World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
48
Citations
12908
World Ranking
18230
National Ranking
99

Overview

Richard A. Engh is affiliated with the University of Tromsø - The Arctic University of Norway. Their research spans multiple fields within biochemistry, genetics, and molecular biology, with a focus on molecular biology as indicated by their publication record.

The scientific contributions of Richard A. Engh cover specific areas including:

  • Protein Kinase Regulation and GTPase Signaling
  • Lipid Membrane Structure and Behavior
  • Computational Drug Discovery Methods
  • Down syndrome and intellectual disability research
  • Thermodynamics and calorimetric analyses
  • Field-Flow Fractionation Techniques
  • Melanoma and MAPK Pathways

Their recent papers reflect a concentration on kinase inhibitors, peptide interactions, and computational drug discovery. Notable publications are:

  • BindingDB Entry 50001791: Novel Scaffolds for Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase (DYRK1A) Inhibitors, 2020, PubMed
  • Novel DYRK1A Inhibitor Rescues Learning and Memory Deficits in a Mouse Model of Down Syndrome, 2021, Pharmaceuticals
  • Label-free measurement of antimicrobial peptide interactions with lipid vesicles and nanodiscs using microscale thermophoresis, 2023, Scientific Reports
  • Drugging the Undruggable: How Isoquinolines and PKA Initiated the Era of Designed Protein Kinase Inhibitor Therapeutics, 2021, Biochemistry
  • Inhibitor binding to mutants of protein kinase A with GGGxxG and GxGxxA glycine-rich loop motifs, 2020, Journal of Molecular Recognition

The frequent coauthors collaborating with Engh include:

  • John S. Svendsen
  • Ulli Rothweiler
  • Philip Rainsford
  • Fredrik G. Rylandsholm
  • Martin Jakubec

The publication venues most associated with Richard A. Engh are:

  • Pharmaceuticals
  • Scientific Reports
  • Biochemistry
  • Journal of Molecular Recognition
  • PubMed

Richard A. Engh's work integrates experimental and computational approaches to explore complex biochemical interactions, with a particular emphasis on kinase regulation and development of inhibitors relevant to diseases such as Down syndrome. Their research contributes to expanding knowledge in molecular behavior, drug discovery, and signaling pathways.

Best Publications

  • Accurate Bond and Angle Parameters for X-ray Protein Structure Refinement

    Richard A. Engh;Robert Huber

  • The 2.0 A X-ray crystal structure of chicken egg white cystatin and its possible mode of interaction with cysteine proteinases.

    W. Bode;R. Engh;D. Musil;U. Thiele

  • The refined 2.15 A X-ray crystal structure of human liver cathepsin B: the structural basis for its specificity.

    D. Musil;D. Zucic;D. Turk;R.A. Engh

  • Crystal Structure of the Xanthine Oxidase-Related Aldehyde Oxido-Reductase from D. gigas

    Maria J. Romão;Margarida Archer;Isabel Moura;José J. G. Moura

  • Phosphotransferase and substrate binding mechanism of the cAMP-dependent protein kinase catalytic subunit from porcine heart as deduced from the 2.0 A structure of the complex with Mn2+ adenylyl imidodiphosphate and inhibitor peptide PKI(5-24).

    D. Bossemeyer;R.A. Engh;V. Kinzel;H. Ponstingl

  • Chalcone derivatives antagonize interactions between the human oncoprotein MDM2 and p53.

    Raphael Stoll;Christian Renner;Silke Hansen;Stefan Palme

  • Crystal Structures of Catalytic Subunit of cAMP-dependent Protein Kinase in Complex with Isoquinolinesulfonyl Protein Kinase Inhibitors H7, H8, and H89 STRUCTURAL IMPLICATIONS FOR SELECTIVITY

    Richard A. Engh;Andreas Girod;Volker Kinzel;Robert Huber

  • X-ray Structure of Active Site-inhibited Clotting Factor Xa IMPLICATIONS FOR DRUG DESIGN AND SUBSTRATE RECOGNITION

    H Brandstetter;A Kühne;W Bode;R Huber

  • Crystal structure of a thermostable type B DNA polymerase from Thermococcus gorgonarius.

    Karl-Peter Hopfner;Andreas Eichinger;Richard A. Engh;Frank Laue

  • Protein Kinase A in Complex with Rho-Kinase Inhibitors Y-27632, Fasudil, and H-1152P: Structural Basis of Selectivity

    Christine Breitenlechner;Michael Gassel;Hiroyoshi Hidaka;Volker Kinzel

  • Staurosporine-induced conformational changes of cAMP-dependent protein kinase catalytic subunit explain inhibitory potential

    Lars Prade;Richard A Engh;Andreas Girod;Volker Kinzel

  • The Interaction of Insulin-Like Growth Factor-I with the N-Terminal Domain of Igfbp-5

    Wojciech Żesławski;Hans-Georg Beisel;Mariusz Kamionka;Wenzel Kalus

  • Lysine 156 promotes the anomalous proenzyme activity of tPA: X-ray crystal structure of single-chain human tPA.

    Martin Renatus;Richard A. Engh;Richard A. Engh;Milton T. Stubbs;Robert Huber

  • Protein kinase inhibition of clinically important staurosporine analogues

    Osman A B S M Gani;Richard A Engh

  • Coagulation factor IXa: the relaxed conformation of Tyr99 blocks substrate binding.

    Karl-Peter Hopfner;Anja Lang;Annette Karcher;Katrin Sichler

  • The 0.25-nm X-ray structure of the Bowman-Birk-type inhibitor from mung bean in ternary complex with porcine trypsin.

    Guangda Lin;Wolfram Bode;Robert Huber;Chengwu Chi

  • The 1.8-Å Crystal Structure of a Matrix Metalloproteinase 8-Barbiturate Inhibitor Complex Reveals a Previously Unobserved Mechanism for Collagenase Substrate Recognition

    Hans Brandstetter;Frank Grams;Dagmar Glitz;Anja Lang

  • Structure-based optimization of novel azepane derivatives as PKB inhibitors

    Christine B. Breitenlechner;Thomas Wegge;Laurent Berillon;Klaus Graul

  • FMS-like tyrosine kinase 3-internal tandem duplication tyrosine kinase inhibitors display a nonoverlapping profile of resistance mutations in vitro.

    Nikolas von Bubnoff;Richard A. Engh;Espen Åberg;Jana Sänger

  • Differential sensitivity of ERBB2 kinase domain mutations towards lapatinib.

    Rama Krishna Kancha;Nikolas von Bubnoff;Natalie Bartosch;Christian Peschel

Frequent Co-Authors

Robert Huber
Robert Huber University of Duisburg-Essen
Wolfram Bode
Wolfram Bode Max Planck Society
Robert Huber
Robert Huber Agricultural & Applied Economics Association
Tad A. Holak
Tad A. Holak Jagiellonian University
Hans Brandstetter
Hans Brandstetter University of Salzburg
Karl-Peter Hopfner
Karl-Peter Hopfner Ludwig-Maximilians-Universität München
Christian Klein
Christian Klein Roche (Switzerland)
Christian Peschel
Christian Peschel Technical University of Munich
Michal Dadlez
Michal Dadlez Polish Academy of Sciences
Werner Machleidt
Werner Machleidt Ludwig-Maximilians-Universität München

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