

  • A Catalog of Reference Genomes from the Human Microbiome

    Karen E. Nelson;George M. Weinstock;Sarah K. Highlander

  • Ecology and genomics of Bacillus subtilis

    Ashlee M. Earl;Richard Losick;Roberto Kolter

  • Relating the metatranscriptome and metagenome of the human gut

    Eric A. Franzosa;Xochitl C. Morgan;Nicola Segata;Levi Waldron

  • Gut microbiota utilize immunoglobulin A for mucosal colonization

    Gregory P. Donaldson;Mark S. Ladinsky;K. B. Yu;Jon G. Sanders

  • Fap2 Mediates Fusobacterium nucleatum Colorectal Adenocarcinoma Enrichment by Binding to Tumor-Expressed Gal-GalNAc.

    Jawad Abed;Johanna E.M. Emgård;Gideon Zamir;Mouhammad Faroja

  • Extensive Diversity of Ionizing-Radiation-Resistant Bacteria Recovered from Sonoran Desert Soil and Description of Nine New Species of the Genus Deinococcus Obtained from a Single Soil Sample

    Fred A. Rainey;Keren Ray;Margarida Ferreira;Bridget Z. Gatz

  • Emergence of Epidemic Multidrug-Resistant Enterococcus faecium from Animal and Commensal Strains

    François Lebreton;François Lebreton;Willem van Schaik;Willem van Schaik;Willem van Schaik;Abigail Manson McGuire Manson McGuire;Paul Godfrey

  • Analysis of Deinococcus radiodurans's Transcriptional Response to Ionizing Radiation and Desiccation Reveals Novel Proteins That Contribute to Extreme Radioresistance

    Masashi Tanaka;Ashlee M. Earl;Heather A. Howell;Mie Jung Park

  • Evaluation of 16s rDNA-based community profiling for human microbiome research

    Doyle V. Ward;Dirk Gevers;Georgia Giannoukos;Ashlee M. Earl

  • Why is Deinococcus radiodurans so resistant to ionizing radiation

    John R. Battista;Ashlee M. Earl;Mie-Jung Park

  • Evolution of Extensively Drug-Resistant Tuberculosis over Four Decades: Whole Genome Sequencing and Dating Analysis of Mycobacterium tuberculosis Isolates from KwaZulu-Natal

    Keira A. Cohen;Thomas Abeel;Abigail Manson McGuire;Christopher A. Desjardins

  • Genomic analysis of globally diverse Mycobacterium tuberculosis strains provides insights into the emergence and spread of multidrug resistance

    Abigail L. Manson;Keira A. Cohen;Keira A. Cohen;Thomas Abeel;Thomas Abeel;Christopher A. Desjardins

  • Efficient and robust RNA-seq process for cultured bacteria and complex community transcriptomes

    Georgia Giannoukos;Dawn M Ciulla;Katherine Huang;Brian J Haas

  • Extensive Diversity of Ionizing-Radiation-Resistant Bacteria Recovered from Sonoran Desert Soil and Description of Nine New Species of the Genus Deinococcus Obtained from a Single Soil Sample. [Erratum: 2005 Nov., v. 71, no. 11, p. 7630.]

    Fred A. Rainey;Keren Ray;Margarida Ferreira;Bridget Z. Gatz

Frequent Co-Authors

Bruce W. Birren
Bruce W. Birren Broad Institute
Michael S. Gilmore
Michael S. Gilmore Harvard Medical School
Dirk Gevers
Dirk Gevers Johnson & Johnson (United States)
Sarah Young
Sarah Young University of North Georgia
Qiandong Zeng
Qiandong Zeng LabCorp (United States)
Deborah T. Hung
Deborah T. Hung Harvard University
Jennifer R. Wortman
Jennifer R. Wortman Broad Institute
Brian J. Haas
Brian J. Haas Broad Institute
Curtis Huttenhower
Curtis Huttenhower Harvard University
Karen E. Nelson
Karen E. Nelson J. Craig Venter Institute

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