Dieter Brömme

Research.com Recognitions

• 2023 - Research.com Biology and Biochemistry in Canada Leader Award

Overview

Best Publications

• Lysosomal Protease Pathways to Apoptosis: CLEAVAGE OF Bid, NOT PRO-CASPASES, IS THE MOST LIKELY ROUTE *

  Veronika Stoka;Veronika Stoka;Boris Turk;Sharon L. Schendel;Tae Hyoung Kim

  879
  Citations

• Vinyl sulfones as mechanism-based cysteine protease inhibitors.

  James T. Palmer;David Rasnick;Jeffrey L. Klaus;Dieter Bromme

  740
  Citations

• Essential Role for Cathepsin S in MHC Class II–Associated Invariant Chain Processing and Peptide Loading

  Richard J Riese;Paula R Wolf;Dieter Brömme;Lisa R Natkin

  713
  Citations

• Human and parasitic papain-like cysteine proteases: their role in physiology and pathology and recent developments in inhibitor design.

  Fabien Lecaille;Jadwiga Kaleta;Dieter Brömme

  712
  Citations

• Human Cathepsin O2, a Matrix Protein-degrading Cysteine Protease Expressed in Osteoclasts FUNCTIONAL EXPRESSION OF HUMAN CATHEPSIN O2 IN SPODOPTERA FRUGIPERDA AND CHARACTERIZATION OF THE ENZYME

  Dieter Brömme;Kathleen Okamoto;Bruce B. Wang;Sandra Biroc

  651
  Citations

• Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2

  Stephan K. Böhm;Wuyi Kong;Dieter Brömme;Steven P. Smeekens

  560
  Citations

• Substrate profiling of cysteine proteases using a combinatorial peptide library identifies functionally unique specificities.

  Youngchool Choe;Francesco Leonetti;Doron C. Greenbaum;Fabien Lecaille

  499
  Citations

• Human cathepsin K cleaves native type I and II collagens at the N-terminal end of the triple helix

  W. Kafienah;D. Brömme;D.J. Buttle;L.J. Croucher

  435
  Citations

• The role of cathepsins in osteoporosis and arthritis: rationale for the design of new therapeutics.

  Yoshiyuki Yasuda;Jadwiga Kaleta;Dieter Brömme

  399
  Citations

• Human cathepsin O2, a novel cysteine protease highly expressed in osteoclastomas and ovary molecular cloning, sequencing and tissue distribution.

  Dieter Brömme;Kathleen Okamoto

  358
  Citations

• Cross-Class Inhibition of the Cysteine Proteinases Cathepsins K, L, and S by the Serpin Squamous Cell Carcinoma Antigen 1: A Kinetic Analysis†

  Charles Schick;Philip A. Pemberton;Guo-Ping Shi;Yoshiro Kamachi

  331
  Citations

• Role for Cathepsin F in Invariant Chain Processing and Major Histocompatibility Complex Class II Peptide Loading by Macrophages

  Guo-Ping Shi;Rebecca A.R. Bryant;Richard Riese;Steven Verhelst

  296
  Citations

• Cathepsin S from bovine spleen. Purification, distribution, intracellular localization and action on proteins.

  H Kirschke;B Wiederanders;D Brömme;A Rinne

  290
  Citations

• Regulation of Collagenase Activities of Human Cathepsins by Glycosaminoglycans

  Zhenqiang Li;Yoshiyuki Yasuda;Weijie Li;Matthew Bogyo

  282
  Citations

• Cathepsin K Activity-dependent Regulation of Osteoclast Actin Ring Formation and Bone Resorption

  Susan R. Wilson;Christoph Peters;Paul Saftig;Dieter Brömme

  276
  Citations

• Human Cathepsin V Functional Expression, Tissue Distribution, Electrostatic Surface Potential, Enzymatic Characterization, and Chromosomal Localization‡

  Dieter Brömme;Zhenqiang Li;Michel Barnes;Ernest Mehler

  276
  Citations

• Pivotal Role of Cathepsin K in Lung Fibrosis

  Frank Bühling;Christoph Röcken;Frank Brasch;Roland Hartig

  262
  Citations

• Cathepsin K inhibitors for osteoporosis and potential off-target effects.

  Dieter Brömme;Fabien Lecaille

  255
  Citations

• Cathepsin K Is a Critical Protease in Synovial Fibroblast-Mediated Collagen Degradation

  Wu-Shiun Hou;Zhenqiang Li;Ronald E. Gordon;Kyle Chan

  253
  Citations

• Inhibition of papain-like cysteine proteases and legumain by caspase-specific inhibitors: when reaction mechanism is more important than specificity

  J Rozman-Pungercar;N Kopitar-Jerala;M Bogyo;M Bogyo;D Turk

  245
  Citations