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Biology and Biochemistry

D-Index
88
Citations
31818
World Ranking
2674
National Ranking
1390

Overview

Richard M. Siegel is affiliated with the National Institutes of Health in the United States. Their research primarily spans the fields of Medicine and Immunology and Microbiology, with a focus on several subfields including Immunology, Rheumatology, Genetics, Molecular Biology, and Physiology.

The scientist's work investigates topics such as Systemic Lupus Erythematosus Research, Immunodeficiency and Autoimmune Disorders, T-cell and B-cell Immunology, Chronic Lymphocytic Leukemia Research, Dermatological and Skeletal Disorders, Immune Cell Function and Interaction, and Inflammasome and Immune Disorders.

Recent prominent publications by Siegel include:

  • Macrophage metabolic reprogramming presents a therapeutic target in lupus nephritis (2020), Proceedings of the National Academy of Sciences
  • TNF leads to mtDNA release and cGAS/STING-dependent interferon responses that support inflammatory arthritis (2021), Cell Reports
  • Distinct pathogenic roles for resident and monocyte-derived macrophages in lupus nephritis (2022), JCI Insight
  • Somatic SMAD3-activating mutations cause melorheostosis by up-regulating the TGF-β/SMAD pathway (2020), The Journal of Experimental Medicine
  • Efficacy and safety of remibrutinib, a selective potent oral BTK inhibitor, in Sjögren's syndrome: results from a randomised, double-blind, placebo-controlled phase 2 trial (2023), Annals of the Rheumatic Diseases

Siegel frequently collaborates with several researchers, including Mariana J. Kaplan, James D. Katz, Nathan Richoz, Zerai Manna, and Sarfaraz Hasni. These recurring coauthors reflect a pattern of partnerships that contribute to advancing research within immunological and rheumatological domains.

Publications by Siegel are often found in specialized journals focused on rheumatology and immunology. Common publication venues include RMD Open, Proceedings of the National Academy of Sciences, Cell Reports, JCI Insight, and Annals of the Rheumatic Diseases.

Best Publications

  • Interleukin-2 Signaling via STAT5 Constrains T Helper 17 Cell Generation

    Arian Laurence;Cristina M. Tato;Todd S. Davidson;Yuka Kanno

  • Encoding of spatial location by posterior parietal neurons.

    Richard A. Andersen;Gregory K Essick;Ralph M. Siegel

  • Pembrolizumab versus paclitaxel for previously treated, advanced gastric or gastro-oesophageal junction cancer (KEYNOTE-061): a randomised, open-label, controlled, phase 3 trial

    Kohei Shitara;Mustafa Özgüroğlu;Yung-Jue Bang;Maria Di Bartolomeo

  • A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling.

    Francis Ka-Ming Chan;Hyung J. Chun;Lixin Zheng;Richard M. Siegel

  • Mature T lymphocyte apoptosis--immune regulation in a dynamic and unpredictable antigenic environment.

    M Lenardo;K M Chan;F Hornung;H McFarland

  • Corticocortical connections of anatomically and physiologically defined subdivisions within the inferior parietal lobule.

    R. A. Andersen;C. Asanuma;Gregory K Essick;R. M. Siegel

  • Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS)

    Ariel C. Bulua;Anna Simon;Ravikanth Maddipati;Martin Pelletier

  • Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency

    Hyung J. Chun;Lixin Zheng;Manzoor Ahmad;Jin Wang;Jin Wang

  • Fas Preassociation Required for Apoptosis Signaling and Dominant Inhibition by Pathogenic Mutations

    Richard M. Siegel;John K. Frederiksen;David A. Zacharias;Francis Ka Ming Chan

  • Acute Vasoconstrictor Response to Intravenous Furosemide in Patients with Chronic Congestive Heart Failure: Activation of the Neurohumoral Axis

    Gary S Francis;R. M. Siegel;Steven Goldsmith;M. T. Olivari

  • Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease

    Qing Zhou;Hongying Wang;Daniella M. Schwartz;Monique Stoffels

  • The multifaceted role of Fas signaling in immune cell homeostasis and autoimmunity.

    Richard M. Siegel;Francis Ka-Ming Chan;Hyung J. Chun;Michael J. Lenardo

  • Revised diagnostic criteria and classification for the autoimmune lymphoproliferative syndrome (ALPS): report from the 2009 NIH International Workshop.

    Joao B. Oliveira;Jack J. Bleesing;Umberto Dianzani;Thomas A. Fleisher

  • Membrane Oligomerization and Cleavage Activates the Caspase-8 (FLICE/MACHα1) Death Signal

    David A. Martin;Richard M. Siegel;Lixin Zheng;Michael J. Lenardo

  • IL-21 drives expansion and plasma cell differentiation of autoreactive CD11chiT-bet+ B cells in SLE.

    Shu Wang;Jingya Wang;Varsha Kumar;Jodi L Karnell

  • Neurons of area 7 activated by both visual stimuli and oculomotor behavior.

    R. A. Andersen;Gregory K Essick;R. M. Siegel

  • TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis

    Adam P. Gregory;Calliope A. Dendrou;Kathrine E. Attfield;Aiden Haghikia;Aiden Haghikia

  • Selective recognition of acetylated histones by bromodomain proteins visualized in living cells.

    Tomohiko Kanno;Tomohiko Kanno;Yuka Kanno;Richard M Siegel;Moon Kyoo Jang

  • Life And Death Decisions: Secondary Complexes and Lipid Rafts in TNF Receptor Family Signal Transduction

    Jagan R. Muppidi;Jagan R. Muppidi;Jürg Tschopp;Richard M. Siegel

  • Caspases at the crossroads of immune-cell life and death

    Richard M. Siegel

Frequent Co-Authors

Michael J. Lenardo
Michael J. Lenardo National Institute of Allergy and Infectious Diseases
Daniel L. Kastner
Daniel L. Kastner National Institutes of Health
John J. O'Shea
John J. O'Shea National Institutes of Health
Lixin Zheng
Lixin Zheng National Institutes of Health
Mark I. Greene
Mark I. Greene University of Pennsylvania
Christopher A. Klebanoff
Christopher A. Klebanoff Memorial Sloan Kettering Cancer Center
Igal Gery
Igal Gery National Institutes of Health
Joan C. Marini
Joan C. Marini National Institutes of Health
Sharon E. Straus
Sharon E. Straus University of Toronto
Jennifer M. Puck
Jennifer M. Puck University of California, San Francisco

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