World's Best Scientists 2026 revealed!
Award Badge
Biology and Biochemistry
Canada
2026

D-Index & Metrics

Biology and Biochemistry

D-Index
149
Citations
80939
World Ranking
189
National Ranking
6

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in Canada Leader Award
  • 2025 - Research.com Biology and Biochemistry in Canada Leader Award
  • 2023 - Research.com Biology and Biochemistry in Canada Leader Award
  • 2022 - Research.com Biology and Biochemistry in Canada Leader Award
  • 2000 - Fellow of the Royal Society of Canada Academy of Science

Overview

Sergio Grinstein is affiliated with the Hospital for Sick Children in Canada. Their research spans multiple areas within biochemistry, genetics, molecular biology, and medicine, with a particular focus on cellular and immune processes.

The main fields of study for Grinstein include:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Their subfields cover various aspects of cell and immune biology:

  • Molecular Biology
  • Immunology
  • Cell Biology
  • Physiology
  • Surgery

Grinstein's work prominently addresses several research topics including:

  • Cellular transport and secretion
  • Erythrocyte Function and Pathophysiology
  • Phagocytosis and Immune Regulation
  • Calcium signaling and nucleotide metabolism
  • Lipid Membrane Structure and Behavior
  • Pancreatic function and diabetes
  • Cell Adhesion Molecules Research

The scientist has co-authored publications frequently with colleagues such as Spencer A. Freeman, Michelle E. Maxson, Johannes Westman, Glenn F. W. Walpole, and Jonathan Plumb.

Grinstein has contributed to a variety of journals and publication venues, with frequent appearances in:

  • Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • The Journal of Cell Biology
  • Current Biology

Notable recent papers include:

  • The cytoskeleton in phagocytosis and macropinocytosis, 2021, Current Biology
  • Lipid peroxidation increases membrane tension, Piezo1 gating, and cation permeability to execute ferroptosis, 2023, Current Biology
  • Phagocytosis of Necrotic Debris at Sites of Injury and Inflammation, 2020, Frontiers in Immunology
  • Lysosome Fusion Maintains Phagosome Integrity during Fungal Infection, 2020, Cell Host & Microbe
  • Determinants, maintenance, and function of organellar pH, 2022, Physiological Reviews

Grinstein was awarded the title of Fellow of the Royal Society of Canada in 2000, recognized by the Academy of Science. This affiliation marks a notable aspect of their career.

Best Publications

  • Sensors and regulators of intracellular pH

    Joseph R. Casey;Sergio Grinstein;John Orlowski

  • Robust single-particle tracking in live-cell time-lapse sequences.

    Khuloud Jaqaman;Dinah Loerke;Marcel Mettlen;Hirotaka Kuwata

  • Membrane phosphatidylserine regulates surface charge and protein localization

    Tony Yeung;Gary E. Gilbert;Jialan Shi;John Silvius

  • The Cell Biology of Phagocytosis

    Ronald S. Flannagan;Valentin Jaumouillé;Sergio Grinstein

  • Antimicrobial mechanisms of phagocytes and bacterial evasion strategies

    Ronald S. Flannagan;Gabriela Cosío;Sergio Grinstein

  • The distribution and function of phosphatidylserine in cellular membranes.

    Peter A Leventis;Sergio Grinstein

  • Na+/H+ exchange and growth factor-induced cytosolic pH changes. Role in cellular proliferation.

    Sergio Grinstein;Daniela Rotin;Michael J. Mason

  • Amiloride inhibits macropinocytosis by lowering submembranous pH and preventing Rac1 and Cdc42 signaling

    Mirkka Koivusalo;Christopher Welch;Hisayoshi Hayashi;Cameron C Scott

  • Phagocytosis and innate immunity.

    Steven Greenberg;Sergio Grinstein

  • Scavenger receptors in homeostasis and immunity

    Johnathan Canton;Dante Neculai;Sergio Grinstein;Sergio Grinstein

  • Mechanisms of regulation of the Na+/H+ exchanger

    Sergio Grinstein;Ase Rothstein

  • Phagosome maturation: aging gracefully.

    Otilia V. Vieira;Roberto J. Botelho;Sergio Grinstein

  • The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9.

    Koichi Tabeta;Kasper Hoebe;Edith M. Janssen;Xin Du

  • Diversity of the mammalian sodium/proton exchanger SLC9 gene family.

    John Orlowski;Sergio Grinstein

  • LAMP proteins are required for fusion of lysosomes with phagosomes.

    Kassidy K Huynh;Eeva-Liisa Eskelinen;Cameron C Scott;Anatoly Malevanets

  • The beta2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange.

    Randy A. Hall;Richard T. Premont;Chung-Wai Chow;Jeremy T. Blitzer

  • Na+/H+ Exchangers of Mammalian Cells *

    John Orlowski;Sergio Grinstein

  • Localized biphasic changes in phosphatidylinositol-4,5-bisphosphate at sites of phagocytosis

    Roberto J. Botelho;Mary Teruel;Renee Dierckman;Richard Anderson

  • Distinct roles of class I and class III phosphatidylinositol 3-kinases in phagosome formation and maturation

    Otilia V. Vieira;Otilia V. Vieira;Roberto J. Botelho;Lucia Rameh;Saskia M. Brachmann;Saskia M. Brachmann

  • Activation of antibacterial autophagy by NADPH oxidases

    Ju Huang;Veronica Canadien;Grace Y. Lam;Benjamin E. Steinberg

Frequent Co-Authors

Gregory P. Downey
Gregory P. Downey National Jewish Health
John H. Brumell
John H. Brumell University of Toronto
John Orlowski
John Orlowski McGill University
Ori D. Rotstein
Ori D. Rotstein University of Toronto
William S. Trimble
William S. Trimble University of Toronto
Richard F. Collins
Richard F. Collins University of Manchester
Aser Rothstein
Aser Rothstein University of Rochester
Alan D. Schreiber
Alan D. Schreiber University of Pennsylvania
Andras Kapus
Andras Kapus University of Toronto
Gordon B. Mills
Gordon B. Mills Oregon Health & Science University

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Exploring Biology and Biochemistry can open exciting doors to specialized roles in healthcare, research, and technology. For students seeking flexible study options, online degrees in health science and related fields offer an accessible path to grow your expertise and improve your career prospects.

One option is an cheapest online mba healthcare program, which blends business knowledge with medical industry insights. This path is ideal for those interested in healthcare management, policy, or administration.

Another growing field is medical billing and coding. If you’re comparing career certificates, understanding ccs vs cpc salary can help you choose the best certification for your goals. Both credentials pave the way for roles in hospitals, clinics, and insurance.

Medical coders play a critical part in the healthcare system, with strong earning potential. Recent trends in medical.coding salary indicate a steady demand for skilled professionals.

Curious about entering this profession? Learn more about the pros and cons to decide is medical coding a good job for you.

Best Scientists Citing Sergio Grinstein

Trending Scientists