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Sebastian Amigorena

Sebastian Amigorena

D-Index & Metrics

Immunology

D-Index
111
Citations
71483
World Ranking
462
National Ranking
13

Research.com Recognitions

  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Sebastian Amigorena is affiliated with the Institute Curie in France and has contributed extensively to the fields of immunology, molecular biology, and medicine. Their research primarily addresses immunology and microbiology, with a particular focus on immune cell function and interaction, immunotherapy and immune responses, and CAR-T cell therapy research. Additional research interests include T-cell and B-cell immunology, cancer immunotherapy and biomarkers, RNA modifications and cancer, as well as RNA and protein synthesis mechanisms.

Amigorena's scholarly output includes numerous publications in prominent scientific venues. Their frequent publication venues are:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Science Immunology
  • Cell Reports
  • Cancer Research

The scientist has collaborated frequently with several notable coauthors, including:

  • Christel Goudot (17 collaborations)
  • Olivier Lantz (15 collaborations)
  • Joshua J. Waterfall (14 collaborations)
  • Pierre-Emmanuel Bonté (13 collaborations)
  • Sandrine Heurtebise-Chrétien (9 collaborations)

Recent publications by Amigorena cover a range of topics related to cancer immunology and immune system regulation. Selected works include:

  • Lipid-Associated Macrophages Are Induced by Cancer-Associated Fibroblasts and Mediate Immune Suppression in Breast Cancer, 2022, Cancer Research
  • Tumor invasion in draining lymph nodes is associated with Treg accumulation in breast cancer patients, 2020, Nature Communications
  • The receptor DNGR-1 signals for phagosomal rupture to promote cross-presentation of dead-cell-associated antigens, 2020, Nature Immunology
  • Contribution of resident and circulating precursors to tumor-infiltrating CD8 + T cell populations in lung cancer, 2021, Science Immunology
  • Repeated peripheral infusions of anti-EGFRvIII CAR T cells in combination with pembrolizumab show no efficacy in glioblastoma: a phase 1 trial, 2024, Nature Cancer

Amigorena's body of work is recognized within the scientific community, including membership in the European Molecular Biology Organization (EMBO).

Best Publications

  • Isolation and Characterization of Exosomes from Cell Culture Supernatants and Biological Fluids

    Clotilde Théry;Sebastian Amigorena;Graça Raposo;Aled Clayton

  • Exosomes: composition, biogenesis and function

    Clotilde Théry;Laurence Zitvogel;Sebastian Amigorena

  • Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy.

    Lionel Apetoh;François Ghiringhelli;Antoine Tesniere;Antoine Tesniere;Antoine Tesniere;Michel Obeid;Michel Obeid;Michel Obeid

  • Rab27a and Rab27b control different steps of the exosome secretion pathway

    Matias Ostrowski;Nuno B. Carmo;Sophie Krumeich;Sophie Krumeich;Isabelle Fanget

  • Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell-derived exosomes

    Laurence Zitvogel;Armelle Regnault;Anne Lozier;Joseph Wolfers

  • Antigen Presentation and T Cell Stimulation by Dendritic Cells

    Pierre Guermonprez;Jenny Valladeau;Laurence Zitvogel;Clotilde Théry

  • Cross-presentation by dendritic cells.

    Olivier P. Joffre;Elodie Segura;Elodie Segura;Ariel Savina;Ariel Savina;Sebastian Amigorena;Sebastian Amigorena

  • Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming.

    Joseph Wolfers;Anne Lozier;Graça Raposo;Armelle Regnault

  • Proteomic Analysis of Dendritic Cell-Derived Exosomes: A Secreted Subcellular Compartment Distinct from Apoptotic Vesicles

    Clotilde Théry;Muriel Boussac;Philippe Véron;Paola Ricciardi-Castagnoli

  • Vaccination of metastatic melanoma patients with autologous dendritic cell (DC) derived-exosomes: results of thefirst phase I clinical trial

    Bernard Escudier;Thierry Dorval;Nathalie Chaput;Fabrice André

  • Molecular characterization of dendritic cell-derived exosomes. Selective accumulation of the heat shock protein hsc73.

    Clotilde Théry;Armelle Regnault;Jérôme Garin;Joseph Wolfers

  • Dissecting the Tumor Myeloid Compartment Reveals Rare Activating Antigen-Presenting Cells Critical for T Cell Immunity

    Miranda L. Broz;Mikhail Binnewies;Bijan Boldajipour;Amanda E. Nelson

  • Malignant effusions and immunogenic tumour-derived exosomes

    Fabrice Andre;Noel E C Schartz;Mojgan Movassagh;Caroline Flament

  • Fcγ Receptor–mediated Induction of Dendritic Cell Maturation and Major Histocompatibility Complex Class I–restricted Antigen Presentation after Immune Complex Internalization

    Armelle Regnault;Danielle Lankar;Valérie Lacabanne;Ana Rodriguez

  • Indirect activation of naïve CD4 + T cells by dendritic cell–derived exosomes

    Clotilde Théry;Livine Duban;Elodie Segura;Philippe Véron

  • Cold Tumors: A Therapeutic Challenge for Immunotherapy.

    Paola Bonaventura;Tala Shekarian;Vincent Alcazer;Jenny Valladeau-Guilemond

  • NOX2 Controls Phagosomal pH to Regulate Antigen Processing during Crosspresentation by Dendritic Cells

    Ariel Savina;Carolina Jancic;Stephanie Hugues;Pierre Guermonprez

  • ER–phagosome fusion defines an MHC class I cross-presentation compartment in dendritic cells

    Pierre Guermonprez;Loredana Saveanu;Monique Kleijmeer;Jean Davoust

  • Human Inflammatory Dendritic Cells Induce Th17 Cell Differentiation

    Elodie Segura;Maxime Touzot;Maxime Touzot;Armelle Bohineust;Armelle Bohineust;Antonio Cappuccio;Antonio Cappuccio

  • ICAM-1 on exosomes from mature dendritic cells is critical for efficient naive T-cell priming

    Elodie Segura;Carole Nicco;Carole Nicco;Bérangère Lombard;Bérangère Lombard;Philippe Véron;Philippe Véron

  • Selective transport of internalized antigens to the cytosol for MHC class I presentation in dendritic cells.

    Ana Rodriguez;Armelle Regnault;Monique Kleijmeer;Paola Ricciardi-Castagnoli

  • Phagocytosis and antigen presentation in dendritic cells.

    Ariel Savina;Sebastian Amigorena

Frequent Co-Authors

Clotilde Théry
Clotilde Théry PSL University
Graça Raposo
Graça Raposo Institut Curie
Wolf H. Fridman
Wolf H. Fridman Université Paris Cité
Laurence Zitvogel
Laurence Zitvogel University of Paris-Saclay
Fabrice Andre
Fabrice Andre Institut Gustave Roussy
Olivier Lantz
Olivier Lantz Institute Curie
Paola Ricciardi-Castagnoli
Paola Ricciardi-Castagnoli Toscana Life Sciences Foundation
Ira Mellman
Ira Mellman Parker Institute for Cancer Immunotherapy
Jean-Luc Teillaud
Jean-Luc Teillaud Grenoble Alpes University
Franck Perez
Franck Perez PSL University

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