World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
100
Citations
38667
World Ranking
1507
National Ranking
851

Research.com Recognitions

  • 2012 - Fellow of the American Association for the Advancement of Science (AAAS)
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

Lawrence E. Samelson is affiliated with the National Institutes of Health in the United States. Their research primarily focuses on immunology and microbiology, with significant contributions to medicine. The scientist's work spans multiple subfields, including immunology, oncology, molecular biology, cell biology, and electrical and electronic engineering.

The main topics covered in their research include:

  • T-cell and B-cell Immunology
  • CAR-T cell therapy research
  • Immune Cell Function and Interaction
  • Ubiquitin and proteasome pathways
  • Monoclonal and Polyclonal Antibodies Research
  • Polyamine Metabolism and Applications
  • Microtubule and mitosis dynamics

Recent publications by Lawrence E. Samelson demonstrate an emphasis on immune cell signaling and molecular mechanisms within T cells. These include:

  • "Bypassing ubiquitination enables LAT recycling to the cell surface and enhanced signaling in T cells," 2020, PLoS ONE
  • "Microclusters as T Cell Signaling Hubs: Structure, Kinetics, and Regulation," 2021, Frontiers in Cell and Developmental Biology
  • "In vitro reconstitution reveals cooperative mechanisms of adapter protein-mediated activation of phospholipase C-γ1 in T cells," 2022, Journal of Biological Chemistry
  • "Inherited ARPC5 mutations cause an actinopathy impairing cell motility and disrupting cytokine signaling," 2023, Nature Communications
  • "Expression of a TMC6-TMC8-CIB1 heterotrimeric complex in lymphocytes is regulated by each of the components," 2020, Journal of Biological Chemistry

Frequent co-authors collaborating with Lawrence E. Samelson include Lakshmi Balagopalan, Katherine M. McIntire, Junya Wada, Jason Yi, and Neriah Alvinez. These collaborations have contributed to the breadth and depth of their research output.

The scientist has published extensively in several venues, with repeated contributions to the Journal of Biological Chemistry, bioRxiv (Cold Spring Harbor Laboratory), The Journal of Immunology, PLoS ONE, and Frontiers in Cell and Developmental Biology.

Recognition for their work includes being named a Fellow of the American Association for the Advancement of Science (AAAS) in 2012 and membership in the Association of American Physicians.

Best Publications

  • Identification of a monoclonal antibody specific for a murine T3 polypeptide

    Oberdan Leo;Michele Foo;David H. Sachs;Lawrence E. Samelson

  • LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation.

    Weiguo Zhang;Joanne Sloan-Lancaster;Jason Kitchen;Ronald P Trible

  • LAT Palmitoylation: Its Essential Role in Membrane Microdomain Targeting and Tyrosine Phosphorylation during T Cell Activation

    Weiguo Zhang;Ronald P Trible;Lawrence E Samelson

  • Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lck

    André Veillette;Michael A. Bookman;Eva M. Horak;Lawrence E. Samelson

  • Molecular Basis of T Cell Inactivation by CTLA-4

    Kyung Mi Lee;Ellen Chuang;Matthew Griffin;Roli Khattri

  • Association of the fyn protein-tyrosine kinase with the T-cell antigen receptor.

    Lawrence E. Samelson;Andrew F. Phillips;Elise T. Luong;Richard D. Klausner

  • Signal Transduction Mediated by the T Cell Antigen Receptor: The Role of Adapter Proteins*

    Lawrence E. Samelson

  • Complex Complexes: Signaling at the TCR

    Ronald L Wange;Lawrence E Samelson

  • T cell receptor ligation induces the formation of dynamically regulated signaling assemblies

    Stephen C. Bunnell;David I. Hong;Julia R. Kardon;Tetsuo Yamazaki

  • Essential Role of LAT in T Cell Development

    Weiguo Zhang;Connie L Sommers;Deborah N Burshtyn;Christopher C Stebbins

  • LAT Is Required for TCR-Mediated Activation of PLCγ1 and the Ras Pathway

    Timothy S Finco;Theresa Kadlecek;Weiguo Zhang;Lawrence E Samelson

  • In vitro cell-mediated immune responses to the male specific(H-Y) antigen in mice.

    R D Gordon;E Simpson;L E Samelson

  • Zeta phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists

    Joaquín Madrenas;Ronald L. Wange;Jennifer L. Wang;Noah Isakov

  • Dynamic Actin Polymerization Drives T Cell Receptor–Induced Spreading: A Role for the Signal Transduction Adaptor LAT

    Stephen C. Bunnell;Veena Kapoor;Ronald P. Trible;Weiguo Zhang

  • T cell antigen receptor activation pathways: the tyrosine kinase connection.

    Richard D. Klausner;Lawrence E. Samelson

  • Increases in tyrosine phosphorylation are detectable before phospholipase C activation after T cell receptor stimulation.

    Carl H. June;Mary C. Fletcher;Jeffrey A. Ledbetter;Lawrence E. Samelson

  • Association of Grb2, Gads, and Phospholipase C-γ1 with Phosphorylated LAT Tyrosine Residues EFFECT OF LAT TYROSINE MUTATIONS ON T CELL ANTIGEN RECEPTOR-MEDIATED SIGNALING

    Weiguo Zhang;Weiguo Zhang;Ronald P. Trible;Minghua Zhu;Stanley K. Liu

  • Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation

    Valentino Parravicini;Valentino Parravicini;Massimo Gadina;Martina Kovarova;Martina Kovarova;Sandra Odom

  • Antigen activation of murine T cells induces tyrosine phosphorylation of a polypeptide associated with the T cell antigen receptor

    Lawrence E. Samelson;Maitray D. Patel;Allan M. Weissman;Joe B. Harford

  • Inhibition of tyrosine phosphorylation prevents T-cell receptor-mediated signal transduction.

    Carl H. June;Mary C. Fletcher;Jeffrey A. Ledbetter;Gary L. Schieven

Frequent Co-Authors

Weiguo Zhang
Weiguo Zhang Duke University
Paul E. Love
Paul E. Love National Institutes of Health
Carl H. June
Carl H. June University of Pennsylvania
Ronald H. Schwartz
Ronald H. Schwartz National Institutes of Health
John J. O'Shea
John J. O'Shea National Institutes of Health
Allan M. Weissman
Allan M. Weissman National Institutes of Health
Ettore Appella
Ettore Appella National Institutes of Health
Peter Schuck
Peter Schuck National Institutes of Health
Juan S. Bonifacino
Juan S. Bonifacino National Institutes of Health

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