Hans Brandstetter

Overview

Best Publications

• The crystal structure of dipeptidyl peptidase IV (CD26) reveals its functional regulation and enzymatic mechanism

  Michael Engel;Torsten Hoffmann;Leona Wagner;Michael Wermann

  419
  Citations

• X-ray Structure of Active Site-inhibited Clotting Factor Xa IMPLICATIONS FOR DRUG DESIGN AND SUBSTRATE RECOGNITION

  H Brandstetter;A Kühne;W Bode;R Huber

  359
  Citations

• X-ray structure of clotting factor IXa: active site and module structure related to Xase activity and hemophilia B.

  Hans Brandstetter;Margit Bauer;Robert Huber;Pete Lollar

  345
  Citations

• Molecular Machines for Protein Degradation

  Michael Groll;Matthias Bochtler;Hans Brandstetter;Tim Clausen

  282
  Citations

• Refined 2.3 A X-ray crystal structure of bovine thrombin complexes formed with the benzamidine and arginine-based thrombin inhibitors NAPAP, 4-TAPAP and MQPA. A starting point for improving antithrombotics.

  H. Brandstetter;D. Turk;H.W. Hoeffken;D. Grosse

  275
  Citations

• Structure and function of legumain in health and disease.

  Elfriede Dall;Hans Brandstetter

  249
  Citations

• Crystal structures of the methane monooxygenase hydroxylase from Methylococcus capsulatus (Bath): implications for substrate gating and component interactions.

  Amy C. Rosenzweig;Hans Brandstetter;Hans Brandstetter;Douglas A. Whittington;Pär Nordlund

  229
  Citations

• Mechanistic and Structural Studies on Legumain Explain its Zymogenicity, Distinct Activation Pathways, and Regulation

  Elfriede Dall;Hans Brandstetter

  192
  Citations

• Structural basis of the adaptive molecular recognition by MMP9.

  Hyunju Cha;Erhard Kopetzki;Robert Huber;Martin Lanzendörfer

  182
  Citations

• Natural and synthetic inhibitors of kallikrein-related peptidases (KLKs).

  Peter Goettig;Viktor Magdolen;Hans Brandstetter

  168
  Citations

• Pyrimidine-2,4,6-Triones: a new effective and selective class of matrix metalloproteinase inhibitors.

  Grams F;Brandstetter H;D'Alò S;Geppert D

  157
  Citations

• Coagulation factor IXa: the relaxed conformation of Tyr99 blocks substrate binding.

  Karl-Peter Hopfner;Anja Lang;Annette Karcher;Katrin Sichler

  150
  Citations

• Comparative analysis of haemostatic proteinases : Structural aspects of thrombin, factor Xa, factor IXa and protein C

  Wolfram Bode;Hans Brandstetter;Timothy Mather;Milton T Stubbs

  148
  Citations

• The 1.8-Å Crystal Structure of a Matrix Metalloproteinase 8-Barbiturate Inhibitor Complex Reveals a Previously Unobserved Mechanism for Collagenase Substrate Recognition

  Hans Brandstetter;Frank Grams;Dagmar Glitz;Anja Lang

  147
  Citations

• Changing Residue 338 in Human Factor IX from Arginine to Alanine Causes an Increase in Catalytic Activity

  Jinli Chang;Jianping Jin;Pete Lollar;Wolfram Bode

  139
  Citations

• Structure of collagenase G reveals a chew-and-digest mechanism of bacterial collagenolysis.

  Ulrich Eckhard;Esther Schönauer;Dorota Nüss;Hans Brandstetter

  136
  Citations

• Enzyme flexibility, solvent and 'weak' interactions characterize thrombin-ligand interactions: implications for drug design.

  Richard A Engh;Hans Brandstetter;Gudrun Sucher;Andreas Eichinger

  125
  Citations

• Investigations on the Maturation and Regulation of Archaebacterial Proteasomes

  Michael Groll;Hans Brandstetter;Hans Bartunik;Gleb Bourenkow

  124
  Citations

• Crystal structure of the catalytic domain of human atypical protein kinase C-iota reveals interaction mode of phosphorylation site in turn motif.

  Albrecht Messerschmidt;Sofia Macieira;Milko Velarde;Mathias Bädeker

  124
  Citations

• Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease.

  Zhentao Zhang;Zhentao Zhang;Obiamaka Obianyo;Elfriede Dall;Yuhong Du

  123
  Citations