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Genetics

D-Index
70
Citations
18834
World Ranking
2270
National Ranking
77

Overview

Mathieu Lupien is a researcher affiliated with the Princess Margaret Cancer Centre in Canada. Their work primarily spans biochemistry, genetics, and molecular biology, with a significant focus on medicine. Lupien's research delves into various subfields including molecular biology, cancer research, pulmonary and respiratory medicine, hematology, and genetics.

Lupien's research themes center around several key topics in biomedical science. These include genomics and chromatin dynamics, cancer genomics and diagnostics, epigenetics and DNA methylation, RNA modifications in cancer, prostate cancer treatment and research, glioma diagnosis and treatment, and cancer-related gene regulation.

They have contributed to multiple publications in well-known venues. The most frequent publication outlets are:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Cancer Research
  • Nature Genetics
  • Cell Stem Cell

The scientist has co-authored extensively with several researchers, including Christopher Arlidge, Stanley Zhou, Alex Murison, John E. Dick, and C.H. Arrowsmith.

Some of Lupien's recent papers include the following notable works:

  • Gradient of Developmental and Injury Response transcriptional states defines functional vulnerabilities underpinning glioblastoma heterogeneity, 2021, Nature Cancer
  • GLUT1 inhibition blocks growth of RB1-positive triple negative breast cancer, 2020, Nature Communications
  • PRMT5 inhibition disrupts splicing and stemness in glioblastoma, 2021, Nature Communications
  • Pioneer of prostate cancer: past, present and the future of FOXA1, 2020, Protein & Cell
  • Epigenetic Switch-Induced Viral Mimicry Evasion in Chemotherapy-Resistant Breast Cancer, 2020, Cancer Discovery

Their work reflects a focused interest in understanding cancer mechanisms at the molecular and epigenetic levels, with a particular emphasis on cancer types such as glioblastoma, breast cancer, and prostate cancer. The research involves examining regulatory pathways, transcriptional states, and genomic alterations that contribute to cancer progression and treatment resistance.

Best Publications

  • FoxA1 Translates Epigenetic Signatures into Enhancer-Driven Lineage-Specific Transcription

    Mathieu Lupien;Jérôme Eeckhoute;Clifford A. Meyer;Qianben Wang

  • Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer

    Qianben Wang;Wei Li;Yong Zhang;Xin Yuan

  • Epigenomic alterations define lethal CIMP-positive ependymomas of infancy

    S. C. Mack;H. Witt;R. M. Piro;L. Gu

  • Genomic hallmarks of localized, non-indolent prostate cancer

    Michael Fraser;Veronica Y. Sabelnykova;Takafumi N. Yamaguchi;Lawrence E. Heisler

  • Nucleosome dynamics define transcriptional enhancers.

    Housheng Hansen He;Clifford A. Meyer;Hyunjin Shin;Shannon T. Bailey

  • Positive Cross-Regulatory Loop Ties GATA-3 to Estrogen Receptor α Expression in Breast Cancer

    Jérôme Eeckhoute;Erika Krasnickas Keeton;Mathieu Lupien;Susan A. Krum

  • Estrogen-Dependent Signaling in a Molecularly Distinct Subclass of Aggressive Prostate Cancer

    Sunita R. Setlur;Kirsten D. Mertz;Yujin Hoshida;Yujin Hoshida;Francesca Demichelis

  • Fate mapping of human glioblastoma reveals an invariant stem cell hierarchy

    Xiaoyang Lan;David J. Jörg;Florence M. G. Cavalli;Laura M. Richards;Laura M. Richards

  • Combinatorial effects of multiple enhancer variants in linkage disequilibrium dictate levels of gene expression to confer susceptibility to common traits.

    Olivia Corradin;Alina Saiakhova;Batool Akhtar-Zaidi;Lois Myeroff

  • Epigenomic enhancer profiling defines a signature of colon cancer

    Batool Akhtar-Zaidi;Batool Akhtar-Zaidi;Richard Cowper-Sal·lari;Olivia Corradin;Alina Saiakhova

  • Breast cancer risk–associated SNPs modulate the affinity of chromatin for FOXA1 and alter gene expression

    Richard Cowper-Sal·lari;Xiaoyang Zhang;Jason B Wright;Swneke D Bailey;Swneke D Bailey

  • A Myc enhancer cluster regulates normal and leukaemic haematopoietic stem cell hierarchies.

    Carsten Bahr;Carsten Bahr;Lisa von Paleske;Lisa von Paleske;Veli V. Uslu;Silvia Remeseiro

  • Risk SNP-Mediated Promoter-Enhancer Switching Drives Prostate Cancer through lncRNA PCAT19

    Junjie Tony Hua;Junjie Tony Hua;Musaddeque Ahmed;Haiyang Guo;Yuzhe Zhang;Yuzhe Zhang;Yuzhe Zhang

  • Intratumor DNA methylation heterogeneity reflects clonal evolution in aggressive prostate cancer

    David Brocks;Yassen Assenov;Sarah Minner;Olga Bogatyrova

  • Functional Enhancers Shape Extrachromosomal Oncogene Amplifications

    Andrew R. Morton;Nergiz Dogan-Artun;Zachary J. Faber;Graham MacLeod

  • PharmacoGx: an R package for analysis of large pharmacogenomic datasets

    Petr Smirnov;Zhaleh Safikhani;Nehme El-Hachem;Dong Wang

  • Epigenetic switch involved in activation of pioneer factor FOXA1-dependent enhancers

    Aurélien A. Sérandour;Stéphane Avner;Frédéric Percevault;Florence Demay

  • CARM1 regulates estrogen-stimulated breast cancer growth through up-regulation of E2F1.

    Seth Frietze;Mathieu Lupien;Pamela A. Silver;Myles Brown

  • Overexpression of activated murine Notch1 and Notch3 in transgenic mice blocks mammary gland development and induces mammary tumors.

    Chunyan Hu;Anne Diévart;Mathieu Lupien;Ezequiel Calvo

  • Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors

    Jonathon Torchia;Brian Golbourn;Shengrui Feng;Shengrui Feng;King Ching Ho

Frequent Co-Authors

Cheryl H. Arrowsmith
Cheryl H. Arrowsmith Structural Genomics Consortium
Benjamin Haibe-Kains
Benjamin Haibe-Kains Princess Margaret Cancer Centre
John E. Dick
John E. Dick Princess Margaret Cancer Centre
Myles Brown
Myles Brown Harvard University
Paul C. Boutros
Paul C. Boutros University of California, Los Angeles
Trevor J. Pugh
Trevor J. Pugh Princess Margaret Cancer Centre
Housheng Hansen He
Housheng Hansen He University of Toronto
Peter B. Dirks
Peter B. Dirks University of Toronto
Robert G. Bristow
Robert G. Bristow University of Manchester
Michael D. Taylor
Michael D. Taylor University of Toronto

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