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Biology and Biochemistry

D-Index
59
Citations
11076
World Ranking
12683
National Ranking
256

Overview

Balbino Alarcón is affiliated with the Spanish National Research Council in Spain. Their research spans various fields, prominently centered on Medicine, Immunology and Microbiology, and Biochemistry, Genetics and Molecular Biology. The subfields they focus on include Immunology, Molecular Biology, Oncology, Infectious Diseases, and Genetics.

The core topics of Balbino Alarcón's work encompass T-cell and B-cell Immunology, Immune Cell Function and Interaction, CAR-T cell therapy research, SARS-CoV-2 and COVID-19 Research, Chronic Lymphocytic Leukemia Research, Cancer-related Molecular Pathways, and Immunotherapy and Immune Responses.

Balbino Alarcón has authored multiple papers in prominent scientific journals. Notable recent publications include:

  • "SFRP1 modulates astrocyte-to-microglia crosstalk in acute and chronic neuroinflammation" (2021, EMBO Reports)
  • "Longitudinal dynamics of SARS-CoV-2-specific cellular and humoral immunity after natural infection or BNT162b2 vaccination" (2021, PLoS Pathogens)
  • "Overexpression of wild type RRAS2, without oncogenic mutations, drives chronic lymphocytic leukemia" (2022, Molecular Cancer)
  • "Flow cytometry multiplexed method for the detection of neutralizing human antibodies to the native SARS-CoV-2 spike protein" (2021, EMBO Molecular Medicine)
  • "A hotspot mutation targeting the R-RAS2 GTPase acts as a potent oncogenic driver in a wide spectrum of tumors" (2022, Cell Reports)

Frequent coauthors who have collaborated with Balbino Alarcón include Xosé R. Bustelo, Aldo Borroto, Pilar Delgado, Alejandro M. Hortal, and Clara L. Oeste. This network reflects consistent collaboration within their research community.

Publications by Balbino Alarcón frequently appear in several journals, with the following venues publishing the highest numbers of their works:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Frontiers in Immunology
  • The Journal of Immunology
  • Molecular Cancer
  • Cell Reports

Best Publications

  • The T Cell Receptor/CD3 Complex: A Dynamic Protein Ensemble

    Hans Clevers;Balbino Alarcon;Thomas Wileman;Cox Terhorst

  • Recruitment of Nck by CD3ϵ Reveals a Ligand-Induced Conformational Change Essential for T Cell Receptor Signaling and Synapse Formation

    Diana Gil;Wolfgang W.A. Schamel;Marı́a Montoya;Francisco Sánchez-Madrid

  • Coexistence of multivalent and monovalent TCRs explains high sensitivity and wide range of response.

    Wolfgang W.A. Schamel;Ignacio Arechaga;Ruth M. Risueño;Hisse M. van Santen

  • Full activation of the T cell receptor requires both clustering and conformational changes at CD3.

    Susana Minguet;Mahima Swamy;Balbino Alarcón;Immanuel F. Luescher

  • CD3δ deficiency arrests development of the αβ but not the γδ T cell lineage

    Vibhuti P. Dave;Zhensheng Cao;Carol Browne;Balbino Alarcon

  • Cell Biology of T Cell Receptor Expression and Regulation

    Andrés Alcover;Balbino Alarcón;Vincenzo Di Bartolo

  • Polysaccharides as antiviral agents: antiviral activity of carrageenan.

    M. E González;Balbino Alarcón;Luís Carrasco

  • MTOC translocation modulates IS formation and controls sustained T cell signaling.

    Noa B. Martín-Cófreces;Javier Robles-Valero;J. Román Cabrero;María Mittelbrunn;María Mittelbrunn

  • A Cholesterol-Based Allostery Model of T Cell Receptor Phosphorylation

    Mahima Swamy;Mahima Swamy;Mahima Swamy;Katharina Beck-Garcia;Katharina Beck-Garcia;Esmeralda Beck-Garcia;Esmeralda Beck-Garcia;Frederike A. Hartl

  • Internalization and intracellular fate of TCR-CD3 complexes.

    Andres Alcover;Balbino Alarcon

  • Multivalent structure of an αβT cell receptor

    Gemma Fernández-Miguel;Balbino Alarcón;Antonio Iglesias;Horst Bluethmann

  • T cell receptor internalization from the immunological synapse is mediated by TC21 and RhoG GTPase-dependent phagocytosis.

    Nuria Martínez-Martín;Elena Fernández-Arenas;Saso Cemerski;Pilar Delgado

  • Increased Sensitivity of Antigen-Experienced T Cells through the Enrichment of Oligomeric T Cell Receptor Complexes

    Rashmi Kumar;María Ferez;Mahima Swamy;Ignacio Arechaga

  • Initiation of TCR signaling: regulation within CD3 dimers.

    Balbino Alarcón;Diana Gil;Pilar Delgado;Wolfgang W. A. Schamel

  • CD3δ couples T-cell receptor signalling to ERK activation and thymocyte positive selection

    Pilar Delgado;Edgar Fernández;Vibhuti Dave;Dietmar Kappes

  • Triggering the TCR Complex Causes the Downregulation of Nonengaged Receptors by a Signal Transduction-Dependent Mechanism

    Ester San José;Aldo Borroto;Florence Niedergang;Andrés Alcover

  • T cell receptor engagement by peptide–MHC ligands induces a conformational change in the CD3 complex of thymocytes

    Diana Gil;Adam G. Schrum;Balbino Alarcón;Ed Palmer

  • The immunological synapse: a cause or consequence of T‐cell receptor triggering?

    Balbino Alarcón;David Mestre;Nuria Martínez-Martín

  • Assembly of the TCR/CD3 complex: CD3 epsilon/delta and CD3 epsilon/gamma dimers associate indistinctly with both TCR alpha and TCR beta chains. Evidence for a double TCR heterodimer model.

    Ester San José;Almudena G. Sahuquillo;Rafael Bragado;Balbino Alarcón

  • The CD3-gamma and CD3-delta subunits of the T cell antigen receptor can be expressed within distinct functional TCR/CD3 complexes.

    B. Alarcon;S. C. Ley;F. Sanchez-Madrid;R. S. Blumberg

Frequent Co-Authors

Wolfgang W. A. Schamel
Wolfgang W. A. Schamel University of Freiburg
Francisco Sánchez-Madrid
Francisco Sánchez-Madrid Autonomous University of Madrid
Luis Carrasco
Luis Carrasco Centro de Biología Molecular Severo Ochoa
Manuel Fresno
Manuel Fresno Autonomous University of Madrid
Xosé R. Bustelo
Xosé R. Bustelo University of Salamanca
Andrés Alcover
Andrés Alcover Institut Pasteur
Thomas Höfer
Thomas Höfer German Cancer Research Center
Paola Bovolenta
Paola Bovolenta Spanish National Research Council
Josefina Casas
Josefina Casas Spanish National Research Council
Eugenio Santos
Eugenio Santos University of Salamanca

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