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62
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8862
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Research.com Recognitions

  • 2009 - Fellow of American Physical Society (APS) Citation For his seminal contributions to the physics of ion channels, thereby bridging molecular biology with physical kinetics and nonlinear dynamics by developing singlemolecular methods to membrane transport and noisefacilitated signal transduction

Overview

Sergey M. Bezrukov is affiliated with the National Institutes of Health in the United States. Their research focuses on biochemistry, genetics, molecular biology, and engineering, with a significant emphasis on molecular biology and biomedical engineering.

The scientist's work extensively covers topics related to mitochondrial function and pathology, nanopore and nanochannel transport studies, lipid membrane structure and behavior, metabolism and genetic disorders, neuroscience and neuropharmacology research, ion channel regulation and function, and electrostatics and colloid interactions.

Bezrukov has published research in several prominent venues, including:

  • Biophysical Journal
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Physical Chemistry Chemical Physics
  • The Journal of Chemical Physics
  • International Journal of Molecular Sciences

Frequent collaborators feature Tatiana K. Rostovtseva, Alexander M. Berezhkovskii, William M. Rosencrans, Megha Rajendran, and David P. Hoogerheide.

Among recent notable publications are:

  • VDAC regulation of mitochondrial calcium flux: From channel biophysics to disease, 2021, Cell Calcium
  • A lower affinity to cytosolic proteins reveals VDAC3 isoform-specific role in mitochondrial biology, 2020, The Journal of General Physiology
  • α-Synuclein emerges as a potent regulator of VDAC-facilitated calcium transport, 2021, Cell Calcium
  • Regulation of Mitochondrial Respiration by VDAC Is Enhanced by Membrane-Bound Inhibitors with Disordered Polyanionic C-Terminal Domains, 2021, International Journal of Molecular Sciences
  • Targeting the Multiple Physiologic Roles of VDAC With Steroids and Hydrophobic Drugs, 2020, Frontiers in Physiology

In 2009, Sergey M. Bezrukov was recognized as a Fellow of the American Physical Society. The citation highlighted their contributions to the physics of ion channels, particularly for bridging molecular biology with physical kinetics and nonlinear dynamics, and for developing single-molecule methods related to membrane transport and noise-facilitated signal transduction.

Best Publications

  • Noise-induced enhancement of signal transduction across voltage-dependent ion channels

    Sergey M. Bezrukov;Igor Vodyanoy;Igor Vodyanoy;Igor Vodyanoy

  • Counting polymers moving through a single ion channel

    Bezrukov Sm;Vodyanoy I;Vodyanoy I;Parsegian Va

  • Designed to penetrate: Time-resolved interaction of single antibiotic molecules with bacterial pores

    Ekaterina M. Nestorovich;Christophe Danelon;Mathias Winterhalter;Sergey M. Bezrukov

  • A voltage-dependent channel involved in nutrient uptake by red blood cells infected with the malaria parasite.

    Sanjay A. Desai;Sergey M. Bezrukov;Joshua Zimmerberg

  • Dynamics and Free Energy of Polymers Partitioning into a Nanoscale Pore

    Sergey M. Bezrukov;Igor Vodyanoy;Rafik A. Brutyan;John J. Kasianowicz

  • Voltage-dependent Anion Channels Modulate Mitochondrial Metabolism in Cancer Cells REGULATION BY FREE TUBULIN AND ERASTIN

    Eduardo N. Maldonado;Kely L. Sheldon;Kely L. Sheldon;David N. DeHart;Jyoti Patnaik

  • Probability of alamethicin conductance states varies with nonlamellar tendency of bilayer phospholipids

    S.L. Keller;S.M. Bezrukov;S.M. Gruner;M.W. Tate

  • Probing alamethicin channels with water-soluble polymers. Effect on conductance of channel states

    S.M. Bezrukov;I. Vodyanoy

  • Bid, but not Bax, regulates VDAC channels.

    Tatiana K. Rostovtseva;Bruno Antonsson;Motoshi Suzuki;Richard J. Youle

  • Protonation dynamics of the alpha-toxin ion channel from spectral analysis of pH-dependent current fluctuations

    J.J. Kasianowicz;S.M. Bezrukov

  • Single polymer molecules in a protein nanopore in the limit of a strong polymer-pore attraction.

    Oleg V. Krasilnikov;Claudio G. Rodrigues;Sergey M. Bezrukov

  • Transport of maltodextrins through maltoporin: a single-channel study.

    Lisen Kullman;Mathias Winterhalter;Sergey M. Bezrukov;Sergey M. Bezrukov

  • Current noise reveals protonation kinetics and number of ionizable sites in an open protein ion channel.

    Sergey M. Bezrukov;John J. Kasianowicz

  • Salting Out the Ionic Selectivity of a Wide Channel: The Asymmetry of OmpF

    Antonio Alcaraz;Ekaterina M. Nestorovich;Marcel Aguilella-Arzo;Vicente M. Aguilella

  • Ion channels as molecular coulter counters to probe metabolite transport.

    Bezrukov Sm

  • Residue ionization and ion transport through OmpF channels.

    Ekaterina M. Nestorovich;Tatiana K. Rostovtseva;Sergey M. Bezrukov

  • Optimizing transport of metabolites through large channels: molecular sieves with and without binding.

    Alexander M. Berezhkovskii;Sergey M. Bezrukov

  • Interaction of Zwitterionic Penicillins with the OmpF Channel Facilitates Their Translocation

    Christophe Danelon;Ekaterina M. Nestorovich;Mathias Winterhalter;Matteo Ceccarelli

  • ATP Transport Through a Single Mitochondrial Channel, VDAC, Studied by Current Fluctuation Analysis

    Tatiana K. Rostovtseva;Sergey M. Bezrukov;Sergey M. Bezrukov

  • Functional consequences of lipid packing stress

    Sergey M Bezrukov;Sergey M Bezrukov

  • On 'three decades of nanopore sequencing'

    John J Kasianowicz;Sergey M Bezrukov

Frequent Co-Authors

Laszlo B. Kish
Laszlo B. Kish Texas A&M University
Sergei Y. Noskov
Sergei Y. Noskov University of Calgary
Mathias Winterhalter
Mathias Winterhalter Jacobs University
Joshua Zimmerberg
Joshua Zimmerberg National Institutes of Health
Claes-Göran Granqvist
Claes-Göran Granqvist Uppsala University
Derek Abbott
Derek Abbott University of Adelaide
John J. Lemasters
John J. Lemasters Medical University of South Carolina
Susan K. Buchanan
Susan K. Buchanan National Institutes of Health
Rudolf Podgornik
Rudolf Podgornik University of Chinese Academy of Sciences
Marco Colombini
Marco Colombini University of Maryland, College Park

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