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Chemistry

D-Index
49
Citations
8498
World Ranking
14831
National Ranking
1085

Biology and Biochemistry

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47
Citations
8008
World Ranking
18711
National Ranking
1282

Overview

Tanja Schirmeister is affiliated with the Johannes Gutenberg University of Mainz in Germany. Their research spans multiple fields within life sciences, particularly focusing on medicine and biochemistry, genetics, and molecular biology. The main subfields of study addressed in their work include molecular biology, organic chemistry, public health, environmental and occupational health, materials chemistry, and epidemiology.

Schirmeister's scholarly output encompasses a variety of significant topics, with notable emphasis on Trypanosoma species research and implications, studies on leishmaniasis, crystallization and solubility, computational drug discovery methods, mosquito-borne diseases and control, X-ray diffraction in crystallography, and SARS-CoV-2 and COVID-19 research.

Their publication record demonstrates contributions to prominent scientific venues. Frequent publication venues include:

  • The Cambridge Structural Database
  • ChemMedChem
  • Molecules
  • International Journal of Molecular Sciences
  • European Journal of Medicinal Chemistry

Several papers by Schirmeister have addressed pressing biomedical questions. Recent publications include:

  • "Lead Discovery of SARS-CoV-2 Main Protease Inhibitors through Covalent Docking-Based Virtual Screening" (2021) in the Journal of Chemical Information and Modeling
  • "Structure-Activity Relationships of Benzamides and Isoindolines Designed as SARS-CoV Protease Inhibitors Effective against SARS-CoV-2" (2020) in ChemMedChem
  • "Novel Opportunities for Cathepsin S Inhibitors in Cancer Immunotherapy by Nanocarrier-Mediated Delivery" (2020) in Cells
  • "SAR of novel benzothiazoles targeting an allosteric pocket of DENV and ZIKV NS2B/NS3 proteases" (2021) in Bioorganic & Medicinal Chemistry
  • "Fluorovinylsulfones and -Sulfonates as Potent Covalent Reversible Inhibitors of the Trypanosomal Cysteine Protease Rhodesain: Structure-Activity Relationship, Inhibition Mechanism, Metabolism, and In Vivo Studies" (2021) in the Journal of Medicinal Chemistry

The scientist collaborates frequently with several coauthors, reflecting interdisciplinary teamwork. Prominent frequent coauthors are:

  • Stefan Hammerschmidt
  • Christian Kersten
  • Collin Zimmer
  • Fabian Barthels
  • Nicola Micale

These cooperative relationships likely contribute to the diversity of topics and approaches within their corpus, including computational methods, molecular drug design, and infectious disease research.

Best Publications

  • Cysteine Proteases and Their Inhibitors.

    Hans-Hartwig Otto;Tanja Schirmeister

  • Development of Peptidomimetics with a Vinyl Sulfone Warhead as Irreversible Falcipain-2 Inhibitors

    Roberta Ettari;Emanuela Nizi;Maria Emilia Di Francesco;Marie-Adrienne Dude

  • Biochemistry and Medicinal Chemistry of the Dengue Virus Protease

    Christoph Nitsche;Steven Holloway;Tanja Schirmeister;Christian D. Klein

  • Novel Dengue Virus NS2B/NS3 Protease Inhibitors

    Hongmei Wu;Stefanie Bock;Mariya Snitko;Thilo Berger

  • Flavonoids as noncompetitive inhibitors of Dengue virus NS2B-NS3 protease: Inhibition kinetics and docking studies

    Lorena Ramos Freitas de Sousa;Hongmei Wu;Liliane Nebo;João Batista Fernandes

  • Metabolomics analysis and biological investigation of three Malvaceae plants

    Omnia Hesham Abdelhafez;Eman Maher Othman;John Refaat Fahim;Samar Yehia Desoukey

  • Prospective Evaluation of Free Energy Calculations for the Prioritization of Cathepsin L Inhibitors

    Bernd Kuhn;Michal Tichý;Lingle Wang;Shaughnessy Robinson

  • Transcriptome and Functional Analysis of the Eukaryotic-Type Serine/Threonine Kinase PknB in Staphylococcus aureus

    Stefanie Donat;Karin Streker;Tanja Schirmeister;Sonja Rakette

  • Inhibitors of cysteine proteases.

    Radim Vicik;Matthias Busemann;Knut Baumann;Tanja Schirmeister

  • The significance of ionic bonding in sulfur dioxide: bond orders from X-ray diffraction data.

    Simon Grabowsky;Peter Luger;Jürgen Buschmann;Thomas Schneider

  • Evidence for substrate binding-induced zwitterion formation in the catalytic Cys-His dyad of the SARS-CoV main protease.

    Alexander Paasche;Andreas Zipper;Simon Schäfer;John Ziebuhr

  • Aziridine-2,3-dicarboxylate inhibitors targeting the major cysteine protease of Trypanosoma brucei as lead trypanocidal agents.

    Radim Vicik;Verena Hoerr;Melanie Glaser;Martina Schultheis

  • Antioxidant and anti-protease activities of diazepinomicin from the sponge-associated Micromonospora strain RV115.

    Usama Ramadan Abdelmohsen;Matthias Szesny;Eman Maher Othman;Tanja Schirmeister

  • Allicin and derivates are cysteine protease inhibitors with antiparasitic activity.

    Thilo Waag;Christoph Gelhaus;Jennifer Rath;August Stich

  • New peptidic cysteine protease inhibitors derived from the electrophilic alpha-amino acid aziridine-2,3-dicarboxylic acid.

    Tanja Schirmeister

  • Aziridine-2,3-Dicarboxylates, Peptidomimetic Cysteine Protease Inhibitors with Antileishmanial Activity

    Alicia Ponte-Sucre;Radim Vicik;Martina Schultheis;Tanja Schirmeister

  • Theoretical studies about the influence of different ring substituents on the nucleophilic ring opening of three-membered heterocycles and possible implications for the mechanisms of cysteine protease inhibitors.

    Holger Helten;Tanja Schirmeister;Bernd Engels

  • Novel peptidomimetics containing a vinyl ester moiety as highly potent and selective falcipain-2 inhibitors.

    Roberta Ettari;Nicola Micale;Tanja Schirmeister;Christoph Gelhaus

  • Aziridinyl peptides as inhibitors of cysteine proteases: effect of a free carboxylic acid function on inhibition.

    T. Schirmeister;M. Peric

  • Proline-Based Allosteric Inhibitors of Zika and Dengue Virus NS2B/NS3 Proteases

    Benedikt Millies;Franziska von Hammerstein;Andrea Gellert;Stefan Hammerschmidt

  • On the origin of the stabilization of the zwitterionic resting state of cysteine proteases: a theoretical study.

    Milena Mladenovic;Reinhold F. Fink;Walter Thiel;Tanja Schirmeister

Frequent Co-Authors

Bernd Engels
Bernd Engels University of Würzburg
Matthias Leippe
Matthias Leippe Kiel University
Marcel Kaiser
Marcel Kaiser Swiss Tropical and Public Health Institute
Peter Luger
Peter Luger Freie Universität Berlin
Reto Brun
Reto Brun University of Basel
Carsten Schmuck
Carsten Schmuck University of Duisburg-Essen
Dylan Jayatilaka
Dylan Jayatilaka University of Western Australia
Philip J. Rosenthal
Philip J. Rosenthal University of California, San Francisco
Ettore Novellino
Ettore Novellino University of Naples Federico II

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