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Best Scientists

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Medicine

D-Index
168
Citations
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World Ranking
564
National Ranking
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Research.com Recognitions

  • 2014 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 2013 - Fellow of the American Academy of Arts and Sciences
  • 2006 - Member of the National Academy of Medicine (NAM)
  • 2004 - Distinguished Scientist Award, American Heart Association
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

Joseph Loscalzo is affiliated with Harvard Medical School in the United States. Their research primarily spans the fields of biochemistry, genetics, and molecular biology, with significant involvement in medicine. Within these areas, they focus substantially on molecular biology, computational theory and mathematics, pulmonary and respiratory medicine, cardiology and cardiovascular medicine, and genetics.

Their work covers several key topics, including:

  • Bioinformatics and genomic networks
  • Computational drug discovery methods
  • Metabolomics and mass spectrometry studies
  • Pulmonary hypertension research and treatments
  • Single-cell and spatial transcriptomics
  • Cancer, hypoxia, and metabolism
  • Gene regulatory network analysis

Joseph Loscalzo has contributed to multiple publication venues, appearing frequently in:

  • New England Journal of Medicine
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Circulation
  • Nature Communications
  • Circulation Research

Recent papers authored by them include:

  • Network medicine framework for identifying drug-repurposing opportunities for COVID-19, 2021, PubMed Central
  • COVID-19 and Cardiovascular Disease, 2021, Circulation Research
  • Target identification among known drugs by deep learning from heterogeneous networks, 2020, Chemical Science
  • Comprehensive characterization of protein-protein interactions perturbed by disease mutations, 2021, Nature Genetics
  • The role of glutathione peroxidase-1 in health and disease, 2022, Free Radical Biology and Medicine

Frequent collaborators in their research include Rui-Sheng Wang, Bradley A. Maron, Albert-László Barabási, William M. Oldham, and Jan Baumbach.

Joseph Loscalzo's accolades encompass several honors, such as:

  • Fellow of the American Association for the Advancement of Science (AAAS), 2014
  • Fellow of the American Academy of Arts and Sciences, 2013
  • Member of the National Academy of Medicine (NAM), 2006
  • Distinguished Scientist Award, American Heart Association, 2004
  • Member of the Association of American Physicians

Best Publications

  • Network Medicine: A Network-Based Approach to Human Disease

    Albert-László Barabási;Natali Gulbahce;Natali Gulbahce;Natali Gulbahce;Joseph Loscalzo

  • Endothelial Cells in Physiology and in the Pathophysiology of Vascular Disorders

    Douglas B. Cines;Eleanor S. Pollak;Clayton A. Buck;Joseph Loscalzo

  • Biochemistry of nitric oxide and its redox-activated forms

    Jonathan S. Stamler;David J. Singel;Joseph Loscalzo

  • A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds

    Stuart A. Lipton;Yun-Beom Choi;Yun-Beom Choi;Zhuo-Hua Pan;Zhuo-Hua Pan;Sizheng Z. Lei;Sizheng Z. Lei

  • Homocysteine and atherothrombosis

    George N. Welch;Joseph Loscalzo

  • Pulmonary arterial hypertension.

    Harrison W Farber;Joseph Loscalzo

  • Uncovering disease-disease relationships through the incomplete interactome

    Jörg Menche;Amitabh Sharma;Maksim Kitsak;Maksim Kitsak;Susan Dina Ghiassian;Susan Dina Ghiassian

  • Impaired vasodilation of forearm resistance vessels in hypercholesterolemic humans.

    Mark A. Creager;John P. Cooke;Michael E. Mendelsohn;Shelly J. Gallagher

  • Glutathione Peroxidase-1 in Health and Disease: From Molecular Mechanisms to Therapeutic Opportunities

    Edith Lubos;Joseph Loscalzo;Diane E. Handy

  • Adverse vascular effects of homocysteine are modulated by endothelium-derived relaxing factor and related oxides of nitrogen.

    Jonathan S. Stamler;John A. Osborne;Omar Jaraki;Leroy E. Rabbani

  • The biology of nitrogen oxides in the airways

    B. Gaston;J. M. Drazen;J. Loscalzo;J. S. Stamler

  • Vascular Calcification Pathobiological Mechanisms and Clinical Implications

    Rebecca C. Johnson;Jane A. Leopold;Joseph Loscalzo

  • The oxidant stress of hyperhomocyst(e)inemia.

    J Loscalzo

  • Epigenetic Modifications Basic Mechanisms and Role in Cardiovascular Disease

    Diane E. Handy;Rita Castro;Joseph Loscalzo

  • Homocyst(e)ine decreases bioavailable nitric oxide by a mechanism involving glutathione peroxidase

    Gilbert R. Upchurch;George N. Welch;Attila J. Fabian;Jane E. Freedman

  • Nitric oxide and its role in the cardiovascular system.

    Joseph Loscalzo;George Welch

  • In vivo tracking of platelets: circulating degranulated platelets rapidly lose surface P-selectin but continue to circulate and function

    A D Michelson;M R Barnard;H B Hechtman;H MacGregor

  • Genetic Misdiagnoses and the Potential for Health Disparities

    Arjun K. Manrai;Birgit H. Funke;Heidi L. Rehm;Morten S. Olesen

  • Nitric Oxide Insufficiency, Platelet Activation, and Arterial Thrombosis

    Joseph Loscalzo

  • Flow activates an endothelial potassium channel to release an endogenous nitrovasodilator.

    John P. Cooke;Eugene Rossitch;Nancy A. Andon;Joseph Loscalzo

Frequent Co-Authors

Jonathan S. Stamler
Jonathan S. Stamler Case Western Reserve University
Diane E. Handy
Diane E. Handy Brigham and Women's Hospital
Albert-László Barabási
Albert-László Barabási Northeastern University
Jane E. Freedman
Jane E. Freedman Vanderbilt University Medical Center
Joseph A. Vita
Joseph A. Vita Boston University
Bruce D. Levy
Bruce D. Levy Brigham and Women's Hospital
John F. Keaney
John F. Keaney Brigham and Women's Hospital
Edwin K. Silverman
Edwin K. Silverman Brigham and Women's Hospital
Calum A. MacRae
Calum A. MacRae Brigham and Women's Hospital
Isaac S. Kohane
Isaac S. Kohane Harvard University

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