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Overview

Calum A. MacRae is affiliated with Brigham and Women's Hospital in the United States. Their research primarily spans the fields of Medicine and Biochemistry, Genetics, and Molecular Biology, with extensive work in Molecular Biology, Cardiology and Cardiovascular Medicine, Genetics, Cell Biology, and Physiology.

The primary focus of MacRae's work involves several key topics, including:

  • Cardiomyopathy and Myosin Studies
  • Cardiac electrophysiology and arrhythmias
  • Cardiovascular Function and Risk Factors
  • Congenital heart defects research
  • Nuclear Structure and Function
  • CRISPR and Genetic Engineering
  • Erythrocyte Function and Pathophysiology

MacRae has contributed to numerous scientific papers, some of which include:

  • Artificial intelligence-enabled fully automated detection of cardiac amyloidosis using electrocardiograms and echocardiograms, 2021, Nature Communications
  • Valsartan in early-stage hypertrophic cardiomyopathy: a randomized phase 2 trial, 2021, Nature Medicine
  • Remote Optimization of Guideline-Directed Medical Therapy in Patients With Heart Failure With Reduced Ejection Fraction, 2020, JAMA Cardiology
  • Multinational Federated Learning Approach to Train ECG and Echocardiogram Models for Hypertrophic Cardiomyopathy Detection, 2022, Circulation
  • MIC-Drop: A platform for large-scale in vivo CRISPR screens, 2021, Science

The frequent venues where MacRae publishes reflect their interdisciplinary focus, with multiple publications in:

  • Circulation
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Genetics in Medicine
  • European Heart Journal
  • Circulation Research

Collaboration plays a significant role in MacRae's research activities. Frequent co-authors include:

  • Rahul C. Deo
  • Shinichi Goto
  • Manu Beerens
  • David Y. Chiang
  • Ryuichiro Yagi

Best Publications

  • Missense mutations in the rod domain of the lamin A/C gene as causes of dilated cardiomyopathy and conduction-system disease.

    Diane Fatkin;Calum MacRae;Takeshi Sasaki;Matthew R. Wolff

  • Alpha-tropomyosin and cardiac troponin T mutations cause familial hypertrophic cardiomyopathy: a disease of the sarcomere.

    Ludwig Thierfelder;Ludwig Thierfelder;Hugh Watkins;Hugh Watkins;Calum MacRae;Calum MacRae;Roger Lamas

  • Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants.

    Sekar Kathiresan;Benjamin F Voight;Shaun Purcell;Kiran Musunuru

  • Zebrafish as tools for drug discovery

    Calum A. MacRae;Randall T. Peterson

  • Primary contribution to zebrafish heart regeneration by gata4+ cardiomyocytes

    Kazu Kikuchi;Jennifer E. Holdway;Andreas A. Werdich;Ryan M. Anderson

  • Variants conferring risk of atrial fibrillation on chromosome 4q25

    Daniel F Gudbjartsson;David O Arnar;Anna Helgadottir;Solveig Gretarsdottir

  • Mutations in the desmosomal protein plakophilin-2 are common in arrhythmogenic right ventricular cardiomyopathy

    Brenda Gerull;Brenda Gerull;Arnd Heuser;Arnd Heuser;Thomas Wichter;Matthias Paul

  • Mutations in the cardiac myosin binding protein-C gene on chromosome 11 cause familial hypertrophic cardiomyopathy.

    Hugh Watkins;Hugh Watkins;David Conner;Ludwig Thierfelder;John A. Jarcho

  • Utility of Amino-Terminal Pro-Brain Natriuretic Peptide, Galectin-3, and Apelin for the Evaluation of Patients With Acute Heart Failure

    Roland R. van Kimmenade;James L. Januzzi;Patrick T. Ellinor;Umesh C. Sharma

  • RBM20, a gene for hereditary cardiomyopathy, regulates titin splicing

    Wei Guo;Sebastian Schafer;Marion L Greaser;Michael H Radke

  • Rapid behavior-based identification of neuroactive small molecules in the zebrafish

    David Kokel;Jennifer Bryan;Christian Laggner;Rick White

  • Common variants in KCNN3 are associated with lone atrial fibrillation

    Patrick T. Ellinor;Kathryn L. Lunetta;Kathryn L. Lunetta;Nicole L. Glazer;Arne Pfeufer

  • Drugs That Induce Repolarization Abnormalities Cause Bradycardia in Zebrafish

    David J. Milan;Travis A. Peterson;Jeremy N. Ruskin;Randall T. Peterson

  • Chemical suppression of a genetic mutation in a zebrafish model of aortic coarctation.

    Randall T Peterson;Stanley Y Shaw;Stanley Y Shaw;Travis A Peterson;David J Milan

  • High-throughput assay for small molecules that modulate zebrafish embryonic heart rate

    C Geoffrey Burns;David J Milan;Eric J Grande;Eric J Grande;Wolfgang Rottbauer;Wolfgang Rottbauer

  • C/EBPβ controls exercise-induced cardiac growth and protects against pathological cardiac remodeling

    Pontus Boström;Nina Mann;Jun Wu;Pablo A. Quintero

  • The regenerative capacity of zebrafish reverses cardiac failure caused by genetic cardiomyocyte depletion

    Jinhu Wang;Daniela Panáková;Kazu Kikuchi;Jennifer E. Holdway

  • Klf2 Is an Essential Regulator of Vascular Hemodynamic Forces In Vivo

    John S. Lee;Qing Yu;Jordan T. Shin;Eric Sebzda

  • Familial aggregation in lone atrial fibrillation.

    Patrick T. Ellinor;Danita M. Yoerger;Jeremy N. Ruskin;Calum A. MacRae

  • Risk stratification in the long-QT syndrome.

    Patrick T Ellinor;David J Milan;Calum A MacRae

Frequent Co-Authors

Christine E. Seidman
Christine E. Seidman Harvard University
Patrick T. Ellinor
Patrick T. Ellinor Harvard University
Randall T. Peterson
Randall T. Peterson University of Utah
David J. Milan
David J. Milan Fondation Leducq
Joseph Loscalzo
Joseph Loscalzo Harvard Medical School
Isaac S. Kohane
Isaac S. Kohane Harvard University
Jonathan G. Seidman
Jonathan G. Seidman Harvard University
Teri A. Manolio
Teri A. Manolio National Institutes of Health
Hugh Watkins
Hugh Watkins University of Oxford
Ingrid A. Holm
Ingrid A. Holm Boston Children's Hospital

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