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D-Index & Metrics

Biology and Biochemistry

D-Index
128
Citations
77755
World Ranking
439
National Ranking
281

Overview

Juan S. Bonifacino is affiliated with the National Institutes of Health in the United States. Their research focuses primarily on the fields of biochemistry, genetics, molecular biology, and medicine, with a significant emphasis on cell biology and molecular biology as subfields. Other areas of study include physiology, epidemiology, and neurology.

The main topics covered in their research include:

  • Cellular transport and secretion
  • Autophagy in Disease and Therapy
  • Lysosomal Storage Disorders Research
  • Endoplasmic Reticulum Stress and Disease
  • Retinal Development and Disorders
  • Lipid Membrane Structure and Behavior
  • Calcium signaling and nucleotide metabolism

Their recent publications feature a number of papers that illustrate ongoing work in cell biology and autophagy mechanisms:

  • Structure of Human ATG9A, the Only Transmembrane Protein of the Core Autophagy Machinery (2020, Cell Reports)
  • Distinct changes in endosomal composition promote NLRP3 inflammasome activation (2022, Nature Immunology)
  • α-Synuclein fibrils subvert lysosome structure and function for the propagation of protein misfolding between cells through tunneling nanotubes (2021, PLoS Biology)
  • The autophagy protein ATG9A enables lipid mobilization from lipid droplets (2021, Nature Communications)
  • Synaptic Vesicle Precursors and Lysosomes Are Transported by Different Mechanisms in the Axon of Mammalian Neurons (2020, Cell Reports)

Frequent coauthors in their work include:

  • Raffaella De Pace
  • Chad D. Williamson
  • Carlos M. Guardia
  • Michal Jarník
  • Tal Keren-Kaplan

Their studies have been published most frequently in the following venues:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Molecular Biology of the Cell
  • Cell Reports
  • Nature Communications
  • The Journal of Cell Biology

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

    Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif

  • Imaging intracellular fluorescent proteins at nanometer resolution.

    Eric Betzig;George H. Patterson;Rachid Sougrat;O. Wolf Lindwasser

  • Signals for Sorting of Transmembrane Proteins to Endosomes and Lysosomes

    Juan S Bonifacino;Linton M Traub

  • The Mechanisms of Vesicle Budding and Fusion

    Juan S Bonifacino;Benjamin S Glick

  • Rapid redistribution of Golgi proteins into the ER in cells treated with brefeldin A: evidence for membrane cycling from Golgi to ER.

    Jennifer Lippincott-Schwartz;Lydia C. Yuan;Juan S. Bonifacino;Richard D. Klausner

  • Interaction of tyrosine-based sorting signals with clathrin-associated proteins

    Hiroshi Ohno;Jay Stewart;Marie-Christine Fournier;Herbert Bosshart

  • Lysosomes as dynamic regulators of cell and organismal homeostasis

    Andrea Ballabio;Juan S. Bonifacino

  • Sorting of lysosomal proteins.

    Thomas Braulke;Juan S. Bonifacino

  • Ubiquitin and the control of protein fate in the secretory and endocytic pathways.

    Juan S. Bonifacino;Allan M. Weissman

  • Altered Trafficking of Lysosomal Proteins in Hermansky-Pudlak Syndrome Due to Mutations in the β3A Subunit of the AP-3 Adaptor

    Esteban C Dell’Angelica;Vorasuk Shotelersuk;Ruben C Aguilar;William A Gahl

  • Retrograde transport from endosomes to the trans-Golgi network.

    Juan S Bonifacino;Raul Rojas

  • Role of the mammalian retromer in sorting of the cation-independent mannose 6-phosphate receptor

    Cecilia N. Arighi;Lisa M. Hartnell;Ruben C. Aguilar;Carol R. Haft

  • Adaptor-related proteins.

    Margaret S Robinson;Juan S Bonifacino

  • A novel clathrin adaptor complex mediates basolateral targeting in polarized epithelial cells.

    Heike Fölsch;Hiroshi Ohno;Juan S Bonifacino;Ira Mellman

  • Lysosome-related organelles

    Esteban C. Dell'Angelica;Chris Mullins;Steve Caplan;Juan S. Bonifacino

  • Adaptins: the final recount.

    Markus Boehm;Juan S. Bonifacino

  • Degradation from the endoplasmic reticulum: disposing of newly synthesized proteins.

    Jennifer Lippincott-Schwartz;Juan S. Bonifacino;Lydia C. Yuan;Richard D. Klausner

  • The contribution of VHL substrate binding and HIF1-α to the phenotype of VHL loss in renal cell carcinoma

    Jodi K Maranchie;James R Vasselli;Joseph Riss;Juan S Bonifacino

  • Biosynthesis, cleavage, and degradation of the human immunodeficiency virus 1 envelope glycoprotein gp160.

    Ronald L. Willey;Juan S. Bonifacino;Barbara J. Potts;Malcolm A. Martin

  • Molecular bases for the recognition of tyrosine-based sorting signals.

    Juan S. Bonifacino;Esteban C. Dell'Angelica

Frequent Co-Authors

Esteban C. Dell'Angelica
Esteban C. Dell'Angelica University of California, Los Angeles
Allan M. Weissman
Allan M. Weissman National Institutes of Health
Rosa Puertollano
Rosa Puertollano National Institutes of Health
Jennifer Lippincott-Schwartz
Jennifer Lippincott-Schwartz Howard Hughes Medical Institute
Michael S. Marks
Michael S. Marks Children's Hospital of Philadelphia
William A. Gahl
William A. Gahl National Institutes of Health
Lawrence E. Samelson
Lawrence E. Samelson National Institutes of Health
Takashi Saito
Takashi Saito Nagoya City University

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