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Michael Gütschow

Michael Gütschow

D-Index & Metrics

Chemistry

D-Index
54
Citations
9654
World Ranking
12679
National Ranking
933

Overview

Michael Gütschow is affiliated with the University of Bonn in Germany. Their research spans multiple areas within biochemistry, genetics, molecular biology, and medicine. They have contributed to a broad range of scientific fields, with a substantial focus on molecular biology and organic chemistry, as well as oncology, infectious diseases, and computational theory and mathematics.

Their notable recent publications include:

  • "Dysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injury" (2021, Nature Communications)
  • "E3 Ligase Ligands in Successful PROTACs: An Overview of Syntheses and Linker Attachment Points" (2021, Frontiers in Chemistry)
  • "Targeting the Main Protease of SARS-CoV-2: From the Establishment of High Throughput Screening to the Design of Tailored Inhibitors" (2021, Angewandte Chemie International Edition)
  • "3CL Protease Inhibitors with an Electrophilic Arylketone Moiety as Anti-SARS-CoV-2 Agents" (2021, Journal of Medicinal Chemistry)
  • "Systematic exploration of different E3 ubiquitin ligases: an approach towards potent and selective CDK6 degraders" (2020, Chemical Science)

Their main research topics encompass:

  • Protein Degradation and Inhibitors
  • Ubiquitin and proteasome pathways
  • Computational Drug Discovery Methods
  • Peptidase Inhibition and Analysis
  • Multiple Myeloma Research and Treatments
  • SARS-CoV-2 and COVID-19 Research
  • Click Chemistry and Applications

Michael Gütschow's frequent coauthors include:

  • Christian Steinebach
  • Christa E. Müller
  • Izidor Sosič
  • Carina Lemke
  • Katharina Sylvester

The venues where Gütschow has most frequently published include:

  • Journal of Medicinal Chemistry
  • ACS Pharmacology & Translational Science
  • Archiv der Pharmazie
  • ChemMedChem
  • Nature Communications

The scientist's work integrates approaches from molecular biology and chemistry to advance understanding of biochemical pathways and develop pharmaceutical agents. Their investigations into proteasome pathways, ubiquitin ligases, and drug discovery methods contribute to therapeutic research, including studies addressing SARS-CoV-2.

Best Publications

  • RECENT DEVELOPMENTS IN HYDANTOIN CHEMISTRY. A REVIEW

    Manuela Meusel;Michael Gütschow

  • Degradation of Quercetin and Luteolin by Eubacterium ramulus

    Annett Braune;Michael Gütschow;Wolfram Engst;Michael Blaut

  • Dysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injury.

    Wulf Tonnus;Claudia Meyer;Christian Steinebach;Alexia Belavgeni

  • Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-6.

    Arduino A. Mangoni;Catherine Guillou;Jean Jacques Vanden Eynde;Christopher Hulme

  • E3 Ligase Ligands in Successful PROTACs: An Overview of Syntheses and Linker Attachment Points.

    Aleša Bricelj;Christian Steinebach;Robert Kuchta;Michael Gütschow

  • Conversion of daidzein and genistein by an anaerobic bacterium newly isolated from the mouse intestine.

    Anastasia Matthies;Thomas Clavel;Michael Gütschow;Wolfram Engst

  • Development of Nitrile-Based Peptidic Inhibitors of Cysteine Cathepsins

    Maxim Frizler;Marit Stirnberg;Mihiret Tekeste Sisay;Michael Gutschow

  • Calcium-sensing receptors signal constitutive macropinocytosis and facilitate the uptake of NOD2 ligands in macrophages

    Johnathan Canton;Daniel Schlam;Christian Breuer;Michael Gütschow

  • Homo-PROTACs for the Chemical Knockdown of Cereblon

    Christian Steinebach;Stefanie Lindner;Namrata D. Udeshi;Deepak C. Mani

  • Synthesis of tricyclic 1,3-oxazin-4-ones and kinetic analysis of cholesterol esterase and acetylcholinesterase inhibition.

    Markus Pietsch;Michael Gütschow

  • 2-(Diethylamino)thieno[1,3]oxazin-4-ones as Stable Inhibitors of Human Leukocyte Elastase

    Michael Gütschow;Lars Kuerschner;Ulf Neumann;Markus Pietsch

  • Targeting the Main Protease of SARS-CoV-2: From the Establishment of High Throughput Screening to the Design of Tailored Inhibitors.

    Julian Breidenbach;Carina Lemke;Thanigaimalai Pillaiyar;Thanigaimalai Pillaiyar;Laura Schäkel

  • Regulation of TMPRSS6 by BMP6 and iron in human cells and mice.

    Delphine Meynard;Valentina Vaja;Valentina Vaja;Chia Chi Sun;Elena Corradini

  • Systematic exploration of different E3 ubiquitin ligases: an approach towards potent and selective CDK6 degraders

    Christian Steinebach;Yuen Lam Dora Ng;Izidor Sosič;Chih-Shia Lee

  • Antiangiogenic activity of N-substituted and tetrafluorinated thalidomide analogues.

    Sylvia S W Ng;Michael Gütschow;Michael Weiss;Sunna Hauschildt

  • 3CL Protease Inhibitors with an Electrophilic Arylketone Moiety as Anti-SARS-CoV-2 Agents.

    Sho Konno;Kiyotaka Kobayashi;Miki Senda;Yuta Funai

  • Interaction of papain-like cysteine proteases with dipeptide-derived nitriles.

    Reik Löser;Klaus Schilling;and Elke Dimmig;Michael Gütschow

  • Antimicrobial phenalenone derivatives from the marine-derived fungus Coniothyrium cereale.

    Mahmoud Fahmi Elsebai;Stefan Kehraus;Ulrike Lindequist;Florenz Sasse

  • Azadipeptide nitriles: highly potent and proteolytically stable inhibitors of papain-like cysteine proteases.

    Reik Löser;Maxim Frizler;Klaus Schilling;Michael Gütschow

  • Structural Optimization of Azadipeptide Nitriles Strongly Increases Association Rates and Allows the Development of Selective Cathepsin Inhibitors

    Maxim Frizler;Friederike Lohr;Norbert Furtmann;Julia Kläs

  • Dual Targeting of Adenosine A2A Receptors and Monoamine Oxidase B by 4H-3,1-Benzothiazin-4-ones

    Anne Stößel;Miriam Schlenk;Sonja Hinz;Petra Küppers

Frequent Co-Authors

Jürgen Bajorath
Jürgen Bajorath University of Bonn
Christa E. Müller
Christa E. Müller University of Bonn
Gregor Schnakenburg
Gregor Schnakenburg University of Bonn
Gabriele M. König
Gabriele M. König University of Bonn
Michael Blaut
Michael Blaut University of Potsdam
William D. Figg
William D. Figg National Institutes of Health
Evi Kostenis
Evi Kostenis University of Bonn
Martin Nieger
Martin Nieger University of Helsinki
Bernd K. Fleischmann
Bernd K. Fleischmann University of Bonn
Wilhelm Schänzer
Wilhelm Schänzer German Sport University Cologne

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