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Biology and Biochemistry

D-Index
63
Citations
11041
World Ranking
10453
National Ranking
272

Overview

Dirk Jan Slotboom is affiliated with the University of Groningen in the Netherlands. Their research primarily focuses on the fields of Biochemistry, Genetics, and Molecular Biology, with a total of 94 publications in these areas.

The researcher's work extends into several subfields, including Molecular Biology with 57 publications, Biochemistry (17), Cellular and Molecular Neuroscience (10), Genetics (9), and Oncology (8). These subfields reflect a broad scope within life sciences and related biomedical research.

Key topics addressed in their research encompass:

  • Amino Acid Enzymes and Metabolism
  • Drug Transport and Resistance Mechanisms
  • Lipid Membrane Structure and Behavior
  • RNA and Protein Synthesis Mechanisms
  • Bacterial Genetics and Biotechnology
  • Mitochondrial Function and Pathology
  • Neuroscience and Neuropharmacology Research

Dirk Jan Slotboom has contributed to various publication venues, with frequent appearances in:

  • Nature Communications (8 publications)
  • Zenodo (CERN European Organization for Nuclear Research) (7 publications)
  • bioRxiv (Cold Spring Harbor Laboratory) (6 publications)
  • Communications Biology (4 publications)
  • eLife (4 publications)

Their recent publications include the following papers:

  • "Structural and functional diversity calls for a new classification of ABC transporters" (2020), FEBS Letters
  • "Elevator-type mechanisms of membrane transport" (2020), Biochemical Society Transactions
  • "Structural ensemble of a glutamate transporter homologue in lipid nanodisc environment" (2020), Nature Communications
  • "Rational design of ASCT2 inhibitors using an integrated experimental-computational approach" (2021), Proceedings of the National Academy of Sciences
  • "Biparatopic sybodies neutralize SARS-CoV-2 variants of concern and mitigate drug resistance" (2022), EMBO Reports

Collaborations feature several frequent co-authors, highlighting active partnerships within the scientific community. The most common co-authors include:

  • Albert Guskov (14 collaborations)
  • Cristina Paulino (11 collaborations)
  • Bert Poolman (10 collaborations)
  • Jan Rheinberger (9 collaborations)
  • Siewert J. Marrink (9 collaborations)

Best Publications

  • Tuning Escherichia coli for membrane protein overexpression

    Samuel Wagner;Mirjam M. Klepsch;Susan Schlegel;Ansgar Appel

  • A structural classification of substrate-binding proteins

    Ronnie P.-A. Berntsson;Sander H.J. Smits;Lutz Schmitt;Dirk-Jan Slotboom

  • Structural diversity of ABC transporters.

    Josy ter Beek;Albert Guskov;Dirk Jan Slotboom

  • Optimization of membrane protein overexpression and purification using GFP fusions

    David Drew;Mirjam Lerch;Edmund Kunji;Dirk-Jan Slotboom

  • A Novel Class of Modular Transporters for Vitamins in Prokaryotes

    Dmitry A. Rodionov;Dmitry A. Rodionov;Peter Hebbeln;Aymerick Eudes;Josy ter Beek

  • Structural and functional diversity calls for a new classification of ABC transporters.

    Christoph Thomas;Stephen G. Aller;Konstantinos Beis;Konstantinos Beis;Elisabeth P. Carpenter

  • Lactococcus lactis as host for overproduction of functional membrane proteins

    Edmund R.S. Kunji;Dirk Jan Slotboom;Bert Poolman

  • Quality control of overexpressed membrane proteins.

    Eric R. Geertsma;Maarten Groeneveld;Dirk-Jan Slotboom;Bert Poolman

  • Static light scattering to characterize membrane proteins in detergent solution

    Dirk Jan Slotboom;Ria H. Duurkens;Kees Olieman;Guus B. Erkens

  • Structural Features of the Glutamate Transporter Family

    Dirk Jan Slotboom;Wil N. Konings;Juke S. Lolkema

  • A scalable, GFP-based pipeline for membrane protein overexpression screening and purification

    David Drew;Dirk-Jan Slotboom;Giulia Friso;Torsten Reda

  • Optimizing Membrane Protein Overexpression in the Escherichia coli strain Lemo21(DE3)

    Susan Schlegel;John Lofblom;Chiara Lee;Anna Hjelm

  • A conserved serine-rich stretch in the glutamate transporter family forms a substrate-sensitive reentrant loop

    Dirk Jan Slotboom;Iwona Sobczak;Wil N. Konings;Juke S. Lolkema

  • The terminal oxidases of Paracoccus denitrificans

    Jan-Willem L. de Gier;Mathias Lübben;Willem N.M. Reijnders;Corinne A. Tipker

  • Unsynchronised subunit motion in single trimeric sodium-coupled aspartate transporters

    Guus B. Erkens;Inga Hänelt;Inga Hänelt;Joris M. H. Goudsmits;Dirk Jan Slotboom

  • Cryo-EM structure of the human neutral amino acid transporter ASCT2

    Alisa Garaeva;Gerrit Oostergetel;Cornelius Gati;Albert Guskov

  • The Insulin-like Growth Factor-I–mTOR Signaling Pathway Induces the Mitochondrial Pyrimidine Nucleotide Carrier to Promote Cell Growth

    Suzanne Floyd;Cedric Favre;Francesco M. Lasorsa;Madeline Leahy

  • Structural and mechanistic insights into prokaryotic energy-coupling factor transporters

    Dirk J. Slotboom

  • The structural basis of modularity in ECF-type ABC transporters

    Guus B. Erkens;Ronnie P-A Berntsson;Faizah Fulyani;Dosz-Majsnerowska Dosz-Majsnerowska

  • Conserved properties of hydrogenosomal and mitochondrial ADP/ATP carriers: a common origin for both organelles

    Mark van der Giezen;Dirk Jan Slotboom;David S. Horner;Patricia L. Dyal

Frequent Co-Authors

Bert Poolman
Bert Poolman University of Groningen
Jan-Willem de Gier
Jan-Willem de Gier Stockholm University
Edmund R. S. Kunji
Edmund R. S. Kunji University of Cambridge
Juke S. Lolkema
Juke S. Lolkema University of Groningen
Gert Zimmer
Gert Zimmer University of Bern
Wil N. Konings
Wil N. Konings University of Groningen
Birte Svensson
Birte Svensson Technical University of Denmark
Adriaan H. Stouthamer
Adriaan H. Stouthamer Vrije Universiteit Amsterdam
Antoine M. van Oijen
Antoine M. van Oijen Illawarra Health and Medical Research Institute
Dmitry A. Rodionov
Dmitry A. Rodionov Sanford Burnham Prebys Medical Discovery Institute

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