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Immunology

D-Index
73
Citations
31174
World Ranking
2083
National Ranking
1020

Overview

Ivan J. Fuss is affiliated with the National Institute of Allergy and Infectious Diseases in the United States. Their research primarily spans the fields of medicine and immunology and microbiology, with significant contributions to immunology, surgery, molecular biology, infectious diseases, and genetics. Fuss's work broadly addresses topics in immunodeficiency and autoimmune disorders, inflammasome and immune disorders, complement system in diseases, renal diseases and glomerulopathies, parvovirus B19 infection studies, immune cell function and interaction, and blood disorders and treatments.

Their recent publications demonstrate a focus on immune mechanisms and clinical immunology. Notable papers include:

  • "Bruton tyrosine kinase deficiency augments NLRP3 inflammasome activation and causes IL-1β-mediated colitis" (2020, Journal of Clinical Investigation)
  • "Robust Antibody and T Cell Responses to SARS-CoV-2 in Patients with Antibody Deficiency" (2021, Journal of Clinical Immunology)
  • "Clinical exome sequencing of 1000 families with complex immune phenotypes: Toward comprehensive genomic evaluations" (2022, Journal of Allergy and Clinical Immunology)
  • "Blau syndrome NOD2 mutations result in loss of NOD2 cross-regulatory function" (2022, Frontiers in Immunology)
  • "BTK drives neutrophil activation for sterilizing antifungal immunity" (2024, Journal of Clinical Investigation)

Fuss frequently publishes in a range of scientific journals, including:

  • The Journal of Immunology
  • Journal of Allergy and Clinical Immunology
  • Journal of Clinical Investigation
  • Frontiers in Immunology
  • Alimentary Pharmacology & Therapeutics

The scientist's collaborative network includes frequent coauthors such as Warren Strober, Jenna Bergerson, Steven M. Holland, Jeffrey I. Cohen, and Alexandra F. Freeman.

Fuss's research integrates clinical and molecular approaches to elucidate immune system dysfunctions and complex immune phenotypes. Their work on inflammasome activation, antibody deficiencies, and immune responses to infection contributes to understanding immune-mediated diseases and potential therapeutic targets.

Best Publications

  • Antibodies to interleukin 12 abrogate established experimental colitis in mice.

    Markus F. Neurath;Ivan Fuss;Brian L. Kelsall;Eckhard Stüber

  • The immunology of mucosal models of inflammation.

    Warren Strober;Ivan J. Fuss;Richard S. Blumberg

  • The fundamental basis of inflammatory bowel disease

    Warren Strober;Ivan Fuss;Peter Mannon

  • Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5.

    I J Fuss;M Neurath;M Neurath;M Boirivant;J S Klein

  • Proinflammatory cytokines in the pathogenesis of inflammatory bowel diseases.

    Warren Strober;Ivan J. Fuss

  • Interleukin-13 Is the Key Effector Th2 Cytokine in Ulcerative Colitis That Affects Epithelial Tight Junctions, Apoptosis, and Cell Restitution

    Frank Heller;Peter Florian;Christian Bojarski;Jan Richter

  • Anti-interleukin-12 antibody for active Crohn's disease

    Peter J. Mannon;Ivan J. Fuss;Lloyd Mayer;Charles O. Elson

  • Cutting edge: regulatory T cells induce CD4+CD25-Foxp3- T cells or are self-induced to become Th17 cells in the absence of exogenous TGF-beta.

    LiLi Xu;Atsushi Kitani;Ivan Fuss;Warren Strober

  • Nonclassical CD1d-restricted NK T cells that produce IL-13 characterize an atypical Th2 response in ulcerative colitis

    Ivan J. Fuss;Frank Heller;Monica Boirivant;Francisco Leon

  • TGF-β1 Plays an Important Role in the Mechanism of CD4+CD25+ Regulatory T Cell Activity in Both Humans and Mice

    Kazuhiko Nakamura;Kazuhiko Nakamura;Atsushi Kitani;Ivan Fuss;Aasta Pedersen

  • Oxazolone colitis, a Th2 colitis model resembling ulcerative colitis, is mediated by IL-13-producing NK-T cells.

    Frank Heller;Ivan J Fuss;Edward E Nieuwenhuis;Edward E Nieuwenhuis;Richard S Blumberg

  • Experimental Models of Inflammatory Bowel Diseases

    Patricia Kiesler;Ivan J. Fuss;Warren Strober

  • Oxazolone Colitis: A Murine Model of T Helper Cell Type 2 Colitis Treatable with Antibodies to Interleukin 4

    Monica Boirivant;Ivan J. Fuss;Alan Chu;Warren Strober

  • Experimental granulomatous colitis in mice is abrogated by induction of TGF-beta-mediated oral tolerance.

    Markus F. Neurath;Ivan Fuss;Brian L. Kelsall;David H. Presky

  • Isolation of whole mononuclear cells from peripheral blood and cord blood.

    Ivan J. Fuss;Marjorie E. Kanof;Phillip D. Smith;Heddy Zola

  • Reciprocal IFN-γ and TGF-β responses regulate the occurrence of mucosal inflammation

    Warren Strober;Brian Kelsall;Ivan Fuss;Thomas Marth

  • PREDOMINANT PATHOGENIC ROLE OF TUMOR NECROSIS FACTOR IN EXPERIMENTAL COLITIS IN MICE

    Markus F. Neurath;Ivan Fuss;Manolis Pasparakis;Lena Alexopoulou

  • A Mutation in the Nlrp3 Gene Causing Inflammasome Hyperactivation Potentiates Th17 Cell-Dominant Immune Responses

    Guangxun Meng;Fuping Zhang;Ivan Fuss;Atsushi Kitani

  • Both IL‐12p70 and IL‐23 are synthesized during active Crohn's disease and are down‐regulated by treatment with anti‐IL‐12 p40 monoclonal antibody

    Ivan J Fuss;Christoph Becker;Zhiqiong Yang;Catherine Groden

  • The Interrelated Roles of TGF-β and IL-10 in the Regulation of Experimental Colitis

    Ivan J. Fuss;Monica Boirivant;Brian Lacy;Warren Strober

Frequent Co-Authors

Warren Strober
Warren Strober National Institute of Allergy and Infectious Diseases
Markus F. Neurath
Markus F. Neurath University of Erlangen-Nuremberg
Brian L. Kelsall
Brian L. Kelsall National Institute of Allergy and Infectious Diseases
Richard S. Blumberg
Richard S. Blumberg Brigham and Women's Hospital
Theo Heller
Theo Heller National Institutes of Health
David E. Kleiner
David E. Kleiner National Institutes of Health
Richard M. Siegel
Richard M. Siegel National Institutes of Health
Masaharu Seno
Masaharu Seno Okayama University
Tsutomu Chiba
Tsutomu Chiba Kyoto University
Claudio Fiocchi
Claudio Fiocchi Cleveland Clinic Lerner College of Medicine

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