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D-Index
168
Citations
107050
World Ranking
568
National Ranking
331

Overview

Timothy R. Billiar is affiliated with the University of Pittsburgh in the United States. Their research spans multiple fields, primarily within medicine, biochemistry, genetics, molecular biology, immunology, and microbiology. The subfields covered by their work include immunology, molecular biology, epidemiology, emergency medicine, and critical care and intensive care medicine.

Their research topics focus on the intersection of immune responses, trauma, and critical care, with particular attention to sepsis diagnosis and treatment, immune response and inflammation, trauma and emergency care studies, inflammasome and immune disorders, trauma-related hemostasis and coagulopathy management, the role of immune cells in cancer, and neutrophil-related oxidative mechanisms.

  • Sepsis Diagnosis and Treatment
  • Immune Response and Inflammation
  • Trauma and Emergency Care Studies
  • Inflammasome and Immune Disorders
  • Trauma, Hemostasis, Coagulopathy, Resuscitation
  • Immune Cells in Cancer
  • Neutrophil, Myeloperoxidase and Oxidative Mechanisms

Billiar has contributed extensively to science through numerous publications. Some recent papers include:

  • "Immune-Responsive Gene 1/Itaconate Activates Nuclear Factor Erythroid 2-Related Factor 2 in Hepatocytes to Protect Against Liver Ischemia-Reperfusion Injury" (2020) published in Hepatology
  • "TMEM173 Drives Lethal Coagulation in Sepsis" (2020) published in Cell Host & Microbe
  • "HMGB1 as a potential biomarker and therapeutic target for severe COVID-19" (2020) published in Heliyon
  • "Platelet TLR4-ERK5 Axis Facilitates NET-Mediated Capturing of Circulating Tumor Cells and Distant Metastasis after Surgical Stress" (2021) published in Cancer Research
  • "LPS Induces Active HMGB1 Release From Hepatocytes Into Exosomes Through the Coordinated Activities of TLR4 and Caspase-11/GSDMD Signaling" (2020) published in Frontiers in Immunology

The research venues where Billiar frequently publishes reflect the scope and reach of their scientific work. These include:

  • Frontiers in Immunology
  • The Journal of Trauma: Injury, Infection, and Critical Care
  • Shock
  • Journal of the American College of Surgeons
  • Research Square

Collaboration is a notable element in Billiar's body of work. Frequent coauthors who have contributed significantly alongside Billiar include:

  • Yoram Vodovotz
  • Jason L. Sperry
  • Matthew D. Neal
  • Rami A. Namas
  • Haichao Wang

Best Publications

  • Genomic responses in mouse models poorly mimic human inflammatory diseases

    Seok Junhee Seok;Shaw Warren H. Shaw Warren;G. Cuenca Alex;N. Mindrinos Michael

  • A network-based analysis of systemic inflammation in humans

    Steve E. Calvano;Wenzhong Xiao;Daniel R. Richards;Ramon M. Felciano

  • The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion

    Allan Tsung;Rohit Sahai;Hiroyuki Tanaka;Atsunori Nakao

  • A genomic storm in critically injured humans

    Wenzhong Xiao;Wenzhong Xiao;Michael N. Mindrinos;Junhee Seok;Joseph Cuschieri

  • Inflammation, immunoregulation, and inducible nitric oxide synthase

    Andreas K. Nussler;Timothy R. Billiar

  • Apoptosis induced in normal human hepatocytes by tumor necrosis factor-related apoptosis-inducing ligand

    Minji Jo;Tae-Hyoung Kim;Dai-Wu Seol;James E. Esplen

  • Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes.

    D A Geller;C J Lowenstein;R A Shapiro;A K Nussler

  • Nitric oxide inhibits apoptosis by preventing increases in caspase-3-like activity via two distinct mechanisms.

    Young-Myeong Kim;Robert V. Talanian;Timothy R. Billiar

  • HMGB1 in Health and Disease

    Rui Kang;Ruochan Chen;Qiuhong Zhang;Wen Hou

  • HMGB1: endogenous danger signaling.

    John R. Klune;Rajeev Dhupar;Jon Cardinal;Timothy R. Billiar

  • New insights into the regulation of inducible nitric oxide synthesis

    S. M. Morris;T. R. Billiar

  • Cytokines, endotoxin, and glucocorticoids regulate the expression of inducible nitric oxide synthase in hepatocytes.

    D A Geller;A K Nussler;M Di Silvio;C J Lowenstein

  • Nitrogen oxide levels in patients after trauma and during sepsis.

    Juan B. Ochoa;Anthony O. Udekwu;Timothy R. Billiar;Ronald D. Curran

  • The grateful dead: damage-associated molecular pattern molecules and reduction/oxidation regulate immunity.

    Michael T. Lotze;Herbert J. Zeh;Anna Rubartelli;Louis J. Sparvero

  • The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity

    Yangchun Xie;Yangchun Xie;Yangchun Xie;Shan Zhu;Xinxin Song;Xiaofang Sun

  • Prehospital Plasma during Air Medical Transport in Trauma Patients at Risk for Hemorrhagic Shock.

    Jason L. Sperry;Francis X. Guyette;Joshua B. Brown;Mark H. Yazer

  • Nitric oxide as a bioregulator of apoptosis.

    Hun-Taeg Chung;Hyun-Ock Pae;Byung-Min Choi;Byung-Min Choi;Timothy R. Billiar

  • HMGB1 release induced by liver ischemia involves Toll-like receptor 4–dependent reactive oxygen species production and calcium-mediated signaling

    Allan Tsung;John R. Klune;Xianghong Zhang;Geetha Jeyabalan

  • Nitric Oxide Protects Cultured Rat Hepatocytes from Tumor Necrosis Factor-α-induced Apoptosis by Inducing Heat Shock Protein 70 Expression

    Young-Myeong Kim;Michael E. de Vera;Simon C. Watkins;Timothy R. Billiar

  • Linking oxidative stress to inflammation: Toll-like receptors

    Roop Gill;Allan Tsung;Timothy R. Billiar

Frequent Co-Authors

Yoram Vodovotz
Yoram Vodovotz University of Pittsburgh
Andrew B. Peitzman
Andrew B. Peitzman University of Pittsburgh
David A. Geller
David A. Geller University of Pittsburgh
Jie Fan
Jie Fan University of Pittsburgh
Simon C. Watkins
Simon C. Watkins University of Pittsburgh
Mitchell P. Fink
Mitchell P. Fink University of California, Los Angeles
Michael T. Lotze
Michael T. Lotze University of Pittsburgh
Kenneth R. McCurry
Kenneth R. McCurry Cleveland Clinic
Young-Myeong Kim
Young-Myeong Kim Kangwon National University
David J. Hackam
David J. Hackam Johns Hopkins University School of Medicine

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