D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 44 Citations 8,177 152 World Ranking 16193 National Ranking 356

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Immune system
  • Amino acid

Balbino Alarcón spends much of his time researching T-cell receptor, Cell biology, T cell, Signal transduction and CD3. His work carried out in the field of T-cell receptor brings together such families of science as Molecular biology, Biochemistry and Major histocompatibility complex, Antigen. The various areas that Balbino Alarcón examines in his Cell biology study include Immunological synapse, Internalization and Antigen-presenting cell.

Specifically, his work in T cell is concerned with the study of Jurkat cells. His biological study spans a wide range of topics, including Thymocyte, Transgene and Phosphorylation. His CD3 research includes themes of Cytoplasm, Biophysics, Conformational change, Protein subunit and Protein structure.

His most cited work include:

  • The T Cell Receptor/CD3 Complex: A Dynamic Protein Ensemble (647 citations)
  • Recruitment of Nck by CD3ϵ Reveals a Ligand-Induced Conformational Change Essential for T Cell Receptor Signaling and Synapse Formation (371 citations)
  • Coexistence of multivalent and monovalent TCRs explains high sensitivity and wide range of response. (261 citations)

What are the main themes of his work throughout his whole career to date?

Balbino Alarcón mainly investigates T-cell receptor, Cell biology, T cell, Molecular biology and Receptor. His T-cell receptor research incorporates elements of Jurkat cells, Major histocompatibility complex, Antigen, Signal transduction and CD3. His Cell biology research is multidisciplinary, incorporating perspectives in Antigen-presenting cell, Immunological synapse, Conformational change, Biochemistry and Internalization.

The T cell study combines topics in areas such as Cytotoxic T cell, Transgene and Tyrosine phosphorylation. His Molecular biology research integrates issues from Phenotype, CD8 and Virology. The Receptor study which covers Cell that intersects with Extracellular.

He most often published in these fields:

  • T-cell receptor (53.95%)
  • Cell biology (53.29%)
  • T cell (32.24%)

What were the highlights of his more recent work (between 2016-2021)?

  • Cell biology (53.29%)
  • Antigen (19.74%)
  • T cell (32.24%)

In recent papers he was focusing on the following fields of study:

Balbino Alarcón mostly deals with Cell biology, Antigen, T cell, T-cell receptor and Antibody. In his research, Balbino Alarcón undertakes multidisciplinary study on Cell biology and Vimentin. The study incorporates disciplines such as Cell, Cytotoxic T cell, B-cell receptor and Germinal center in addition to Antigen.

His T cell study integrates concerns from other disciplines, such as Proinflammatory cytokine and Cellular differentiation. His research in T-cell receptor intersects with topics in Transcription, Biophysics, Ceramide and Major histocompatibility complex. His Major histocompatibility complex research includes elements of CD3 Complex, Endosome, Signal transduction, Endocytosis and Binding site.

Between 2016 and 2021, his most popular works were:

  • Cell Biology of T Cell Receptor Expression and Regulation (72 citations)
  • The Allostery Model of TCR Regulation (24 citations)
  • The TCR is an allosterically regulated macromolecular machinery changing its conformation while working. (19 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Immune system
  • Amino acid

His primary areas of investigation include T-cell receptor, Cell biology, Antigen, Biophysics and T cell. His studies deal with areas such as Major histocompatibility complex and Endosome as well as T-cell receptor. His Cell biology study incorporates themes from Immunoglobulin class switching, Antibody, Germinal center and Vaccination.

Balbino Alarcón interconnects B cell, IL-2 receptor, CD40 and Antigen-presenting cell in the investigation of issues within Antigen. As part of the same scientific family, Balbino Alarcón usually focuses on Biophysics, concentrating on Phosphorylation and intersecting with CD3, Multiprotein complex, Ligand, Receptor and Cell surface receptor. His research in T cell intersects with topics in Membrane cholesterol, Biochemistry, Signal transduction and Endocytosis.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

The T Cell Receptor/CD3 Complex: A Dynamic Protein Ensemble

Hans Clevers;Balbino Alarcon;Thomas Wileman;Cox Terhorst.
Annual Review of Immunology (1988)

1043 Citations

Recruitment of Nck by CD3ϵ Reveals a Ligand-Induced Conformational Change Essential for T Cell Receptor Signaling and Synapse Formation

Diana Gil;Wolfgang W.A. Schamel;Marı́a Montoya;Francisco Sánchez-Madrid.
Cell (2002)

521 Citations

Coexistence of multivalent and monovalent TCRs explains high sensitivity and wide range of response.

Wolfgang W.A. Schamel;Ignacio Arechaga;Ruth M. Risueño;Hisse M. van Santen.
Journal of Experimental Medicine (2005)

340 Citations

CD3δ deficiency arrests development of the αβ but not the γδ T cell lineage

Vibhuti P. Dave;Zhensheng Cao;Carol Browne;Balbino Alarcon.
The EMBO Journal (1997)

271 Citations

Full activation of the T cell receptor requires both clustering and conformational changes at CD3.

Susana Minguet;Mahima Swamy;Balbino Alarcón;Immanuel F. Luescher.
Immunity (2007)

271 Citations

Polysaccharides as antiviral agents: antiviral activity of carrageenan.

M. E González;Balbino Alarcón;Luís Carrasco.
Antimicrobial Agents and Chemotherapy (1987)

224 Citations

MTOC translocation modulates IS formation and controls sustained T cell signaling.

Noa B. Martín-Cófreces;Javier Robles-Valero;J. Román Cabrero;María Mittelbrunn;María Mittelbrunn.
Journal of Cell Biology (2008)

201 Citations

Multivalent structure of an αβT cell receptor

Gemma Fernández-Miguel;Balbino Alarcón;Antonio Iglesias;Horst Bluethmann.
Proceedings of the National Academy of Sciences of the United States of America (1999)

196 Citations

Internalization and intracellular fate of TCR-CD3 complexes.

Andres Alcover;Balbino Alarcon.
Critical Reviews in Immunology (2000)

183 Citations

Increased Sensitivity of Antigen-Experienced T Cells through the Enrichment of Oligomeric T Cell Receptor Complexes

Rashmi Kumar;María Ferez;Mahima Swamy;Ignacio Arechaga.
Immunity (2011)

175 Citations

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