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Peter B. Dirks

Peter B. Dirks

D-Index & Metrics

Medicine

D-Index
90
Citations
53190
World Ranking
11959
National Ranking
483

Overview

Peter B. Dirks is affiliated with the University of Toronto in Canada. Their research spans extensive areas within medicine and molecular biology, with significant contributions to biochemistry, genetics, and various neurological and cancer-related fields.

Dirks's main fields of study include:

  • Medicine
  • Biochemistry, Genetics and Molecular Biology

In terms of specialized subfields, their work covers:

  • Molecular Biology
  • Genetics
  • Neurology
  • Cancer Research
  • Pulmonary and Respiratory Medicine

The core topics explored by Dirks focus on:

  • Glioma Diagnosis and Treatment
  • Neuroblastoma Research and Treatments
  • Epigenetics and DNA Methylation
  • Single-cell and spatial transcriptomics
  • MicroRNA in disease regulation
  • Cancer Genomics and Diagnostics
  • Moyamoya disease diagnosis and treatment

Among their recent notable publications are:

  • "Integrated Molecular and Clinical Analysis of 1,000 Pediatric Low-Grade Gliomas," 2020, Cancer Cell
  • "Roadmap for the Emerging Field of Cancer Neuroscience," 2020, Cell
  • "Gradient of Developmental and Injury Response transcriptional states defines functional vulnerabilities underpinning glioblastoma heterogeneity," 2021, Nature Cancer
  • "GLUT1 inhibition blocks growth of RB1-positive triple negative breast cancer," 2020, Nature Communications
  • "PRMT5 inhibition disrupts splicing and stemness in glioblastoma," 2021, Nature Communications

Dirks frequently collaborates with other researchers. Their most frequent co-authors include:

  • Uri Tabori
  • Michael D. Taylor
  • Éric Bouffet
  • Vijay Ramaswamy
  • Cynthia Hawkins

Their research has been published predominantly in the following venues:

  • Neuro-Oncology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Journal of Neuro-Oncology
  • Nature

Best Publications

  • Identification of human brain tumour initiating cells

    Sheila K. Singh;Cynthia Hawkins;Ian D. Clarke;Jeremy A. Squire

  • Identification of a Cancer Stem Cell in Human Brain Tumors

    Sheila K. Singh;Ian D. Clarke;Mizuhiko Terasaki;Victoria E. Bonn

  • Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells.

    Michael F. Clarke;John E. Dick;Peter B. Dirks;Connie J. Eaves

  • High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities

    Traver Hart;Megha Chandrashekhar;Michael Aregger;Zachary Steinhart

  • Cancer stem cells: an evolving concept

    Long V. Nguyen;Robert Vanner;Peter Dirks;Connie J. Eaves

  • Intertumoral Heterogeneity within Medulloblastoma Subgroups

    Florence M.G. Cavalli;Marc Remke;Marc Remke;Marc Remke;Ladislav Rampasek;John Peacock

  • Glioma stem cell lines expanded in adherent culture have tumor-specific phenotypes and are suitable for chemical and genetic screens.

    Steven M. Pollard;Koichi Yoshikawa;Ian D. Clarke;Davide Danovi

  • Tumour-initiating cells: challenges and opportunities for anticancer drug discovery

    Bin-Bing S. Zhou;Haiying Zhang;Marc Damelin;Kenneth G. Geles

  • Subgroup-specific structural variation across 1,000 medulloblastoma genomes

    Paul A. Northcott;Paul A. Northcott;David J.H. Shih;John Peacock;Livia Garzia

  • Cancer stem cells in nervous system tumors.

    Sheila K Singh;Ian D Clarke;Takuichiro Hide;Peter B Dirks

  • Immune Checkpoint Inhibition for Hypermutant Glioblastoma Multiforme Resulting From Germline Biallelic Mismatch Repair Deficiency

    Eric Bouffet;Valérie Larouche;Brittany B. Campbell;Daniele Merico

  • Hypothermia Therapy after Traumatic Brain Injury in Children

    James S. Hutchison;Roxanne E. Ward;Jacques Lacroix;Paul C. Hébert

  • Comprehensive Analysis of Hypermutation in Human Cancer

    Brittany B. Campbell;Nicholas Light;David Fabrizio;Matthew Zatzman

  • Epigenomic alterations define lethal CIMP-positive ependymomas of infancy

    S. C. Mack;H. Witt;R. M. Piro;L. Gu

  • Integrated Molecular and Clinical Analysis of 1,000 Pediatric Low-Grade Gliomas.

    Scott Ryall;Michal Zapotocky;Kohei Fukuoka;Liana Nobre

  • Single cell-derived clonal analysis of human glioblastoma links functional and genomic heterogeneity.

    Mona Meyer;Jüri Reimand;Xiaoyang Lan;Renee Head

  • Fate mapping of human glioblastoma reveals an invariant stem cell hierarchy

    Xiaoyang Lan;David J. Jörg;Florence M. G. Cavalli;Laura M. Richards;Laura M. Richards

  • Divergent clonal selection dominates medulloblastoma at recurrence

    A. Sorana Morrissy;Livia Garzia;David J.H. Shih;Scott Zuyderduyn

  • Combined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated cancers.

    Adam Shlien;Brittany B Campbell;Richard de Borja;Ludmil B Alexandrov

  • Childhood cerebellar tumours mirror conserved fetal transcriptional programs

    Maria C. Vladoiu;Ibrahim El-Hamamy;Ibrahim El-Hamamy;Laura K. Donovan;Hamza Farooq

Frequent Co-Authors

Michael D. Taylor
Michael D. Taylor University of Toronto
James T. Rutka
James T. Rutka University of Toronto
Cynthia Hawkins
Cynthia Hawkins University of Toronto
Eric Bouffet
Eric Bouffet University of Toronto
Uri Tabori
Uri Tabori University of Toronto
Vijay Ramaswamy
Vijay Ramaswamy University of Toronto
Mathieu Lupien
Mathieu Lupien Princess Margaret Cancer Centre
James M. Drake
James M. Drake University of Toronto
Nada Jabado
Nada Jabado McGill University
Marc Remke
Marc Remke German Cancer Research Center

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