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Biology and Biochemistry

D-Index
70
Citations
19663
World Ranking
6942
National Ranking
3199

Overview

Paul E. Love is affiliated with the National Institutes of Health in the United States and has contributed extensively to research in immunology, molecular biology, and medicine. Their work spans a range of topics primarily centered on immune cell functions and interactions, with a strong focus on T-cell and B-cell immunology and CAR-T cell therapy research.

Their research interests include:

  • Immune Cell Function and Interaction
  • T-cell and B-cell Immunology
  • CAR-T cell therapy research
  • Immunotherapy and Immune Responses
  • Epigenetics and DNA Methylation
  • Cytokine Signaling Pathways and Interactions
  • Ubiquitin and proteasome pathways

Paul E. Love has published numerous papers in well-regarded journals, with recent notable works including:

  • New insights into TCR β-selection, 2021, Trends in Immunology
  • CD5 dynamically calibrates basal NF-κB signaling in T cells during thymic development and peripheral activation, 2020, Proceedings of the National Academy of Sciences
  • New Insights into Epigenetic Regulation of T Cell Differentiation, 2021, Cells
  • HIRA, a DiGeorge Syndrome Candidate Gene, Confers Proper Chromatin Accessibility on HSCs and Supports All Stages of Hematopoiesis, 2020, Cell Reports
  • CD5 signalosome coordinates antagonist TCR signals to control the generation of Treg cells induced by foreign antigens, 2020, Proceedings of the National Academy of Sciences

Their frequent co-authors are Guillaume Gaud, Seeyoung Choi, Bin Zhao, Taisuke Kondo, and Paul François, indicating active collaborative efforts in their research endeavors.

Paul E. Love's research has been published multiple times in prominent scientific venues, including:

  • Frontiers in Immunology
  • Nature Immunology
  • Proceedings of the National Academy of Sciences
  • Nature Communications
  • Science Signaling

Their scientific domain is multidisciplinary, spanning areas such as immunology, microbiology, biochemistry, genetics, molecular biology, and medicine. The primary subfields cover immunology, molecular biology, oncology, cancer research, and genetics.

Best Publications

  • Antiphospholipid Antibodies: Anticardiolipin and the Lupus Anticoagulant in Systemic Lupus Erythematosus (SLE) and in Non-SLE Disorders: Prevalence and Clinical Significance

    Paul E. Love;Samuel A. Santoro

  • Defective lymphoid development in mice lacking expression of the common cytokine receptor gamma chain.

    Xiqing Cao;Elizabeth W. Shores;Jane Hu-Li;Miriam R. Anver

  • CD5 Expression Is Developmentally Regulated By T Cell Receptor (TCR) Signals and TCR Avidity

    Hala S. Azzam;Alex Grinberg;Kin Lui;Howard Shen

  • Essential Role of LAT in T Cell Development

    Weiguo Zhang;Connie L Sommers;Deborah N Burshtyn;Christopher C Stebbins

  • Regulatory mechanisms in T cell receptor signalling

    Guillaume Gaud;Renaud Lesourne;Paul E. Love

  • Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice.

    Timothy LaVaute;Sophia Smith;Sharon Cooperman;Kazuhiro Iwai

  • Mice Deficient in Nuclear Factor (NF)-κB/p52 Present with Defects in Humoral Responses, Germinal Center Reactions, and Splenic Microarchitecture

    Guido Franzoso;Louise Carlson;Ljiljana Poljak;Elizabeth W. Shores

  • LAT Is Essential for FcεRI-Mediated Mast Cell Activation

    Shinichiroh Saitoh;Ramachandran Arudchandran;T.Scott Manetz;Weiguo Zhang

  • Failure to Produce Mitochondrial DNA Results in Embryonic Lethality in Rnaseh1 Null Mice

    Susana M. Cerritelli;Ella G. Frolova;Chiguang Feng;Alexander Grinberg

  • Genetic ablations of iron regulatory proteins 1 and 2 reveal why iron regulatory protein 2 dominates iron homeostasis

    Esther G Meyron‐Holtz;Manik C Ghosh;Kazuhiro Iwai;Timothy LaVaute

  • A role for CCR9 in T lymphocyte development and migration.

    Shoji Uehara;Alexander Grinberg;Joshua M. Farber;Paul E. Love

  • Altered striatal function in a mutant mouse lacking D1A dopamine receptors.

    J Drago;C R Gerfen;J E Lachowicz;H Steiner

  • A LAT mutation that inhibits T cell development yet induces lymphoproliferation.

    Connie L. Sommers;Cheung-Seog Park;Jan Lee;Chiguang Feng

  • TCR Signal Strength Influences αβ/γδ Lineage Fate

    Sandra M. Hayes;LiQi Li;Paul E. Love

  • Fine tuning of TCR signaling by CD5.

    Hala S. Azzam;Jan B. DeJarnette;Kun Huang;Rebecca Emmons

  • LEF-1 and TCF-1 orchestrate T(FH) differentiation by regulating differentiation circuits upstream of the transcriptional repressor Bcl6.

    Youn Soo Choi;Jodi A. Gullicksrud;Shaojun Xing;Zhouhao Zeng

  • CCR6 is required for IL-23–induced psoriasis-like inflammation in mice

    Michael N. Hedrick;Anke S. Lonsdorf;Anke S. Lonsdorf;Aiko Konno Shirakawa;Aiko Konno Shirakawa;Chyi Chia Richard Lee

  • T cell development in mice that lack the zeta chain of the T cell antigen receptor complex

    Paul E. Love;Elizabeth W. Shores;Mark D. Johnson;Michel L. Tremblay

  • ITAM-mediated Signaling by the T-Cell Antigen Receptor

    Paul E. Love;Sandra M. Hayes

  • Selective Thymus Settling Regulated by Cytokine and Chemokine Receptors

    Benjamin A. Schwarz;Arivazhagan Sambandam;Ivan Maillard;Benjamin C. Harman

Frequent Co-Authors

Alexander Grinberg
Alexander Grinberg National Institutes of Health
Lawrence E. Samelson
Lawrence E. Samelson National Institutes of Health
Alfred Singer
Alfred Singer National Institutes of Health
Heiner Westphal
Heiner Westphal National Institutes of Health
Joshua M. Farber
Joshua M. Farber National Institutes of Health
Kairong Cui
Kairong Cui National Institutes of Health
Daniel W. McVicar
Daniel W. McVicar National Institutes of Health
Weiguo Zhang
Weiguo Zhang Duke University
Keji Zhao
Keji Zhao National Institutes of Health
Xi Chen
Xi Chen University of California, Davis

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