D-Index & Metrics Best Publications

D-Index & Metrics

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 130 Citations 72,581 618 World Ranking 172 National Ranking 125
Medicine D-index 130 Citations 63,091 656 World Ranking 992 National Ranking 594

Overview

What is he best known for?

The fields of study he is best known for:

  • Internal medicine
  • Gene
  • Enzyme

Timothy R. Billiar mainly investigates Nitric oxide, Cell biology, Nitric oxide synthase, Molecular biology and Biochemistry. His research integrates issues of Apoptosis, Immunology and Pharmacology in his study of Nitric oxide. In his study, Innate immune system, Immune system, Pathology and Receptor is strongly linked to Inflammation, which falls under the umbrella field of Cell biology.

His studies in Nitric oxide synthase integrate themes in fields like Endothelial stem cell, Downregulation and upregulation, Knockout mouse, Regulation of gene expression and Cell type. His Molecular biology research incorporates themes from Tumor necrosis factor alpha, Cell culture, Gene expression, Gene and Cytokine. In his work, In vitro is strongly intertwined with In vivo, which is a subfield of Biochemistry.

His most cited work include:

  • Genomic responses in mouse models poorly mimic human inflammatory diseases (1987 citations)
  • The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion (926 citations)
  • Nitric oxide inhibits apoptosis by preventing increases in caspase-3-like activity via two distinct mechanisms. (823 citations)

What are the main themes of his work throughout his whole career to date?

Timothy R. Billiar mostly deals with Immunology, Nitric oxide, Inflammation, Cell biology and Internal medicine. His work deals with themes such as Molecular biology, Biochemistry, Pharmacology and Hepatocyte, which intersect with Nitric oxide. He has included themes like Tumor necrosis factor alpha and Downregulation and upregulation in his Molecular biology study.

His Inflammation study incorporates themes from Innate immune system, Lung injury and Pathology. His Cell biology study combines topics from a wide range of disciplines, such as Apoptosis and Lipopolysaccharide. His research in Internal medicine intersects with topics in Endocrinology, Surgery and Cardiology.

He most often published in these fields:

  • Immunology (23.24%)
  • Nitric oxide (23.93%)
  • Inflammation (21.19%)

What were the highlights of his more recent work (between 2015-2021)?

  • Inflammation (21.19%)
  • Immunology (23.24%)
  • Sepsis (8.59%)

In recent papers he was focusing on the following fields of study:

His primary areas of investigation include Inflammation, Immunology, Sepsis, Cell biology and Cancer research. His Inflammation study is concerned with the larger field of Internal medicine. In his study, Tumor necrosis factor alpha is strongly linked to Lung injury, which falls under the umbrella field of Immunology.

In his research, Hepatocyte is intimately related to HMGB1, which falls under the overarching field of Cell biology. His Cancer research research is multidisciplinary, incorporating elements of Apoptosis and Metastasis. His biological study deals with issues like Pharmacology, which deal with fields such as Proinflammatory cytokine.

Between 2015 and 2021, his most popular works were:

  • Prehospital Plasma during Air Medical Transport in Trauma Patients at Risk for Hemorrhagic Shock. (220 citations)
  • The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity (177 citations)
  • PKM2-Dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation (155 citations)

In his most recent research, the most cited papers focused on:

  • Internal medicine
  • Gene
  • Enzyme

Immunology, Inflammation, Cell biology, Sepsis and Injury Severity Score are his primary areas of study. His studies deal with areas such as Signal transduction and Lung injury as well as Immunology. His Inflammation research entails a greater understanding of Internal medicine.

His biological study spans a wide range of topics, including Pyroptosis, Inflammasome, Caspase-11, Lipopolysaccharide and HMGB1. His Lipopolysaccharide research is multidisciplinary, relying on both Interleukin and Pharmacology. His work focuses on many connections between Toll-like receptor and other disciplines, such as Electrophoretic mobility shift assay, that overlap with his field of interest in Molecular biology.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Genomic responses in mouse models poorly mimic human inflammatory diseases

Seok Junhee Seok;Shaw Warren H. Shaw Warren;G. Cuenca Alex;N. Mindrinos Michael.
Proceedings of the National Academy of Sciences of the United States of America (2013)

2457 Citations

The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion

Allan Tsung;Rohit Sahai;Hiroyuki Tanaka;Atsunori Nakao.
Journal of Experimental Medicine (2005)

1296 Citations

Inflammation, immunoregulation, and inducible nitric oxide synthase

Andreas K. Nussler;Timothy R. Billiar.
Journal of Leukocyte Biology (1993)

1127 Citations

Apoptosis induced in normal human hepatocytes by tumor necrosis factor-related apoptosis-inducing ligand

Minji Jo;Tae-Hyoung Kim;Dai-Wu Seol;James E. Esplen.
Nature Medicine (2000)

1081 Citations

Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes.

D A Geller;C J Lowenstein;R A Shapiro;A K Nussler.
Proceedings of the National Academy of Sciences of the United States of America (1993)

1055 Citations

Nitric oxide inhibits apoptosis by preventing increases in caspase-3-like activity via two distinct mechanisms.

Young-Myeong Kim;Robert V. Talanian;Timothy R. Billiar.
Journal of Biological Chemistry (1997)

1036 Citations

A genomic storm in critically injured humans

Wenzhong Xiao;Wenzhong Xiao;Michael N. Mindrinos;Junhee Seok;Joseph Cuschieri.
Journal of Experimental Medicine (2011)

940 Citations

New insights into the regulation of inducible nitric oxide synthesis

S. M. Morris;T. R. Billiar.
American Journal of Physiology-endocrinology and Metabolism (1994)

894 Citations

HMGB1: endogenous danger signaling.

John R. Klune;Rajeev Dhupar;Jon Cardinal;Timothy R. Billiar.
Molecular Medicine (2008)

838 Citations

Cytokines, endotoxin, and glucocorticoids regulate the expression of inducible nitric oxide synthase in hepatocytes.

D A Geller;A K Nussler;M Di Silvio;C J Lowenstein.
Proceedings of the National Academy of Sciences of the United States of America (1993)

831 Citations

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