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D-Index & Metrics

Biology and Biochemistry

D-Index
110
Citations
37255
World Ranking
979
National Ranking
600

Overview

James H. McKerrow is affiliated with the University of California, San Diego in the United States and has a research focus that spans several fields of study within Medicine. Their work includes significant contributions in Public Health, Environmental and Occupational Health, Epidemiology, Infectious Diseases, Molecular Biology, and Organic Chemistry.

The scientist's research topics are diverse, with notable emphasis on parasitology and infectious diseases. Key areas of investigation include Trypanosoma species research and implications, studies on Leishmaniasis, computational drug discovery methods, SARS-CoV-2 and COVID-19 research, synthesis and biological evaluation, parasites and host interactions, and bioactive compounds and antitumor agents.

Selected recent papers authored by James H. McKerrow encompass the following:

  • A Clinical-Stage Cysteine Protease Inhibitor blocks SARS-CoV-2 Infection of Human and Monkey Cells, 2021, ACS Chemical Biology
  • Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L, 2021, Journal of Medicinal Chemistry
  • Small-Molecule Thioesters as SARS-CoV-2 Main Protease Inhibitors: Enzyme Inhibition, Structure-Activity Relationships, Antiviral Activity, and X-ray Structure Determination, 2022, Journal of Medicinal Chemistry
  • Computer-aided design of 1,4-naphthoquinone-based inhibitors targeting cruzain and rhodesain cysteine proteases, 2021, Bioorganic & Medicinal Chemistry
  • Herbal melanin inhibits colorectal cancer cell proliferation by altering redox balance, inducing apoptosis, and modulating MAPK signaling, 2020, Cancer Cell International

Frequent publication venues for McKerrow include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Medicinal Chemistry
  • Pathogens
  • PLoS neglected tropical diseases
  • ACS Chemical Biology

James H. McKerrow has collaborated extensively with several researchers. Frequent co-authors include Jair L. Siqueira-Neto with 23 joint publications, Anthony J. O'Donoghue with 13, Elany Barbosa da Silva with 12, Miriam A. Giardini with 10, and Pavla Fajtová with 9.

Best Publications

  • Cysteine proteases of parasitic organisms

    M. Sajid;J.H. McKerrow

  • Protease inhibitors targeting coronavirus and filovirus entry

    Yanchen Zhou;Punitha Vedantham;Kai Lu;Juliet Agudelo

  • Tumour necrosis factor α restores granulomas and induces parasite egg-laying in schistosome-infected SCID mice

    P Amiri;R M Locksley;T G Parslow;M Sadick

  • In Vitro Antimalarial Activity of Chalcones and Their Derivatives

    Rongshi Li;George L. Kenyon;Fred E. Cohen;Xiaowu Chen

  • The Proteases and Pathogenicity of Parasitic Protozoa

    James H. McKerrow;Eugene Sun;Philip J. Rosenthal;Jacques Bouvier

  • Synthesis and Structure−Activity Relationship Study of Potent Trypanocidal Thio Semicarbazone Inhibitors of the Trypanosomal Cysteine Protease Cruzain

    Xiaohui Du;Chun Guo;Elizabeth Hansell;Patricia S Doyle

  • Cysteine Protease Inhibitors Cure an Experimental Trypanosoma cruzi Infection

    Juan C. Engel;Patricia S. Doyle;Ivy Hsieh;James H. McKerrow

  • PROTEASES IN PARASITIC DISEASES

    James H McKerrow;Conor Caffrey;Ben Kelly;P'ng Loke

  • IL-13 Activates a Mechanism of Tissue Fibrosis That Is Completely TGF-β Independent

    Mallika Kaviratne;Matthias Hesse;Mary Leusink;Allen W. Cheever

  • A malarial cysteine proteinase is necessary for hemoglobin degradation by Plasmodium falciparum.

    P J Rosenthal;J H McKerrow;M Aikawa;H Nagasawa

  • Drug discovery and development for neglected parasitic diseases

    Adam R Renslo;James H McKerrow

  • Structure-based inhibitor design by using protein models for the development of antiparasitic agents.

    Christine S. Ring;Eugene Sun;James H. McKerrow;Garson K. Lee

  • The sequence, organization, and expression of the major cysteine protease (cruzain) from Trypanosoma cruzi.

    A.E. Eakin;A.A. Mills;G Harth;J.H. McKerrow

  • Synthesis and structure-activity relationships of parasiticidal thiosemicarbazone cysteine protease inhibitors against Plasmodium falciparum, Trypanosoma brucei, and Trypanosoma cruzi.

    Doron C. Greenbaum;Zachary Mackey;Elizabeth Hansell;Patricia Doyle

  • Controlled deamidation of peptides and proteins: an experimental hazard and a possible biological timer.

    Arthur B. Robinson;James H. McKerrow;Paul Cary

  • Schistosomiasis Mansoni: Novel Chemotherapy Using a Cysteine Protease Inhibitor

    Maha-Hamadien Abdulla;Kee-Chong Lim;Mohammed Sajid;James H McKerrow

  • A high throughput drug screen for Entamoeba histolytica identifies a new lead and target

    Anjan Debnath;Derek Parsonage;Rosa M. Andrade;Chen-chen He

  • Vinyl sulfones as antiparasitic agents and a structural basis for drug design.

    Iain D. Kerr;Ji Hyun Lee;Christopher J. Farady;Rachael Marion

  • The crystal structure of cruzain: a therapeutic target for Chagas' disease.

    Mary E. McGrath;Ann E. Eakin;Juan C. Engel;James H. McKerrow

  • Cysteine protease inhibitors as chemotherapy for parasitic infections

    James H McKerrow;Juan C Engel;Conor R Caffrey

Frequent Co-Authors

Conor R. Caffrey
Conor R. Caffrey University of Montana
Mohammed Sajid
Mohammed Sajid Leiden University Medical Center
Charles S. Craik
Charles S. Craik University of California, San Francisco
William R. Roush
William R. Roush Scripps Research Institute
Philip J. Rosenthal
Philip J. Rosenthal University of California, San Francisco
Fred E. Cohen
Fred E. Cohen University of California, San Francisco
Jiri Gut
Jiri Gut University of California, San Francisco
Michelle R. Arkin
Michelle R. Arkin University of California, San Francisco
Sharon L. Reed
Sharon L. Reed University of California, San Diego
George L. Kenyon
George L. Kenyon University of California, San Francisco

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