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Biology and Biochemistry

D-Index
85
Citations
18950
World Ranking
3222
National Ranking
1628

Overview

David J. Hackam is affiliated with Johns Hopkins University School of Medicine in the United States. Their research primarily spans the fields of medicine and nursing, with a strong focus on nutrition, respiratory health, surgery, immunology, and public health. The main subfields of study include nutrition and dietetics, pulmonary and respiratory medicine, surgery, immunology, and occupational health.

Their work covers several key topics such as infant nutrition and health, neonatal respiratory health research, clinical nutrition and gastroenterology, child nutrition and water access, breastfeeding practices and influences, COVID-19 clinical research studies, and immune response and inflammation.

David J. Hackam has contributed to numerous papers, including:

  • The human milk oligosaccharides 2'-fucosyllactose and 6'-sialyllactose protect against the development of necrotizing enterocolitis by inhibiting toll-like receptor 4 signaling (2020, Pediatric Research)
  • Bench to bedside - new insights into the pathogenesis of necrotizing enterocolitis (2022, Nature Reviews Gastroenterology & Hepatology)
  • Toll-like receptor 4-mediated enteric glia loss is critical for the development of necrotizing enterocolitis (2021, Science Translational Medicine)
  • Necrotizing enterocolitis, gut microbes, and sepsis (2023, Gut Microbes)
  • Necrotizing enterocolitis induces T lymphocyte-mediated injury in the developing mammalian brain (2021, Science Translational Medicine)

Their frequent coauthors include:

  • Chhinder P. Sodhi
  • Maame Efua Sampah
  • William B. Fulton
  • Sanasia Wang
  • Thomas Prindle

Their research has been published mainly in venues such as:

  • Pediatric Research
  • Gastroenterology
  • The Journal of Trauma: Injury, Infection, and Critical Care
  • Journal of the American College of Surgeons
  • Science Translational Medicine

Best Publications

  • Necrotizing enterocolitis: new insights into pathogenesis and mechanisms.

    Diego F. Niño;Chhinder P. Sodhi;David J. Hackam

  • A critical role for TLR4 in the pathogenesis of necrotizing enterocolitis by modulating intestinal injury and repair.

    Cynthia L. Leaphart;Jaime Cavallo;Steven C. Gribar;Selma Cetin

  • Enterocyte TLR4 Mediates Phagocytosis and Translocation of Bacteria Across the Intestinal Barrier

    Matthew D. Neal;Cynthia Leaphart;Ryan Levy;Jose Prince

  • Laparotomy versus Peritoneal Drainage for Necrotizing Enterocolitis and Perforation

    R. Lawrence Moss;Reed A. Dimmitt;Douglas C. Barnhart;Karl G. Sylvester

  • The iron transport protein NRAMP2 is an integral membrane glycoprotein that colocalizes with transferrin in recycling endosomes.

    Samantha Gruenheid;François Canonne-Hergaux;Susan Gauthier;David J. Hackam

  • Attenuation of pulmonary ACE2 activity impairs inactivation of des-Arg9 bradykinin/BKB1R axis and facilitates LPS-induced neutrophil infiltration.

    Chhinder P Sodhi;Christine Wohlford-Lenane;Yukihiro Yamaguchi;Thomas Prindle

  • Hemorrhagic Shock Induces NAD(P)H Oxidase Activation in Neutrophils: Role of HMGB1-TLR4 Signaling

    Jie Fan;Jie Fan;Yuehua Li;Ryan M. Levy;Janet J. Fan

  • Intestinal Epithelial Toll-Like Receptor 4 Regulates Goblet Cell Development and Is Required for Necrotizing Enterocolitis in Mice

    Chhinder P. Sodhi;Chhinder P. Sodhi;Matthew D. Neal;Matthew D. Neal;Richard Siggers;Richard Siggers;Shonan Sho;Shonan Sho

  • The role of the intestinal barrier in the pathogenesis of necrotizing enterocolitis.

    Rahul J. Anand;Cynthia L. Leaphart;Kevin P. Mollen;David J. Hackam

  • Reciprocal Expression and Signaling of TLR4 and TLR9 in the Pathogenesis and Treatment of Necrotizing Enterocolitis

    Steven C. Gribar;Chhinder P. Sodhi;Ward M. Richardson;Rahul J. Anand

  • Systemic inflammation and remote organ injury following trauma require HMGB1

    Ryan M Levy;Kevin Patrick Mollen;Jose M Prince;David J Kaczorowski

  • Host Resistance to Intracellular Infection: Mutation of Natural Resistance-associated Macrophage Protein 1 (Nramp1) Impairs Phagosomal Acidification

    David J. Hackam;Ori D. Rotstein;Wei Jian Zhang;Samantha Gruenheid

  • Breast milk protects against the development of necrotizing enterocolitis through inhibition of Toll Like Receptor 4 in the intestinal epithelium via activation of the epidermal growth factor receptor

    Misty Good;Chhinder P. Sodhi;Charlotte E. Egan;Amin Afrazi

  • Endothelial TLR4 activation impairs intestinal microcirculatory perfusion in necrotizing enterocolitis via eNOS-NO-nitrite signaling.

    Ibrahim Yazji;Chhinder P. Sodhi;Elizabeth K. Lee;Misty Good

  • Toll-Like Receptor-4 Inhibits Enterocyte Proliferation via Impaired β-Catenin Signaling in Necrotizing Enterocolitis

    Chhinder P. Sodhi;Xia–Hua Shi;Ward M. Richardson;Zachary S. Grant

  • The role of epithelial Toll-like receptor signaling in the pathogenesis of intestinal inflammation

    Steven C. Gribar;Rahul J. Anand;Chhinder P. Sodhi;David J. Hackam

  • Mechanism of decreased in vitro murine macrophage cytokine release after exposure to carbon dioxide: relevance to laparoscopic surgery.

    Michael A. West;David J. Hackam;Jeffrey Baker;Jorge L. Rodriguez

  • Toll-like receptor 4 is expressed on intestinal stem cells and regulates their proliferation and apoptosis via the p53 up-regulated modulator of apoptosis.

    Matthew D. Neal;Chhinder P. Sodhi;Hongpeng Jia;Mitchell Dyer

  • Toll-like receptor 4–mediated lymphocyte influx induces neonatal necrotizing enterocolitis

    Charlotte E. Egan;Chhinder P. Sodhi;Misty Good;Joyce Lin

  • Rho is Required for the Initiation of Calcium Signaling and Phagocytosis by Fcγ Receptors in Macrophages

    David J. Hackam;Ori D. Rotstein;Alan Schreiber;Wei Jian Zhang

Frequent Co-Authors

Chhinder P. Sodhi
Chhinder P. Sodhi Johns Hopkins University
Timothy R. Billiar
Timothy R. Billiar University of Pittsburgh
Ori D. Rotstein
Ori D. Rotstein University of Toronto
Peter Wipf
Peter Wipf University of Pittsburgh
Yoram Vodovotz
Yoram Vodovotz University of Pittsburgh
Simon C. Watkins
Simon C. Watkins University of Pittsburgh
Alan D. Schreiber
Alan D. Schreiber University of Pennsylvania
Kevin J. Tracey
Kevin J. Tracey Feinstein Institute for Medical Research
Donna B. Stolz
Donna B. Stolz University of Pittsburgh
Philippe Gros
Philippe Gros McGill University

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