World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
92
Citations
33621
World Ranking
2203
National Ranking
1190

Medicine

D-Index
93
Citations
33835
World Ranking
10835
National Ranking
5577

Overview

Leo E. Otterbein is affiliated with Beth Israel Deaconess Medical Center in the United States. Their research spans multiple fields including Medicine, Biochemistry, Genetics and Molecular Biology, and Immunology and Microbiology. Subfields of focus include Molecular Biology, Immunology, Pediatrics, Perinatology and Child Health, Epidemiology, and Pharmacology.

The scientist's work encompasses a range of topics such as:

  • Heme Oxygenase-1 and Carbon Monoxide
  • Neonatal Health and Biochemistry
  • Immune Response and Inflammation
  • Immune cells in cancer
  • Cannabis and Cannabinoid Research
  • Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Optimism, Hope, and Well-being

Frequent co-authors in Otterbein's publications include:

  • Carl J. Hauser
  • David Gallo
  • Eva Csizmadia
  • Rodrigo Wagner Alves de Souza
  • James D. Byrne

They have contributed to a variety of publication venues with multiple entries in:

  • The Journal of Trauma: Injury, Infection, and Critical Care
  • UNC Libraries
  • Advanced Science
  • Medicinal Research Reviews
  • Annals of Surgery

Recent significant papers authored or co-authored by Leo E. Otterbein include:

  • Carbon Monoxide: from Poison to Clinical Trials, 2021, Trends in Pharmacological Sciences
  • Delivery of therapeutic carbon monoxide by gas-entrapping materials, 2022, Science Translational Medicine
  • NO, CO and H2S: A trinacrium of bioactive gases in the brain, 2022, Biochemical Pharmacology
  • Adapting decarbonylation chemistry for the development of prodrugs capable of in vivo delivery of carbon monoxide utilizing sweeteners as carrier molecules, 2021, Chemical Science
  • Carbon monoxide and a change of heart, 2021, Redox Biology

Best Publications

  • Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway

    Leo E. Otterbein;Leo E. Otterbein;Fritz H. Bach;Jawed Alam;Miguel P. Soares

  • The therapeutic potential of carbon monoxide.

    Roberto Motterlini;Leo E. Otterbein

  • Heme oxygenase-1: unleashing the protective properties of heme

    Leo E. Otterbein;Miguel P. Soares;Kenichiro Yamashita;Fritz H. Bach

  • Carbon monoxide generated by heme oxygenase 1 suppresses endothelial cell apoptosis.

    Sophie Brouard;Leo E. Otterbein;Josef Anrather;Edda Tobiasch

  • Heme oxygenase: colors of defense against cellular stress

    Leo E. Otterbein;Augustine M. K. Choi;Augustine M. K. Choi

  • The sedoheptulose kinase CARKL directs macrophage polarization through control of glucose metabolism

    Arvand Haschemi;Arvand Haschemi;Paul Kosma;Lars Gille;Charles R. Evans

  • Carbon monoxide suppresses arteriosclerotic lesions associated with chronic graft rejection and with balloon injury

    Leo E Otterbein;Brian S Zuckerbraun;Manabu Haga;Fang Liu

  • Heme oxygenase/carbon monoxide signaling pathways: regulation and functional significance.

    Stefan W. Ryter;Leo E. Otterbein;Danielle Morse;Augustine M. K. Choi

  • Exogenous administration of heme oxygenase-1 by gene transfer provides protection against hyperoxia-induced lung injury

    Leo E. Otterbein;Jay K. Kolls;Lin L. Mantell;Julia L. Cook

  • Carbon monoxide provides protection against hyperoxic lung injury.

    Leo E. Otterbein;Leo E. Otterbein;Leo E. Otterbein;Lin L. Mantell;Augustine M. K. Choi;Augustine M. K. Choi

  • Carbon Monoxide Generated by Heme Oxygenase-1 Suppresses the Rejection of Mouse-to-Rat Cardiac Transplants

    K. Sato;J. Balla;L. Otterbein;R. N. Smith

  • Carbon monoxide in biology and medicine

    Stefan W. Ryter;Leo E. Otterbein

  • Suppression of Inflammatory Cytokine Production by Carbon Monoxide Involves the JNK Pathway and AP-1

    Danielle Morse;Soeren E. Pischke;Zhihong Zhou;Roger J. Davis

  • Heme oxygenase-1 inhibits TNF-α-induced apoptosis in cultured fibroblasts

    Irina Petrache;Leo E. Otterbein;Leo E. Otterbein;Jawed Alam;Gordon W. Wiegand

  • Metabolic control of type 1 regulatory T cell differentiation by AHR and HIF1-α

    Ivan D Mascanfroni;Maisa C Takenaka;Ada Yeste;Bonny Patel

  • Hemoglobin provides protection against lethal endotoxemia in rats: the role of heme oxygenase-1.

    Leo Otterbein;Sherrie L. Sylvester;Augustine M. K. Choi

  • Autoantibodies in patients with chronic obstructive pulmonary disease.

    Carol A. Feghali-Bostwick;Aneal S. Gadgil;Leo E. Otterbein;Joseph M. Pilewski

  • Carbon Monoxide Expedites Metabolic Exhaustion to Inhibit Tumor Growth

    Barbara Wegiel;David Gallo;Eva Csizmadia;Clair Harris

  • Carbon monoxide inhibition of apoptosis during ischemia-reperfusion lung injury is dependent on the p38 mitogen-activated protein kinase pathway and involves caspase 3.

    Xuchen Zhang;Peiying Shan;Leo E. Otterbein;Jawed Alam

  • Carbon monoxide signals via inhibition of cytochrome c oxidase and generation of mitochondrial reactive oxygen species

    Brian S. Zuckerbraun;Beek Yoke Chin;Martin Bilban;Joana de Costa d'Avila

Frequent Co-Authors

Augustine M. K. Choi
Augustine M. K. Choi Cornell University
Fritz H. Bach
Fritz H. Bach Harvard Medical School
Miguel P. Soares
Miguel P. Soares Instituto Gulbenkian de Ciência
Timothy R. Billiar
Timothy R. Billiar University of Pittsburgh
Simon C. Robson
Simon C. Robson Beth Israel Deaconess Medical Center
Anthony J. Bauer
Anthony J. Bauer Liberty University
Martin Bilban
Martin Bilban Medical University of Vienna
David A. Gallo
David A. Gallo University of Chicago
Noriko Murase
Noriko Murase University of Pittsburgh
Patty J. Lee
Patty J. Lee Duke University

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