Shaun R. Coughlin mainly investigates Thrombin, Cell biology, Biochemistry, Receptor and Platelet. The various areas that he examines in his Thrombin study include Platelet activation, Signal transduction and Proteases. His study focuses on the intersection of Biochemistry and fields such as Biophysics with connections in the field of Binding site and Protein structure.
His Receptor study incorporates themes from Gene expression, Cell type and Pharmacology. The Platelet study combines topics in areas such as Bone marrow and Cathepsin G. His work deals with themes such as Endocrinology, Coagulation factor II receptor and Thrombomodulin, which intersect with Protease-activated receptor.
Shaun R. Coughlin mainly focuses on Receptor, Thrombin, Cell biology, Platelet and Thrombin receptor. His study in Receptor is interdisciplinary in nature, drawing from both Molecular biology, Protease-Activated Receptor 1 and Signal transduction. His Thrombin research incorporates themes from Platelet activation and Biochemistry.
His Cell biology research also works with subjects such as
His primary areas of study are Cell biology, Immunology, Receptor, Platelet and Thrombin. His Cell biology study combines topics from a wide range of disciplines, such as Protease, Green fluorescent protein, Zebrafish, Endothelium and In vivo. His research in the fields of G protein-coupled receptor overlaps with other disciplines such as S1PR1.
His research in Platelet is mostly focused on Platelet activation. His primary area of study in Thrombin is in the field of Thrombin receptor. His research integrates issues of Collagen receptor, Protease-activated receptor and GPVI, Platelet membrane glycoprotein in his study of Thrombin receptor.
Shaun R. Coughlin mostly deals with Immunology, Cell biology, G protein-coupled receptor, Platelet and Endothelium. Shaun R. Coughlin interconnects Thrombosis, Microcirculation and Stem cell in the investigation of issues within Immunology. Signal transduction and Receptor are the focus of his G protein-coupled receptor studies.
His Receptor research is multidisciplinary, incorporating elements of Transcriptome and Insulin. His study of Thrombin is a part of Platelet. His Thrombin receptor study in the realm of Thrombin connects with subjects such as Single-nucleotide polymorphism.
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Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation.
Thien-Khai H. Vu;David T. Hung;Virginia I. Wheaton;Shaun R. Coughlin.
Thrombin signalling and protease-activated receptors
Shaun R. Coughlin.
Protease-activated receptors in hemostasis, thrombosis and vascular biology.
S. R. Coughlin.
Journal of Thrombosis and Haemostasis (2005)
A dual thrombin receptor system for platelet activation
Mark L. Kahn;Yao-Wu Zheng;Wei Huang;Violeta Bigornia.
Monocyte chemoattractant protein-1 in human atheromatous plaques.
N A Nelken;S R Coughlin;D Gordon;J N Wilcox.
Journal of Clinical Investigation (1991)
Molecular cloning and functional expression of two monocyte chemoattractant protein 1 receptors reveals alternative splicing of the carboxyl-terminal tails.
Israel F. Charo;Scott J. Myers;Ann Herman;Christian Franci.
Proceedings of the National Academy of Sciences of the United States of America (1994)
Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin
Mark L. Kahn;Mayumi Nakanishi-Matsui;Michael J. Shapiro;Hiroaki Ishihara.
Journal of Clinical Investigation (1999)
Protease-activated receptor 3 is a second thrombin receptor in humans.
Hiroaki Ishihara;Andrew J. Connolly;Dewan Zeng;Mark L. Kahn.
Promotion of Lymphocyte Egress into Blood and Lymph by Distinct Sources of Sphingosine-1-Phosphate
Rajita Pappu;Susan R. Schwab;Ivo Cornelissen;João P. Pereira.
Tissue factor- and factor X-dependent activation of protease-activated receptor 2 by factor VIIa.
Eric Camerer;Wei Huang;Shaun R. Coughlin.
Proceedings of the National Academy of Sciences of the United States of America (2000)
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