World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
80
Citations
22272
World Ranking
4093
National Ranking
2011

Overview

Mark A. Perrella is affiliated with Brigham and Women's Hospital in the United States. Their research spans extensively across the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with notable contributions in Molecular Biology, Pulmonary and Respiratory Medicine, Immunology, Physiology, and Genetics.

The scientist's recent scholarly output includes multiple articles published between 2021 and 2024. Key recent papers are:

  • "Safety, tolerability, and efficacy of pirfenidone in patients with rheumatoid arthritis-associated interstitial lung disease: a randomised, double-blind, placebo-controlled, phase 2 study" (2022) in The Lancet Respiratory Medicine
  • "Inflammasome activation in neutrophils of patients with severe COVID-19" (2022) in Blood Advances
  • "Activation of CD8+ T Cells in Chronic Obstructive Pulmonary Disease Lung" (2023) in American Journal of Respiratory and Critical Care Medicine
  • "CD148 Deficiency in Fibroblasts Promotes the Development of Pulmonary Fibrosis" (2021) in American Journal of Respiratory and Critical Care Medicine
  • "A metabolomics pipeline highlights microbial metabolism in bloodstream infections" (2024) in Cell

Frequent coauthors collaborating with Mark A. Perrella include:

  • Xiaoli Liu
  • Souheil El-Chemaly
  • Julie Ng
  • Iván O. Rosas
  • James A. Lederer

The scientist's work has appeared in a variety of publication venues, showing a pattern of repeated contributions. Common venues include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Stem Cell Research & Therapy
  • Blood Advances
  • American Journal of Respiratory and Critical Care Medicine
  • FEBS Journal

The research themes covered by Mark A. Perrella can be summarized by these main topics:

  • Neonatal Respiratory Health Research
  • Mesenchymal stem cell research
  • Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
  • Tuberous Sclerosis Complex Research
  • Immune cells in cancer
  • Cellular transport and secretion
  • Congenital heart defects research

This combination of fields, topics, and collaborations indicates a strong focus on pulmonary and respiratory disorders with molecular and immunological approaches, alongside work in stem cell and genetic research areas.

Best Publications

  • Promotion of vascular smooth muscle cell growth by homocysteine: a link to atherosclerosis

    J C Tsai;M A Perrella;M Yoshizumi;C M Hsieh

  • Tumor necrosis factor downregulates an endothelial nitric oxide synthase mRNA by shortening its half-life.

    Masao Yoshizumi;Mark A. Perrella;John C. Burnett;Mu En Lee

  • SMOOTH MUSCLE CELL-DERIVED CARBON MONOXIDE IS A REGULATOR OF VASCULAR CGMP

    Toshisuke Morita;Mark A. Perrella;Mu-En Lee;Stella Kourembanas

  • Natriuretic peptide system in human heart failure.

    Chi Ming Wei;Denise M. Heublein;Mark A. Perrella;Amir Lerman

  • Cardiac-Specific Expression of Heme Oxygenase-1 Protects Against Ischemia and Reperfusion Injury in Transgenic Mice

    Shaw Fang Yet;Rong Tian;Matthew D. Layne;Zhi Yuan Wang

  • Lipoxin A4 Regulates Natural Killer Cell and Type 2 Innate Lymphoid Cell Activation in Asthma

    Cindy Barnig;Manuela Cernadas;Stefanie Dutile;Xiaoli Liu

  • Hypoxia induces severe right ventricular dilatation and infarction in heme oxygenase-1 null mice.

    Shaw-Fang Yet;Mark A. Perrella;Matthew D. Layne;Chung-Ming Hsieh

  • Induction of Vascular Endothelial Growth Factor Gene Expression by Interleukin-1 β in Rat Aortic Smooth Muscle Cells (∗)

    Jian Li;Mark A. Perrella;Mark A. Perrella;Jer-Chia Tsai;Shaw-Fang Yet

  • Targeted expression of heme oxygenase-1 prevents the pulmonary inflammatory and vascular responses to hypoxia

    Tohru Minamino;Helen Christou;Chung Ming Hsieh;Yuxiang Liu

  • Evidence for Human Lung Stem Cells

    Jan Kajstura;Marcello Rota;Sean R Hall;Toru Hosoda

  • Gene Therapy Strategy for Long-Term Myocardial Protection Using Adeno-Associated Virus-Mediated Delivery of Heme Oxygenase Gene

    Luis G. Melo;Reitu Agrawal;Lunan Zhang;Mojgan Rezvani

  • Akt participation in the Wnt signaling pathway through Dishevelled.

    Shinya Fukumoto;Chung-Ming Hsieh;Koji Maemura;Matthew D. Layne

  • Enhanced inhibition of neointimal hyperplasia by genetically engineered endothelial progenitor cells.

    Deling Kong;Luis G. Melo;Abeel A. Mangi;Lunan Zhang

  • Heme oxygenase-1–derived carbon monoxide enhances the host defense response to microbial sepsis in mice

    Su Wol Chung;Xiaoli Liu;Alvaro A. Macias;Rebecca M. Baron

  • Absence of heme oxygenase-1 exacerbates atherosclerotic lesion formation and vascular remodeling

    Shaw Fang Yet;Matthew D. Layne;Xiaoli Liu;Yen Hsu Chen;Yen Hsu Chen

  • Inhibition of Growth and p21ras Methylation in Vascular Endothelial Cells by Homocysteine but Not Cysteine

    Hong Wang;Masao Yoshizumi;Kaihua Lai;Jer-Chia Tsai

  • Induction of cyclin A gene expression by homocysteine in vascular smooth muscle cells

    Jer Chia Tsai;Hong Wang;Mark A. Perrella;Masao Yoshizumi

  • Heme Oxygenase-1 A Novel Drug Target for Atherosclerotic Diseases?

    Roland Stocker;Mark A. Perrella

  • Induction of heme oxygenase-1 expression in vascular smooth muscle cells. A link to endotoxic shock

    Shaw Fang Yet;Andrea Pellacani;Cam Patterson;Larissa Tan

  • Induction of Apoptosis by Pyrrolidinedithiocarbamate and N-Acetylcysteine in Vascular Smooth Muscle Cells (∗)

    Jer Chia Tsai;Mukesh Jain;Chung Ming Hsieh;Wen Sen Lee

Frequent Co-Authors

Mu-En Lee
Mu-En Lee Harvard University
Shaw-Fang Yet
Shaw-Fang Yet National Health Research Institutes
Chung-Ming Hsieh
Chung-Ming Hsieh MSD (United States)
Edgar Haber
Edgar Haber Harvard University
Mukesh K. Jain
Mukesh K. Jain Brown University
Augustine M. K. Choi
Augustine M. K. Choi Cornell University
Piero Anversa
Piero Anversa Brigham and Women's Hospital
John C. Burnett
John C. Burnett Mayo Clinic
Annarosa Leri
Annarosa Leri Brigham and Women's Hospital
Wen Sen Lee
Wen Sen Lee Taipei Medical University

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