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Immunology

D-Index
134
Citations
101570
World Ranking
196
National Ranking
127

Research.com Recognitions

  • 2011 - Member of the National Academy of Sciences
  • 2001 - Fellow of the American Academy of Arts and Sciences

Overview

Ira Mellman is affiliated with Genentech in the United States and has an extensive publication record in the fields of medicine, immunology, and microbiology. Their scientific contributions primarily focus on the intersection of cancer immunotherapy, immune cell function, and molecular biology.

The research topics covered by Ira Mellman include:

  • Cancer Immunotherapy and Biomarkers
  • Immune Cell Function and Interaction
  • CAR-T cell therapy research
  • Immunotherapy and Immune Responses
  • Immune cells in cancer
  • Cancer Genomics and Diagnostics
  • T-cell and B-cell Immunology

Their work spans several subfields such as immunology, oncology, molecular biology, cancer research, and surgery, with a significant number of publications under medicine and immunology as the main fields.

Notable recent publications by Ira Mellman include:

  • "Personalized RNA neoantigen vaccines stimulate T cells in pancreatic cancer," 2023, published in Nature
  • "Peripheral T cell expansion predicts tumour infiltration and clinical response," 2020, published in Nature
  • "The cancer-immunity cycle: Indication, genotype, and immunotype," 2023, published in Immunity
  • "IL-1 and IL-1ra are key regulators of the inflammatory response to RNA vaccines," 2022, published in Nature Immunology
  • "PD-L1 expression by dendritic cells is a key regulator of T-cell immunity in cancer," 2020, published in Nature Cancer

Frequent co-authors collaborating with Ira Mellman include:

  • Sanjeev Mariathasan
  • Thomas D. Wu
  • Lélia Delamarre
  • Zora Modrušan
  • Barzin Y. Nabet

Their research has appeared extensively in high-impact journals and venues, with primary publication outlets including:

  • Nature
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Regular and Young Investigator Award Abstracts
  • Cancer Research
  • Cancer Immunology Research

Ira Mellman has been recognized with membership in the National Academy of Sciences since 2011 and was named a Fellow of the American Academy of Arts and Sciences in 2001.

Best Publications

  • Oncology Meets Immunology: The Cancer-Immunity Cycle

    Daniel S. Chen;Daniel S. Chen;Ira Mellman;Ira Mellman

  • Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients

    Roy S. Herbst;Jean Charles Soria;Marcin Kowanetz;Gregg D. Fine

  • TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells.

    Sanjeev Mariathasan;Shannon J. Turley;Dorothee Nickles;Alessandra Castiglioni

  • Elements of cancer immunity and the cancer–immune set point

    Daniel S. Chen;Ira Mellman

  • Cancer immunotherapy comes of age

    Ira Mellman;George Coukos;Glenn Dranoff

  • Dendritic cells: specialized and regulated antigen processing machines.

    Ira S. Mellman;Ralph M. Steinman

  • ACIDIFICATION OF THE ENDOCYTIC AND EXOCYTIC PATHWAYS

    Ira Mellman;Renate Fuchs;Ari Helenius

  • Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide.

    Roberto Lande;Josh Gregorio;Valeria Facchinetti;Bithi Chatterjee;Bithi Chatterjee

  • The Biogenesis of Lysosomes

    Stuart Kornfeld;Ira Mellman

  • Endocytosis and molecular sorting

    Ira Mellman

  • Endocytosis and the recycling of plasma membrane.

    Ralph M. Steinman;Ira S. Mellman;William A Muller;Zanvil A. Cohn

  • T cell costimulatory receptor CD28 is a primary target for PD-1-mediated inhibition.

    Enfu Hui;Jeanne Cheung;Jing Zhu;Xiaolei Su

  • The Prioritization of Cancer Antigens: A National Cancer Institute Pilot Project for the Acceleration of Translational Research

    Martin A. Cheever;Martin A. Cheever;James P. Allison;Andrea S. Ferris;Olivera J. Finn

  • CELL BIOLOGY OF ANTIGEN PROCESSING IN VITRO AND IN VIVO

    E. Sergio Trombetta;Ira Mellman

  • The induction of tolerance by dendritic cells that have captured apoptotic cells.

    Ralph M. Steinman;Shannon Turley;Ira Mellman;Kayo Inaba

  • Predicting immunogenic tumour mutations by combining mass spectrometry and exome sequencing

    Mahesh Yadav;Suchit Jhunjhunwala;Qui T. Phung;Patrick Lupardus

  • Personalized RNA neoantigen vaccines stimulate T cells in pancreatic cancer

    Unknown

  • The mannose 6-phosphate receptor and the biogenesis of lysosomes

    Gareth Griffiths;Bernard Hoflack;Kai Simons;Ira Mellman

  • Developmental regulation of MHC class II transport in mouse dendritic cells

    Philippe Pierre;Shannon J. Turley;Evelina Gatti;Michael Hull

  • Differential Lysosomal Proteolysis in Antigen-Presenting Cells Determines Antigen Fate

    Lélia Delamarre;Margit Pack;Henry Chang;Ira Mellman

  • The small GTPase rab5 functions as a regulatory factor in the early endocytic pathway

    C. Bucci;R.G. Parton;I.H. Mather;H. Stunnenberg

  • THE BIOGENESIS OF L YSOSOMES

    Stuart Kornfeld;Ira Mellman

Frequent Co-Authors

Ralph M. Steinman
Ralph M. Steinman Rockefeller University
Ari Helenius
Ari Helenius ETH Zurich
Marc Pypaert
Marc Pypaert Yale University
Walter Hunziker
Walter Hunziker Agency for Science, Technology and Research
Sandra L. Schmid
Sandra L. Schmid The University of Texas Southwestern Medical Center
Leon E. Rosenberg
Leon E. Rosenberg Yale University
Kayo Inaba
Kayo Inaba Kyoto University
Richard A. Flavell
Richard A. Flavell Yale University
Paul Webster
Paul Webster House Clinic

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