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Biology and Biochemistry

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Overview

Eugene B. Chang is affiliated with the University of Chicago in the United States. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a focus on several specialized subfields including Molecular Biology, Infectious Diseases, Genetics, Physiology, and Epidemiology.

The scientist's scholarly output centers on the interplay between gut microbiota and health, with particular attention to Inflammatory Bowel Disease, Clostridium difficile and Clostridium perfringens research, Microscopic Colitis, diet and metabolism studies, probiotics and fermented foods, and the dietary effects on health.

Frequent publication venues for their work include: bioRxiv (Cold Spring Harbor Laboratory), Gastroenterology, Journal of Clinical Investigation, Obstetrics and Gynecology, and Cell Host & Microbe.

Notable recent papers include:

  • "Inflammatory Bowel Diseases (IBD) and the Microbiome-Searching the Crime Scene for Clues" (2020, Gastroenterology)
  • "Intratumoral accumulation of gut microbiota facilitates CD47-based immunotherapy via STING signaling" (2020, The Journal of Experimental Medicine)
  • "The Gut Microbiome and Inflammatory Bowel Diseases" (2021, Annual Review of Medicine)
  • "Gut microbiota as a transducer of dietary cues to regulate host circadian rhythms and metabolism" (2021, Nature Reviews Gastroenterology & Hepatology)
  • "Droplet-based high-throughput cultivation for accurate screening of antibiotic resistant gut microbes" (2020, eLife)

The scientist collaborates regularly with several coauthors, including:

  • Candace M. Cham
  • David T. Rubin
  • Vanessa Leone
  • Orlando DeLeon
  • Ashley M. Sidebottom

Their research topics encompass:

  • Gut microbiota and health
  • Inflammatory Bowel Disease
  • Clostridium difficile and Clostridium perfringens research
  • Microscopic Colitis
  • Diet and metabolism studies
  • Probiotics and Fermented Foods
  • Dietary Effects on Health

Best Publications

  • Commensal Bifidobacterium promotes antitumor immunity and facilitates anti–PD-L1 efficacy

    Ayelet Sivan;Leticia Corrales;Nathaniel Hubert;Jason B. Williams

  • Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10 −/− mice

    Suzanne Devkota;Yunwei Wang;Mark W. Musch;Vanessa Leone

  • Commensal bacteria protect against food allergen sensitization

    Andrew T Stefka;Taylor Feehley;Prabhanshu Tripathi;Ju Qiu

  • Effects of diurnal variation of gut microbes and high-fat feeding on host circadian clock function and metabolism.

    Vanessa Leone;Sean M. Gibbons;Sean M. Gibbons;Kristina Martinez;Alan L. Hutchison

  • 16S rRNA gene-based analysis of fecal microbiota from preterm infants with and without necrotizing enterocolitis

    Yunwei Wang;Jeanette D. Hoenig;Kathryn J. Malin;Sanaa Qamar

  • Exercise Prevents Weight Gain and Alters the Gut Microbiota in a Mouse Model of High Fat Diet-Induced Obesity

    Christian C. Evans;Kathy J. LePard;Jeff W. Kwak;Mary C. Stancukas

  • Antibiotic-induced perturbations in gut microbial diversity influences neuro-inflammation and amyloidosis in a murine model of Alzheimer’s disease

    Myles R. Minter;Can Zhang;Vanessa Leone;Daina L. Ringus

  • Small Intestine Microbiota Regulate Host Digestive and Absorptive Adaptive Responses to Dietary Lipids

    Kristina Martinez-Guryn;Kristina Martinez-Guryn;Nathaniel Hubert;Katya Frazier;Saskia Urlass

  • Intestinal Electrolyte Transport and Diarrheal Disease

    Michael Field;Mrinalini C. Rao;Eugene B. Chang

  • The Human Microbiome and Obesity: Moving beyond Associations

    Padma Maruvada;Vanessa Leone;Lee M. Kaplan;Eugene B. Chang

  • Probiotics inhibit nuclear factor-κB and induce heat shock proteins in colonic epithelial cells through proteasome inhibition

    Elaine O. Petrof;Keishi Kojima;Mark J. Ropeleski;Mark W. Musch

  • Inflammatory Bowel Diseases (IBD) and the Microbiome-Searching the Crime Scene for Clues

    Mirae Lee;Eugene B. Chang

  • Chronic Sleep Disruption Alters Gut Microbiota, Induces Systemic and Adipose Tissue Inflammation and Insulin Resistance in Mice.

    Valeriy A. Poroyko;Valeriy A. Poroyko;Alba Carreras;Abdelnaby Khalyfa;Ahamed A. Khalyfa

  • Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host.

    Marlies Meisel;Reinhard Hinterleitner;Alain Pacis;Li Chen

  • Recognition of host immune activation by Pseudomonas aeruginosa

    Licheng Wu;Oscar Estrada;Olga Zaborina;Manjeet Bains

  • Soluble factors from Lactobacillus GG activate MAPKs and induce cytoprotective heat shock proteins in intestinal epithelial cells

    Yun Tao;Kenneth A. Drabik;Tonya S. Waypa;Mark W. Musch

  • Adenomatous Polyps Are Driven by Microbe-Instigated Focal Inflammation and Are Controlled by IL-10–Producing T Cells

    Kristen L. Dennis;Yunwei Wang;Nichole R. Blatner;Shuya Wang

  • Intestinal epithelial vitamin D receptor deletion leads to defective autophagy in colitis

    Shaoping Wu;Yong Guo Zhang;Rong Lu;Yinglin Xia

  • Glutamine induces heat shock protein and protects against endotoxin shock in the rat.

    Paul E. Wischmeyer;Madelyn Kahana;Rachel Wolfson;Hongyu Ren

  • Regional Diversity of the Gastrointestinal Microbiome.

    Kristina Martinez-Guryn;Vanessa Leone;Eugene B. Chang

Frequent Co-Authors

Mark W. Musch
Mark W. Musch University of Chicago
Marc Bissonnette
Marc Bissonnette University of Chicago
A. Murat Eren
A. Murat Eren Carl von Ossietzky University of Oldenburg
Jack A. Gilbert
Jack A. Gilbert University of California, San Diego
Bana Jabri
Bana Jabri University of Chicago
Jun Ichi Abe
Jun Ichi Abe The University of Texas MD Anderson Cancer Center
Yong Huang
Yong Huang Hong Kong University of Science and Technology
Keigi Fujiwara
Keigi Fujiwara The University of Texas MD Anderson Cancer Center
Jerrold R. Turner
Jerrold R. Turner Brigham and Women's Hospital
Vincent B. Young
Vincent B. Young University of Michigan–Ann Arbor

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