Milton T. Stubbs

Overview

Best Publications

• The refined 2.4 A X-ray crystal structure of recombinant human stefin B in complex with the cysteine proteinase papain: a novel type of proteinase inhibitor interaction.

  M T Stubbs;B Laber;W Bode;R Huber

  694
  Citations

• A player of many parts : the spotlight falls on thrombin's structure

  Milton T. Stubbs;Milton T. Stubbs;Wolfram Bode;Wolfram Bode

  649
  Citations

• Crystal structure of DhbE, an archetype for aryl acid activating domains of modular nonribosomal peptide synthetases.

  Jürgen J. May;Nadine Kessler;Mohamed A. Marahiel;Milton T. Stubbs

  390
  Citations

• Crystal structures of the membrane-binding C2 domain of human coagulation factor V.

  Sandra Macedo-Ribeiro;Wolfram Bode;Robert Huber;Mary Ann Quinn-Allen

  338
  Citations

• Structural basis for the cyclization of the lipopeptide antibiotic surfactin by the thioesterase domain SrfTE.

  Steven D Bruner;Thomas Weber;Rahul M Kohli;Dirk Schwarzer

  300
  Citations

• The interaction of thrombin with fibrinogen. A structural basis for its specificity.

  Milton T. Stubbs;Hartmut Oschkinat;Irmgard Mayr;Robert Huber

  289
  Citations

• The ornithodorin-thrombin crystal structure, a key to the TAP enigma?

  A. van de Locht;M. T. Stubbs;W. Bode;T. Friedrich

  268
  Citations

• Passing the baton in class B GPCRs: peptide hormone activation via helix induction?

  Christoph Parthier;Steffen Reedtz-Runge;Rainer Rudolph;Milton T. Stubbs

  263
  Citations

• Crystal structure of the incretin-bound extracellular domain of a G protein-coupled receptor

  Christoph Parthier;Martin Kleinschmidt;Piotr Neumann;Rainer Rudolph

  253
  Citations

• Crystal Structure of the Nucleotide-binding Domain of the ABC-transporter Haemolysin B: Identification of a Variable Region Within ABC Helical Domains

  Lutz Schmitt;Houssain Benabdelhak;Mark A. Blight;I.Barry Holland

  248
  Citations

• The clot thickens: clues provided by thrombin structure

  Milton T. Stubbs;Wolfram Bode

  245
  Citations

• Successful virtual screening for novel inhibitors of human carbonic anhydrase: strategy and experimental confirmation.

  Sven Grüneberg;Milton T. Stubbs;Gerhard Klebe

  239
  Citations

• Nonaromatic Sulfonamide Group as an Ideal Anchor for Potent Human Carbonic Anhydrase Inhibitors: Role of Hydrogen-Bonding Networks in Ligand Binding and Drug Design

  Francesco Abbate;Claudiu T. Supuran;Andrea Scozzafava;Pierluigi Orioli

  207
  Citations

• Factorising ligand affinity: a combined thermodynamic and crystallographic study of trypsin and thrombin inhibition.

  F Dullweber;M.T Stubbs;D Musil;J Sturzebecher

  204
  Citations

• Crystal structure of 1-deoxy-D-xylulose-5-phosphate reductoisomerase, a crucial enzyme in the non-mevalonate pathway of isoprenoid biosynthesis.

  Klaus Reuter;Silke Sanderbrand;Hassan Jomaa;Jochen Wiesner

  187
  Citations

• Crystal Structure of DltA IMPLICATIONS FOR THE REACTION MECHANISM OF NON-RIBOSOMAL PEPTIDE SYNTHETASE ADENYLATION DOMAINS

  Huma Yonus;Piotr Neumann;Stephan Zimmermann;Jürgen J. May

  182
  Citations

• Lysine 156 promotes the anomalous proenzyme activity of tPA: X-ray crystal structure of single-chain human tPA.

  Martin Renatus;Richard A. Engh;Richard A. Engh;Milton T. Stubbs;Robert Huber

  164
  Citations

• Structural and functional analyses of benzamidine-based inhibitors in complex with trypsin: implications for the inhibition of factor Xa, tPA, and urokinase.

  Martin Renatus;Wolfram Bode;Robert Huber;Jörg Stürzebecher

  164
  Citations

• Comparative analysis of haemostatic proteinases : Structural aspects of thrombin, factor Xa, factor IXa and protein C

  Wolfram Bode;Hans Brandstetter;Timothy Mather;Milton T Stubbs

  148
  Citations

• Crystal structures of factor Xa specific inhibitors in complex with trypsin: structural grounds for inhibition of factor Xa and selectivity against thrombin.

  Milton T. Stubbs;Robert Huber;Wolfram Bode

  145
  Citations