Hans-Ulrich Demuth

Overview

Best Publications

• Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-β

  Justin M. Nussbaum;Stephan Schilling;Holger Cynis;Antonia Silva

  514
  Citations

• Dipeptidyl Peptidase IV Inhibitor Treatment Stimulates β-Cell Survival and Islet Neogenesis in Streptozotocin-Induced Diabetic Rats

  J. Andrew Pospisilik;Jennifer Martin;Timothy Doty;Jan A. Ehses

  461
  Citations

• The crystal structure of dipeptidyl peptidase IV (CD26) reveals its functional regulation and enzymatic mechanism

  Michael Engel;Torsten Hoffmann;Leona Wagner;Michael Wermann

  419
  Citations

• Glutaminyl cyclase inhibition attenuates pyroglutamate Abeta and Alzheimer's disease-like pathology.

  Stephan Schilling;Ulrike Zeitschel;Torsten Hoffmann;Ulrich Heiser

  404
  Citations

• Long-Term Treatment With the Dipeptidyl Peptidase IV Inhibitor P32/98 Causes Sustained Improvements in Glucose Tolerance, Insulin Sensitivity, Hyperinsulinemia, and β-Cell Glucose Responsiveness in VDF (fa/fa) Zucker Rats

  J. A. Pospisilik;S. G. Stafford;H.-U. Demuth;R. Brownsey

  353
  Citations

• Type 2 diabetes—Therapy with dipeptidyl peptidase IV inhibitors

  Hans-Ulrich Demuth;Christopher H.S. McIntosh;Raymond A. Pederson

  319
  Citations

• On the seeding and oligomerization of pGlu-amyloid peptides (in vitro).

  Stephan Schilling;Thomas Lauber;Michael Schaupp;Susanne Manhart

  308
  Citations

• Crystal structure of the incretin-bound extracellular domain of a G protein-coupled receptor

  Christoph Parthier;Martin Kleinschmidt;Piotr Neumann;Rainer Rudolph

  253
  Citations

• Glucose-Dependent Insulinotropic Polypeptide Promotes β-(INS-1) Cell Survival via Cyclic Adenosine Monophosphate-Mediated Caspase-3 Inhibition and Regulation of p38 Mitogen-Activated Protein Kinase

  Jan A. Ehses;Vanbric R. Casilla;Tim Doty;J. Andrew Pospisilik

  235
  Citations

• Pyroglutamate formation influences solubility and amyloidogenicity of amyloid peptides.

  Dagmar Schlenzig;Susanne Manhart;Yeliz Cinar;Martin Kleinschmidt

  229
  Citations

• The role of dipeptidyl peptidase IV in human T lymphocyte activation. Inhibitors and antibodies against dipeptidyl peptidase IV suppress lymphocyte proliferation and immunoglobulin synthesis in vitro.

  Ekkehard Schön;Sigbert Jahn;Stephan T. Kiessig;Hans-Ulrich Demuth

  228
  Citations

• Investigation of glucose-dependent insulinotropic polypeptide-(1-42) and glucagon-like peptide-1-(7-36) degradation in vitro by dipeptidyl peptidase IV using matrix-assisted laser desorption/ionization-time of flight mass spectrometry. A novel kinetic approach.

  Robert P. Pauly;Fred Rosche;Michael Wermann;Christopher H.S. McIntosh

  225
  Citations

• Prodrugs of dipeptidyl peptidase IV inhibitors, pharmaceutical compositions and uses thereof

  Demuth Hans-Ulrich;Hoffmann Torsten;Schlenzig Dagmar;Manhart Susanne

  222
  Citations

• Intraneuronal pyroglutamate-Abeta 3-42 triggers neurodegeneration and lethal neurological deficits in a transgenic mouse model.

  Oliver Wirths;Henning Breyhan;Holger Cynis;Stephan Schilling

  212
  Citations

• Metformin effects on dipeptidylpeptidase IV degradation of glucagon-like peptide-1.

  Simon A. Hinke;Kerstin Kühn-Wache;Torsten Hoffmann;Raymond A. Pederson

  208
  Citations

• Glutaminyl cyclases unfold glutamyl cyclase activity under mild acid conditions.

  Stephan Schilling;Torsten Hoffmann;Susanne Manhart;Matthias Hoffmann

  197
  Citations

• Long-term treatment with dipeptidyl peptidase IV inhibitor improves hepatic and peripheral insulin sensitivity in the VDF Zucker rat: a euglycemic-hyperinsulinemic clamp study.

  John A. Pospisilik;Sara G. Stafford;Hans-Ulrich Demuth;Christopher H.S. McIntosh

  182
  Citations

• Dipeptidyl peptidase IV in the immune system. Effects of specific enzyme inhibitors on activity of dipeptidyl peptidase IV and proliferation of human lymphocytes.

  Ekkehard Schön;Ilona Born;Hans-Ulrich Demuth;Jürgen Faust

  156
  Citations

• Dipeptidyl Peptidase IV (DPIV/CD26) Degradation of Glucagon CHARACTERIZATION OF GLUCAGON DEGRADATION PRODUCTS AND DPIV-RESISTANT ANALOGS

  Simon Amadeus Hinke;J. Andrew Pospisilik;Hans Ulrich Demuth;Susanne Mannhart

  156
  Citations

• Modulation of inositol 1,4,5-triphosphate concentration by prolyl endopeptidase inhibition.

  Ingo Schulz;Bernd Gerhartz;Antje Neubauer;Andreas Holloschi

  155
  Citations