World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
87
Citations
27025
World Ranking
2832
National Ranking
1455

Research.com Recognitions

  • 2002 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Mark Donowitz is affiliated with Johns Hopkins University School of Medicine in the United States. Their research spans multiple fields, primarily focusing on medicine, biochemistry, genetics, and molecular biology.

Their work extensively explores topics such as drug transport and resistance mechanisms, ion transport and channel regulation, digestive system and related health issues, cancer cells and metastasis, pancreatic function and diabetes, cystic fibrosis research advances, and gastrointestinal motility and disorders.

Mark Donowitz has contributed to a significant number of publications in prominent venues. Frequent publication sites include:

  • Gastroenterology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • American Journal of Physiology-Cell Physiology
  • The FASEB Journal
  • Cellular and Molecular Gastroenterology and Hepatology

Frequent co-authors in their work are:

  • Ruxian Lin
  • Varsha Singh
  • Rafiquel Sarker
  • Nicholas C. Zachos
  • Jennifer Foulke-Abel

Some recent notable papers authored or co-authored by Mark Donowitz include:

  • Duodenum Intestine-Chip for preclinical drug assessment in a human relevant model, 2020, eLife
  • Chronic Inflammation in Ulcerative Colitis Causes Long-Term Changes in Goblet Cell Function, 2021, Cellular and Molecular Gastroenterology and Hepatology
  • Mucus layer modeling of human colonoids during infection with enteroaggragative E. coli, 2020, Scientific Reports
  • Pleiotropic ZIP8 A391T implicates abnormal manganese homeostasis in complex human disease, 2020, JCI Insight
  • Patients' perspectives on the derivation and use of organoids, 2021, Stem Cell Reports

Their subfields of study include molecular biology, oncology, surgery, genetics, and infectious diseases, reflecting a multidisciplinary approach to biomedical research.

Mark Donowitz was awarded the distinction of Fellow of the American Association for the Advancement of Science (AAAS) in 2002, recognizing their contributions to science.

Best Publications

  • The burden of selected digestive diseases in the United States

    Robert S. Sandler;James E. Everhart;Mark Donowitz;Elizabeth Adams

  • The Protein Kinase Akt Induces Epithelial Mesenchymal Transition and Promotes Enhanced Motility and Invasiveness of Squamous Cell Carcinoma Lines

    Sylvia Julien Grille;Alfonso Bellacosa;John Upson;Andres J. Klein-Szanto

  • TAZ: A novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins

    Fumihiko Kanai;Paola A. Marignani;Dilara Sarbassova;Ryohei Yagi;Ryohei Yagi

  • Evolutionary origins of eukaryotic sodium/proton exchangers.

    Christopher L. Brett;Mark Donowitz;Rajini Rao

  • cAMP-mediated inhibition of the epithelial brush border Na+/H+ exchanger, NHE3, requires an associated regulatory protein.

    C. H Chris Yun;Soohyuk Oh;Mirza Zizak;Deborah Steplock;Deborah Steplock

  • A primary human macrophage-enteroid co-culture model to investigate mucosal gut physiology and host-pathogen interactions.

    Gaelle Noel;Nicholas W. Baetz;Janet F. Staab;Mark Donowitz

  • Molecular physiology of intestinal Na+/H+ exchange

    Nicholas C. Zachos;Ming Tse;Mark Donowitz

  • Cloning and sequencing of a rabbit cDNA encoding an intestinal and kidney-specific Na+/H+ exchanger isoform (NHE-3).

    C M Tse;S R Brant;M S Walker;J Pouyssegur

  • Human Intestinal Enteroids: a New Model To Study Human Rotavirus Infection, Host Restriction, and Pathophysiology

    Kapil Saxena;Sarah E. Blutt;Khalil Ettayebi;Xi Lei Zeng

  • NHE2 and NHE3 are human and rabbit intestinal brush-border proteins.

    W. A. Hoogerwerf;S. C. Tsao;O. Devuyst;S. A. Levine

  • Na + /H + exchanger regulatory factor 2 directs parathyroid hormone 1 receptor signalling

    Matthew J. Mahon;Mark Donowitz;C. Chris Yun;Gino V. Segre

  • Mammalian Na+/H+ exchanger gene family: structure and function studies

    C. H C Yun;Chung Ming Tse;S. K. Nath;S. A. Levine

  • Akt as a mediator of cell death.

    Hongbo R. Luo;Hidenori Hattori;Mir Ahamed Hossain;Lynda Hester

  • Differential roles of NHERF1, NHERF2, and PDZK1 in regulating CFTR-mediated intestinal anion secretion in mice.

    Anurag Kumar Singh;Brigitte Riederer;Anja Krabbenhöft;Brigitte Rausch

  • SLC9/NHE gene family, a plasma membrane and organellar family of Na⁺/H⁺ exchangers

    Mark Donowitz;C. Ming Tse;Daniel Guido Fuster

  • Cloning and expression of a rabbit cDNA encoding a serum-activated ethylisopropylamiloride-resistant epithelial Na+/H+ exchanger isoform (NHE-2).

    Chung-Ming Tse;Susan A. Levine;C. H. Chris Yun;Marshall H. Montrose

  • Kinetics and regulation of three cloned mammalian Na+/H+ exchangers stably expressed in a fibroblast cell line.

    Susan A. Levine;Marshall H. Montrose;Chung Ming Tse;Mark Donowitz

  • NaCl uptake by the branchial epithelium in freshwater teleost fish: an immunological approach to ion-transport protein localization.

    J M Wilson;P Laurent;B L Tufts;D J Benos

  • Human Enteroids/Colonoids and Intestinal Organoids Functionally Recapitulate Normal Intestinal Physiology and Pathophysiology

    Nicholas C. Zachos;Olga Kovbasnjuk;Jennifer Foulke-Abel;Julie In

  • A Primary Human Macrophage-Enteroid Co-Culture Model to Investigate Mucosal Gut Physiology and Host-Pathogen Interactions

    Nicholas W. Baetz;Gaelle Noel;Janet Staab;Mark Donowitz

Frequent Co-Authors

C. Chris Yun
C. Chris Yun Emory University
Chung Ming Tse
Chung Ming Tse Johns Hopkins University School of Medicine
Hugo R. de Jonge
Hugo R. de Jonge Erasmus University Rotterdam
Edward J. Weinman
Edward J. Weinman University of Maryland, Baltimore
Mary K. Estes
Mary K. Estes Baylor College of Medicine
Steven R. Brant
Steven R. Brant Rutgers, The State University of New Jersey
Marshall H. Montrose
Marshall H. Montrose University of Cincinnati
Robert N. Cole
Robert N. Cole Johns Hopkins University School of Medicine
Alan S. Verkman
Alan S. Verkman University of California, San Francisco
Ann Louise Hubbard
Ann Louise Hubbard Johns Hopkins University School of Medicine

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