World's Best Scientists 2026 revealed!
Matthew L. Freedman

Matthew L. Freedman

D-Index & Metrics

Genetics

D-Index
89
Citations
30627
World Ranking
1117
National Ranking
535

Medicine

D-Index
89
Citations
31684
World Ranking
12614
National Ranking
6450

Overview

Matthew L. Freedman is affiliated with Harvard University in the United States. Their research spans the fields of Biochemistry, Genetics and Molecular Biology, and Medicine, with a focus on several subfields including Molecular Biology, Pulmonary and Respiratory Medicine, Cancer Research, Oncology, and Genetics.

The scientist's work extensively covers multiple main topics, reflecting a concentrated interest in prostate and renal cancers as well as cancer genomics. The primary topics include:

  • Prostate Cancer Treatment and Research
  • Epigenetics and DNA Methylation
  • Cancer Genomics and Diagnostics
  • Renal cell carcinoma treatment
  • Genomics and Chromatin Dynamics
  • Genetic Associations and Epidemiology
  • PARP inhibition in cancer therapy

Matthew L. Freedman has co-authored with several frequent collaborators, indicating ongoing research partnerships. Notable co-authors include:

  • Sylvan C. Baca
  • Ji-Heui Seo
  • Mark M. Pomerantz
  • Toni K. Choueiri
  • Jacob E. Berchuck

The scientist regularly publishes in various academic venues, with a particular concentration in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Clinical Oncology
  • Nature Communications
  • Cancer Research
  • Zenodo (CERN European Organization for Nuclear Research)

Selected recent papers demonstrate an emphasis on prostate cancer genomics, epigenetics, and diagnostic methods. These include:

  • Implementation of Germline Testing for Prostate Cancer: Philadelphia Prostate Cancer Consensus Conference 2019, 2020, Journal of Clinical Oncology
  • Detection of renal cell carcinoma using plasma and urine cell-free DNA methylomes, 2020, Nature Medicine
  • Prostate cancer reactivates developmental epigenomic programs during metastatic progression, 2020, Nature Genetics
  • EZH2 inhibition activates a dsRNA-STING-interferon stress axis that potentiates response to PD-1 checkpoint blockade in prostate cancer, 2021, Nature Cancer
  • Reprogramming of the FOXA1 cistrome in treatment-emergent neuroendocrine prostate cancer, 2021, Nature Communications

Best Publications

  • Strengthening the reporting of genetic association studies (STREGA): an extension of the STROBE statement

    Julian Little;Julian P.T. Higgins;John P.A. Ioannidis;John P.A. Ioannidis;David Moher

  • Assessing the impact of population stratification on genetic association studies.

    Matthew L Freedman;Matthew L Freedman;David Reich;David Reich;Kathryn L Penney;Kathryn L Penney;Gavin J McDonald;Gavin J McDonald

  • Fusion between transcription factor CBF beta/PEBP2 beta and a myosin heavy chain in acute myeloid leukemia.

    Pu Liu;Susan A. Tarlé;Amitav Hajra;David F. Claxton

  • A full genome search in multiple sclerosis

    G C Ebers;K Kukay;D E Bulman;A D Sadovnick

  • Multiple regions within 8q24 independently affect risk for prostate cancer.

    Christopher A Haiman;Nick Patterson;Matthew L Freedman;Matthew L Freedman;Simon R Myers

  • The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer.

    Mark M. Pomerantz;Nasim Ahmadiyeh;Nasim Ahmadiyeh;Li Jia;Paula Herman

  • Admixture mapping identifies 8q24 as a prostate cancer risk locus in African-American men

    Matthew L. Freedman;Christopher A. Haiman;Nick Patterson;Gavin J. McDonald;Gavin J. McDonald

  • PRISMS-4: Long-term efficacy of interferon-beta-1a in relapsing MS

    G Francis;R Hughes;J King;P Mitchell

  • A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer

    Ali Amin Al Olama;Zsofia Kote-Jarai;Sonja I. Berndt;David V. Conti

  • Demonstrating stratification in a European American population.

    Catarina D Campbell;Elizabeth L Ogburn;Kathryn L Lunetta;Helen N Lyon;Helen N Lyon

  • Principles for the post-GWAS functional characterization of cancer risk loci

    Matthew L Freedman;Alvaro N A Monteiro;Simon A Gayther;Simon A Gayther;Gerhard A Coetzee

  • 8q24 prostate, breast, and colon cancer risk loci show tissue-specific long-range interaction with MYC

    Nasim Ahmadiyeh;Mark M. Pomerantz;Chiara Grisanzio;Paula Herman

  • The androgen receptor cistrome is extensively reprogrammed in human prostate tumorigenesis

    Mark M Pomerantz;Fugen Li;David Y Takeda;David Y Takeda;Romina Lenci

  • Single Nucleotide Polymorphisms in Multiple Novel Thrombospondin Genes May Be Associated With Familial Premature Myocardial Infarction

    Eric J. Topol;Jeanette McCarthy;Stacey Gabriel;David J. Moliterno

  • Integrative eQTL-Based Analyses Reveal the Biology of Breast Cancer Risk Loci

    Qiyuan Li;Ji Heui Seo;Barbara Elaine Stranger;Aaron McKenna;Aaron McKenna

  • Final results of the Lung Screening Study, a randomized feasibility study of spiral CT versus chest X-ray screening for lung cancer

    John K. Gohagan;Pamela M. Marcus;Richard M. Fagerstrom;Paul F. Pinsky

  • Modeling and E-M estimation of haplotype-specific relative risks from genotype data for a case-control study of unrelated individuals.

    Daniel O. Stram;Celeste Leigh Pearce;Phillip Bretsky;Matthew Freedman

  • A Somatically Acquired Enhancer of the Androgen Receptor Is a Noncoding Driver in Advanced Prostate Cancer

    David Y. Takeda;David Y. Takeda;Sándor Spisák;Ji Heui Seo;Connor Bell

  • Functional Enhancers at the Gene-Poor 8q24 Cancer-Linked Locus

    Li Jia;Gilad Landan;Mark Pomerantz;Rami Jaschek

  • STrengthening the REporting of Genetic Association studies (STREGA)

    Julian Little;{Julian P. T} Higgins;{John P. A} Ioannidis;David Moher

Frequent Co-Authors

Christopher A. Haiman
Christopher A. Haiman University of Southern California
Toni K. Choueiri
Toni K. Choueiri Harvard University
Peter Kraft
Peter Kraft Harvard University
Kathryn L. Penney
Kathryn L. Penney Harvard University
Brian E. Henderson
Brian E. Henderson University of Southern California
David J. Hunter
David J. Hunter Harvard University
Alexander Gusev
Alexander Gusev Dana-Farber Cancer Institute
Daniel O. Stram
Daniel O. Stram University of Southern California
Paul D.P. Pharoah
Paul D.P. Pharoah University of Cambridge
Stephen J. Chanock
Stephen J. Chanock National Institutes of Health

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